ENSG00000094631

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334136 ENSG00000094631 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC6 protein_coding protein_coding 32.29502 40.72387 25.06628 2.703007 1.0873 -0.6999055 7.5274360 12.0849040 5.0247202 1.9666334 0.5454522 -1.2644158 0.22690417 0.29270000 0.202533333 -0.09016667 0.2703226529 5.651886e-05 FALSE TRUE
ENST00000430858 ENSG00000094631 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC6 protein_coding protein_coding 32.29502 40.72387 25.06628 2.703007 1.0873 -0.6999055 0.8994679 2.4554066 0.1429582 0.4812638 0.1429582 -4.0106162 0.02308750 0.05920000 0.006066667 -0.05313333 0.0431045485 5.651886e-05   FALSE
ENST00000465457 ENSG00000094631 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC6 protein_coding retained_intron 32.29502 40.72387 25.06628 2.703007 1.0873 -0.6999055 1.9411056 1.3452248 2.1100491 0.2795366 0.6374111 0.6455655 0.06180417 0.03413333 0.083233333 0.04910000 0.2656652325 5.651886e-05 FALSE FALSE
ENST00000480525 ENSG00000094631 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC6 protein_coding nonsense_mediated_decay 32.29502 40.72387 25.06628 2.703007 1.0873 -0.6999055 0.5078770 0.1833849 1.5604678 0.1833849 1.5604678 3.0216474 0.01672500 0.00430000 0.057400000 0.05310000 0.9803477381 5.651886e-05 FALSE FALSE
ENST00000488543 ENSG00000094631 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC6 protein_coding retained_intron 32.29502 40.72387 25.06628 2.703007 1.0873 -0.6999055 1.8516167 0.9721665 1.9652109 0.2421246 0.2136588 1.0079671 0.05820000 0.02436667 0.078033333 0.05366667 0.0053468140 5.651886e-05 FALSE TRUE
ENST00000488905 ENSG00000094631 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC6 protein_coding retained_intron 32.29502 40.72387 25.06628 2.703007 1.0873 -0.6999055 1.7664458 0.7193174 1.7862031 0.2603478 0.1675552 1.3003318 0.05582083 0.01756667 0.070966667 0.05340000 0.0005735327 5.651886e-05 FALSE FALSE
ENST00000645643 ENSG00000094631 HEK293_OSMI2_2hA HEK293_TMG_2hB HDAC6 protein_coding nonsense_mediated_decay 32.29502 40.72387 25.06628 2.703007 1.0873 -0.6999055 4.5183604 10.9681547 1.2990591 1.4503099 0.4444647 -3.0680334 0.12240417 0.27486667 0.052600000 -0.22226667 0.0008924094 5.651886e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000094631 E001 0.7331471 0.0172671820 1.937578e-01 3.185058e-01 X 48801377 48801395 19 + 0.000 0.271 10.098
ENSG00000094631 E002 3.0132082 0.0050760140 7.630749e-02 1.535919e-01 X 48801396 48801431 36 + 0.733 0.470 -1.177
ENSG00000094631 E003 2.5337821 0.0246563395 9.228305e-01 9.553310e-01 X 48801432 48801699 268 + 0.471 0.502 0.154
ENSG00000094631 E004 1.3201661 0.0562592875 9.436540e-01 9.686517e-01 X 48801700 48801751 52 + 0.296 0.321 0.163
