ENSG00000093183

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264454 ENSG00000093183 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22C protein_coding protein_coding 28.78445 26.28592 30.26275 2.995667 0.3428615 0.2031813 7.2732181 2.224890 11.8460358 1.3674625 0.9880973 2.407346 0.24748333 0.09953333 0.39120000 0.29166667 3.366004e-01 1.818708e-12 FALSE TRUE
ENST00000273156 ENSG00000093183 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22C protein_coding protein_coding 28.78445 26.28592 30.26275 2.995667 0.3428615 0.2031813 11.4007598 14.318441 8.4297293 1.9160111 1.0039484 -0.763613 0.40353750 0.54340000 0.27930000 -0.26410000 1.089824e-04 1.818708e-12 FALSE TRUE
ENST00000451653 ENSG00000093183 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22C protein_coding protein_coding 28.78445 26.28592 30.26275 2.995667 0.3428615 0.2031813 2.8893640 3.806643 0.3101969 2.2755021 0.3101969 -3.575273 0.09752917 0.12830000 0.01023333 -0.11806667 3.948631e-01 1.818708e-12 FALSE TRUE
MSTRG.22811.11 ENSG00000093183 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22C protein_coding   28.78445 26.28592 30.26275 2.995667 0.3428615 0.2031813 0.7620176 1.783259 0.0000000 0.4475967 0.0000000 -7.486440 0.02922917 0.06966667 0.00000000 -0.06966667 1.818708e-12 1.818708e-12 FALSE TRUE
MSTRG.22811.12 ENSG00000093183 HEK293_OSMI2_2hA HEK293_TMG_2hB SEC22C protein_coding   28.78445 26.28592 30.26275 2.995667 0.3428615 0.2031813 2.0380171 1.384493 4.0607510 0.2259649 0.9326889 1.545554 0.06959583 0.05220000 0.13380000 0.08160000 2.168392e-02 1.818708e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000093183 E001 0.8416995 0.0374505380 1.468388e-02 3.977604e-02 3 42547969 42547970 2 - 0.000 0.421 10.727
ENSG00000093183 E002 1.4371521 0.0108703801 6.424802e-01 7.552474e-01 3 42547971 42547983 13 - 0.360 0.422 0.345
ENSG00000093183 E003 22.0627157 0.0127700414 5.196060e-01 6.536809e-01 3 42547984 42548003 20 - 1.355 1.377 0.075
ENSG00000093183 E004 86.0590027 0.0003492880 2.410577e-04 1.137794e-03 3 42548004 42548141 138 - 1.884 1.991 0.362
ENSG00000093183 E005 113.8945596 0.0003602416 1.966252e-07 1.886557e-06 3 42548142 42548182 41 - 1.985 2.127 0.478
ENSG00000093183 E006 93.5619531 0.0017257368 1.299692e-05 8.406092e-05 3 42548183 42548189 7 - 1.896 2.044 0.495
ENSG00000093183 E007 95.2156127 0.0004682461 2.617531e-04 1.223738e-03 3 42548190 42548203 14 - 1.932 2.034 0.342
ENSG00000093183 E008 162.6514349 0.0027748949 4.663412e-04 2.031384e-03 3 42548204 42548310 107 - 2.163 2.260 0.325
ENSG00000093183 E009 66.3520647 0.0009315038 7.720777e-03 2.307791e-02 3 42548311 42548313 3 - 1.788 1.875 0.294
ENSG00000093183 E010 149.9001647 0.0005443641 1.322031e-04 6.684680e-04 3 42548314 42548377 64 - 2.139 2.222 0.278
ENSG00000093183 E011 285.9833997 0.0014937891 5.754899e-05 3.193463e-04 3 42548378 42548657 280 - 2.420 2.494 0.248
ENSG00000093183 E012 363.8161638 0.0060379688 5.782495e-04 2.453364e-03 3 42548658 42549841 1184 - 2.647 2.477 -0.566
ENSG00000093183 E013 894.5295896 0.0019773934 6.134171e-25 6.682578e-23 3 42549842 42553253 3412 - 3.074 2.815 -0.860
ENSG00000093183 E014 150.2675026 0.0002569268 1.234587e-02 3.436258e-02 3 42553254 42553406 153 - 2.163 2.202 0.131
ENSG00000093183 E015 95.2211801 0.0024777304 2.375343e-01 3.712986e-01 3 42553407 42553448 42 - 1.977 1.990 0.044