ENSG00000094631 E005 0.1472490 0.0425979866 2.052964e-01   X 48801752 48801792 41 + 0.173 0.000 -13.300
ENSG00000094631 E006 1.8027258 0.0076801907 9.121784e-02 1.770335e-01 X 48801793 48801873 81 + 0.595 0.319 -1.441
ENSG00000094631 E007 7.1940229 0.0615144545 7.600837e-02 1.531281e-01 X 48801874 48801944 71 + 1.032 0.770 -1.001
ENSG00000094631 E008 0.4460135 0.0260354423 1.412184e-02 3.850408e-02 X 48801949 48801990 42 + 0.392 0.000 -15.007
ENSG00000094631 E009 1.7423479 0.0078836808 3.725347e-03 1.237040e-02 X 48801991 48802015 25 + 0.692 0.217 -2.593
ENSG00000094631 E010 2.0723455 0.0068543444 1.933657e-02 5.006225e-02 X 48802016 48802022 7 + 0.692 0.318 -1.856
ENSG00000094631 E011 0.0000000       X 48802023 48802033 11 +      
ENSG00000094631 E012 2.7206847 0.0056196906 8.956317e-01 9.373457e-01 X 48802034 48802054 21 + 0.538 0.529 -0.040
ENSG00000094631 E013 3.5676697 0.0044983465 9.089845e-01 9.461806e-01 X 48802055 48802063 9 + 0.595 0.628 0.144
ENSG00000094631 E014 4.0857013 0.0040620396 6.118317e-01 7.308856e-01 X 48802064 48802066 3 + 0.595 0.690 0.407
ENSG00000094631 E015 7.1481135 0.0023562227 6.173040e-01 7.351374e-01 X 48802067 48802081 15 + 0.895 0.849 -0.178
ENSG00000094631 E016 7.1481135 0.0023562227 6.173040e-01 7.351374e-01 X 48802082 48802083 2 + 0.895 0.849 -0.178
ENSG00000094631 E017 19.2634427 0.0013189833 8.868587e-01 9.316561e-01 X 48802084 48802109 26 + 1.247 1.252 0.021
ENSG00000094631 E018 27.6566208 0.0007269178 7.171204e-01 8.125911e-01 X 48802110 48802132 23 + 1.406 1.398 -0.027
ENSG00000094631 E019 28.5141146 0.0006927574 8.196249e-01 8.861036e-01 X 48802133 48802142 10 + 1.414 1.417 0.008
ENSG00000094631 E020 2.9818577 0.0830859751 9.858407e-01 9.951701e-01 X 48802143 48802158 16 + 0.537 0.559 0.102
ENSG00000094631 E021 3.4237185 0.0806774953 4.261245e-01 5.689800e-01 X 48802159 48802167 9 + 0.691 0.559 -0.576
ENSG00000094631 E022 3.0571006 0.0253647544 4.355132e-01 5.777495e-01 X 48802168 48802170 3 + 0.646 0.529 -0.523
ENSG00000094631 E023 3.1011235 0.0050038407 1.215046e-02 3.389138e-02 X 48802171 48802185 15 + 0.805 0.436 -1.637
ENSG00000094631 E024 2.9559508 0.0052360875 2.485204e-02 6.156768e-02 X 48802186 48802186 1 + 0.771 0.436 -1.500
ENSG00000094631 E025 5.4970220 0.0030125169 1.479900e-02 4.004264e-02 X 48802187 48802206 20 + 0.970 0.670 -1.179
ENSG00000094631 E026 11.5284448 0.0014702871 2.179144e-02 5.524095e-02 X 48802207 48802235 29 + 1.195 0.985 -0.763
ENSG00000094631 E027 7.7058169 0.0036075969 2.161281e-02 5.487264e-02 X 48802236 48802272 37 + 1.071 0.821 -0.939
ENSG00000094631 E028 4.1257499 0.0040677891 5.024612e-04 2.169122e-03 X 48802273 48802514 242 + 0.946 0.470 -2.006
ENSG00000094631 E029 3.3904378 0.0046823286 5.890254e-04 2.493556e-03 X 48802515 48802549 35 + 0.895 0.401 -2.177
ENSG00000094631 E030 2.0776440 0.0161671208 4.492397e-03 1.452117e-02 X 48802550 48802551 2 + 0.733 0.271 -2.348
ENSG00000094631 E031 1.8726556 0.0075935888 2.785748e-01 4.182464e-01 X 48802552 48802662 111 + 0.537 0.362 -0.914
ENSG00000094631 E032 106.5175646 0.0003642259 3.194814e-04 1.458850e-03 X 48802663 48802779 117 + 2.055 1.941 -0.382
ENSG00000094631 E033 60.7888939 0.0036317464 1.881703e-02 4.893250e-02 X 48802780 48802785 6 + 1.814 1.703 -0.373
ENSG00000094631 E034 0.0000000       X 48802786 48802870 85 +      
ENSG00000094631 E035 68.2109755 0.0009820749 3.936240e-02 8.984228e-02 X 48802871 48802887 17 + 1.839 1.760 -0.267
ENSG00000094631 E036 67.8083507 0.0051632538 2.965612e-01 4.377959e-01 X 48802888 48802907 20 + 1.810 1.772 -0.131
ENSG00000094631 E037 67.5598228 0.0012885734 2.925595e-01 4.335358e-01 X 48802908 48802919 12 + 1.804 1.771 -0.110
ENSG00000094631 E038 77.2547855 0.0003782323 1.322057e-01 2.371755e-01 X 48802920 48802937 18 + 1.872 1.825 -0.158
ENSG00000094631 E039 107.1681675 0.0003320895 3.585190e-02 8.329759e-02 X 48802938 48802999 62 + 2.022 1.963 -0.198
ENSG00000094631 E040 117.9292536 0.0022717508 5.125572e-01 6.474617e-01 X 48803128 48803216 89 + 2.024 2.017 -0.024
ENSG00000094631 E041 0.1472490 0.0425979866 2.052964e-01   X 48803217 48803439 223 + 0.173 0.000 -13.300
ENSG00000094631 E042 118.3634338 0.0026511234 2.560268e-01 3.929924e-01 X 48805438 48805522 85 + 2.038 2.011 -0.092
ENSG00000094631 E043 93.5835744 0.0015547006 2.519102e-02 6.226418e-02 X 48805631 48805671 41 + 1.971 1.894 -0.258
ENSG00000094631 E044 12.4481918 0.0027845761 1.682155e-02 4.453812e-02 X 48805672 48805779 108 + 1.222 1.004 -0.785
ENSG00000094631 E045 21.9742813 0.0071667928 4.411798e-06 3.179284e-05 X 48805780 48806367 588 + 1.535 1.174 -1.259
ENSG00000094631 E046 85.0269159 0.0003501495 4.913914e-02 1.076203e-01 X 48806368 48806418 51 + 1.923 1.860 -0.212
ENSG00000094631 E047 70.1096244 0.0003891482 1.121876e-01 2.087411e-01 X 48806419 48806464 46 + 1.833 1.779 -0.182
ENSG00000094631 E048 8.3389565 0.0070091440 1.647881e-01 2.814110e-01 X 48806465 48806608 144 + 1.033 0.886 -0.549
ENSG00000094631 E049 86.4165995 0.0016902754 3.414903e-01 4.853833e-01 X 48806609 48806706 98 + 1.899 1.876 -0.080
ENSG00000094631 E050 7.2078264 0.0258857723 9.143824e-01 9.497926e-01 X 48806707 48806959 253 + 0.867 0.873 0.021
ENSG00000094631 E051 87.9130445 0.0083726261 8.018380e-01 8.737399e-01 X 48808033 48808137 105 + 1.888 1.895 0.023
ENSG00000094631 E052 77.3074914 0.0078849422 3.539962e-01 4.982802e-01 X 48808258 48808326 69 + 1.863 1.827 -0.120
ENSG00000094631 E053 0.7353121 0.0925003431 4.239997e-01 5.670020e-01 X 48810630 48810751 122 + 0.296 0.158 -1.159
ENSG00000094631 E054 0.5911862 0.0183032139 3.735096e-03 1.239777e-02 X 48811003 48811072 70 + 0.471 0.000 -15.488