ENSG00000093183 E016 114.4681872 0.0031855291 1.779954e-02 4.670521e-02 3 42555930 42555930 1 - 2.029 2.088 0.199
ENSG00000093183 E017 202.6230367 0.0014429522 9.375991e-03 2.722311e-02 3 42555931 42555995 65 - 2.288 2.329 0.136
ENSG00000093183 E018 251.5961107 0.0001841063 2.081745e-07 1.988907e-06 3 42557578 42557696 119 - 2.360 2.443 0.276
ENSG00000093183 E019 0.4847352 0.2616503111 7.100850e-01 8.073039e-01 3 42561115 42561116 2 - 0.217 0.124 -0.976
ENSG00000093183 E020 222.3689374 0.0001828985 3.685394e-04 1.652518e-03 3 42561117 42561214 98 - 2.326 2.377 0.171
ENSG00000093183 E021 203.7702469 0.0005102261 6.524869e-02 1.354500e-01 3 42561215 42561296 82 - 2.308 2.324 0.051
ENSG00000093183 E022 113.6746879 0.0004054729 3.086395e-01 4.509133e-01 3 42563523 42563523 1 - 2.062 2.062 0.003
ENSG00000093183 E023 121.8130147 0.0003155672 2.516544e-01 3.879184e-01 3 42563524 42563544 21 - 2.090 2.093 0.012
ENSG00000093183 E024 104.5322537 0.0003117015 3.790481e-01 5.233434e-01 3 42563545 42563546 2 - 2.030 2.028 -0.008
ENSG00000093183 E025 172.5338923 0.0004441011 7.974064e-02 1.591516e-01 3 42563547 42563608 62 - 2.234 2.249 0.049
ENSG00000093183 E026 162.9051069 0.0006822711 9.650762e-01 9.820214e-01 3 42563609 42563686 78 - 2.234 2.200 -0.112
ENSG00000093183 E027 21.0622644 0.0008988796 4.734219e-04 2.058536e-03 3 42563765 42563810 46 - 1.482 1.188 -1.025
ENSG00000093183 E028 18.6160133 0.0009605543 6.068230e-04 2.557982e-03 3 42563811 42563844 34 - 1.434 1.129 -1.068
ENSG00000093183 E029 22.4848425 0.0008121708 7.834921e-04 3.200445e-03 3 42563845 42563880 36 - 1.500 1.224 -0.961
ENSG00000093183 E030 18.9552963 0.0010025156 1.810419e-03 6.632218e-03 3 42563881 42563888 8 - 1.428 1.150 -0.976
ENSG00000093183 E031 19.5126038 0.0058740946 5.803642e-03 1.809639e-02 3 42563889 42563926 38 - 1.439 1.169 -0.941
ENSG00000093183 E032 19.7545738 0.0153903167 2.733699e-02 6.668098e-02 3 42563927 42563980 54 - 1.438 1.187 -0.878
ENSG00000093183 E033 10.6879599 0.0021804487 5.673870e-02 1.210102e-01 3 42563981 42564415 435 - 1.172 0.948 -0.817
ENSG00000093183 E034 2.6644620 0.0187664595 3.268557e-01 4.702947e-01 3 42565776 42565883 108 - 0.658 0.472 -0.853
ENSG00000093183 E035 3.8332265 0.0043993051 9.804757e-01 9.917660e-01 3 42566744 42566836 93 - 0.688 0.664 -0.100
ENSG00000093183 E036 260.1394830 0.0028383271 6.347117e-01 7.491153e-01 3 42568865 42569073 209 - 2.431 2.404 -0.092
ENSG00000093183 E037 0.4815130 0.0204702801 5.151562e-01 6.498522e-01 3 42573400 42573547 148 - 0.121 0.219 1.023
ENSG00000093183 E038 1.9229184 0.0081845971 4.697551e-01 6.089828e-01 3 42579477 42579593 117 - 0.417 0.518 0.508
ENSG00000093183 E039 1.2365213 0.4776974479 4.906449e-01 6.279850e-01 3 42580443 42580505 63 - 0.465 0.221 -1.537
ENSG00000093183 E040 0.9921577 0.0126962940 3.550014e-01 4.993425e-01 3 42581312 42581365 54 - 0.216 0.364 1.024
ENSG00000093183 E041 113.9082392 0.0044335556 1.043824e-01 1.971628e-01 3 42581846 42582028 183 - 2.043 2.075 0.107
ENSG00000093183 E042 7.5273097 0.0025844617 9.052256e-01 9.436745e-01 3 42582193 42584390 2198 - 0.957 0.915 -0.161
ENSG00000093183 E043 0.0000000       3 42587411 42587562 152 -      
ENSG00000093183 E044 6.1567991 0.0027135792 6.255367e-03 1.928339e-02 3 42600411 42600524 114 - 0.658 0.979 1.264
ENSG00000093183 E045 5.5304107 0.0029358032 1.154134e-01 2.134434e-01 3 42600960 42601080 121 - 0.925 0.694 -0.914