ENSG00000094631 E055 5.0931455 0.0236968510 4.762183e-05 2.697266e-04 X 48813353 48814439 1087 + 1.071 0.501 -2.313
ENSG00000094631 E056 89.6789899 0.0028591864 4.848146e-01 6.227568e-01 X 48814440 48814539 100 + 1.912 1.899 -0.047
ENSG00000094631 E057 48.8975574 0.0049866005 3.175020e-01 4.603924e-01 X 48814540 48814566 27 + 1.681 1.638 -0.146
ENSG00000094631 E058 66.5400698 0.0004293375 2.408308e-01 3.751473e-01 X 48814675 48814740 66 + 1.804 1.768 -0.123
ENSG00000094631 E059 3.4957177 0.0778819532 3.300509e-04 1.501036e-03 X 48814741 48814764 24 + 0.969 0.321 -2.924
ENSG00000094631 E060 10.3749222 0.0016314336 2.738128e-05 1.644205e-04 X 48814765 48814833 69 + 1.258 0.849 -1.499
ENSG00000094631 E061 67.8113977 0.0005340132 5.247353e-02 1.135668e-01 X 48814834 48814893 60 + 1.833 1.761 -0.242
ENSG00000094631 E062 3.6722504 0.0059080015 1.168684e-04 5.994901e-04 X 48814894 48814961 68 + 0.946 0.401 -2.369
ENSG00000094631 E063 70.3026090 0.0003883230 7.658351e-02 1.540264e-01 X 48814962 48815025 64 + 1.842 1.780 -0.209
ENSG00000094631 E064 37.7877612 0.0060202052 2.853813e-02 6.909307e-02 X 48815026 48815028 3 + 1.624 1.492 -0.453
ENSG00000094631 E065 47.5741792 0.0096386295 1.813110e-01 3.028868e-01 X 48815029 48815051 23 + 1.681 1.609 -0.246
ENSG00000094631 E066 19.6739233 0.0009996042 1.171792e-07 1.175310e-06 X 48815052 48815268 217 + 1.510 1.118 -1.370
ENSG00000094631 E067 7.7853821 0.0061646181 4.735784e-01 6.125267e-01 X 48815269 48815279 11 + 0.946 0.875 -0.271
ENSG00000094631 E068 8.9019867 0.0201432078 3.824073e-01 5.266267e-01 X 48815280 48815295 16 + 1.013 0.922 -0.340
ENSG00000094631 E069 13.4235259 0.0080490848 1.033666e-02 2.959795e-02 X 48815296 48815383 88 + 1.270 1.031 -0.856
ENSG00000094631 E070 94.5968510 0.0060980132 7.317269e-01 8.233263e-01 X 48815384 48815490 107 + 1.923 1.925 0.009
ENSG00000094631 E071 80.2634247 0.0004222193 8.525657e-01 9.086422e-01 X 48815575 48815642 68 + 1.845 1.856 0.037
ENSG00000094631 E072 11.8499634 0.0016118314 5.161601e-14 1.529803e-12 X 48815643 48815798 156 + 1.446 0.744 -2.567
ENSG00000094631 E073 12.1345578 0.0232905302 2.370951e-09 3.280526e-08 X 48815799 48815883 85 + 1.446 0.761 -2.500
ENSG00000094631 E074 135.0069556 0.0002605255 8.475325e-01 9.053272e-01 X 48815884 48816052 169 + 2.068 2.081 0.042
ENSG00000094631 E075 77.0631385 0.0003749859 6.188823e-01 7.364245e-01 X 48816141 48816189 49 + 1.804 1.845 0.140
ENSG00000094631 E076 82.4453013 0.0004333132 9.460775e-01 9.701459e-01 X 48816190 48816269 80 + 1.848 1.870 0.074
ENSG00000094631 E077 47.9163721 0.0020243839 2.212736e-01 3.519580e-01 X 48816465 48816469 5 + 1.672 1.620 -0.176
ENSG00000094631 E078 45.2116706 0.0006361162 9.353967e-02 1.806539e-01 X 48816470 48816472 3 + 1.663 1.587 -0.258
ENSG00000094631 E079 87.3727270 0.0088196539 7.297929e-01 8.219069e-01 X 48816473 48816569 97 + 1.886 1.890 0.014
ENSG00000094631 E080 60.2029173 0.0090246352 2.788200e-01 4.184851e-01 X 48816570 48816633 64 + 1.654 1.753 0.336
ENSG00000094631 E081 4.5532277 0.0052743612 4.805541e-05 2.719547e-04 X 48816634 48816953 320 + 1.013 0.470 -2.255
ENSG00000094631 E082 4.6887322 0.0037369263 9.773756e-03 2.820639e-02 X 48816960 48817325 366 + 0.921 0.581 -1.383
ENSG00000094631 E083 49.2301771 0.0032851217 6.089555e-02 1.281447e-01 X 48817326 48817359 34 + 1.535 1.675 0.477
ENSG00000094631 E084 80.9483704 0.0102616849 1.619825e-01 2.777037e-01 X 48817360 48817459 100 + 1.765 1.885 0.405
ENSG00000094631 E085 8.9155117 0.0025808987 8.764233e-09 1.092125e-07 X 48817638 48818040 403 + 1.292 0.690 -2.255
ENSG00000094631 E086 55.8540065 0.0009188923 2.583971e-01 3.956401e-01 X 48818041 48818070 30 + 1.634 1.715 0.275
ENSG00000094631 E087 73.8330029 0.0009687424 9.175361e-01 9.518942e-01 X 48818071 48818109 39 + 1.797 1.821 0.081
ENSG00000094631 E088 3.9221884 0.0041621454 1.028853e-04 5.353517e-04 X 48818110 48818219 110 + 0.970 0.436 -2.266
ENSG00000094631 E089 80.8131066 0.0052757611 3.901321e-01 5.341506e-01 X 48818220 48818312 93 + 1.804 1.873 0.233
ENSG00000094631 E090 91.2190641 0.0006783912 2.887146e-01 4.293360e-01 X 48818313 48818412 100 + 1.857 1.922 0.218
ENSG00000094631 E091 19.0836025 0.0362282873 4.280507e-07 3.837153e-06 X 48819447 48820105 659 + 1.582 1.008 -2.018
ENSG00000094631 E092 135.4408403 0.0002941350 1.287019e-01 2.323463e-01 X 48820106 48820255 150 + 2.024 2.096 0.241
ENSG00000094631 E093 180.1796967 0.0002304410 4.269961e-01 5.698385e-01 X 48822620 48822794 175 + 2.171 2.214 0.143
ENSG00000094631 E094 175.5498474 0.0002493908 2.763613e-01 4.158160e-01 X 48822912 48823018 107 + 2.202 2.189 -0.043
ENSG00000094631 E095 103.2357201 0.0014914905 6.982846e-01 7.982760e-01 X 48823019 48823031 13 + 1.962 1.965 0.012
ENSG00000094631 E096 177.7935196 0.0029333800 7.007787e-01 8.001685e-01 X 48823032 48823120 89 + 2.171 2.208 0.121
ENSG00000094631 E097 397.0581842 0.0038139438 9.930432e-03 2.858974e-02 X 48823121 48823517 397 + 2.462 2.574 0.373
ENSG00000094631 E098 125.6690356 0.0044317468 3.923757e-03 1.292844e-02 X 48823518 48823528 11 + 1.925 2.088 0.546
ENSG00000094631 E099 158.9059950 0.0024027658 4.766735e-05 2.699440e-04 X 48823529 48823588 60 + 2.008 2.194 0.623
ENSG00000094631 E100 190.7085694 0.0058369385 2.916425e-05 1.740402e-04 X 48823672 48823785 114 + 2.055 2.280 0.752
ENSG00000094631 E101 213.8143771 0.0067960280 4.271516e-04 1.878761e-03 X 48823922 48824068 147 + 2.128 2.324 0.656
ENSG00000094631 E102 221.1843486 0.0077407808 6.579462e-03 2.013341e-02 X 48824166 48824294 129 + 2.170 2.332 0.541
ENSG00000094631 E103 335.2258142 0.0048641627 2.316690e-08 2.667584e-07 X 48824544 48824982 439 + 2.276 2.527 0.837