ENSG00000093167

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000421276 ENSG00000093167 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRFIP2 protein_coding protein_coding 31.66559 29.15762 42.08107 0.610112 0.8481172 0.5291463 12.555353 13.1605132 13.829455 0.23189760 0.0728605 0.07147561 0.40774167 0.45143333 0.32883333 -0.122600000 3.915394e-08 1.523196e-22 FALSE TRUE
ENST00000490597 ENSG00000093167 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRFIP2 protein_coding processed_transcript 31.66559 29.15762 42.08107 0.610112 0.8481172 0.5291463 1.905022 1.0772351 3.720484 0.14740496 0.1218673 1.77869890 0.05517500 0.03720000 0.08843333 0.051233333 2.253343e-04 1.523196e-22   FALSE
ENST00000496825 ENSG00000093167 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRFIP2 protein_coding processed_transcript 31.66559 29.15762 42.08107 0.610112 0.8481172 0.5291463 2.453699 3.0313369 2.618338 0.15877893 0.3887750 -0.21055457 0.07953333 0.10410000 0.06186667 -0.042233333 3.752460e-02 1.523196e-22   FALSE
MSTRG.22700.13 ENSG00000093167 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRFIP2 protein_coding   31.66559 29.15762 42.08107 0.610112 0.8481172 0.5291463 3.434260 2.5778174 4.006571 0.39242783 0.1392784 0.63422857 0.10820000 0.08896667 0.09543333 0.006466667 8.966475e-01 1.523196e-22 FALSE TRUE
MSTRG.22700.25 ENSG00000093167 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRFIP2 protein_coding   31.66559 29.15762 42.08107 0.610112 0.8481172 0.5291463 1.888894 0.5349941 3.906446 0.04161221 0.1963249 2.84523261 0.05244167 0.01833333 0.09273333 0.074400000 5.611389e-17 1.523196e-22   FALSE
MSTRG.22700.31 ENSG00000093167 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRFIP2 protein_coding   31.66559 29.15762 42.08107 0.610112 0.8481172 0.5291463 2.131136 4.0339539 1.604582 0.27554557 0.2347144 -1.32460603 0.07362083 0.13803333 0.03836667 -0.099666667 3.823670e-08 1.523196e-22   FALSE
MSTRG.22700.7 ENSG00000093167 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRFIP2 protein_coding   31.66559 29.15762 42.08107 0.610112 0.8481172 0.5291463 1.059277 0.0000000 2.526800 0.00000000 0.2870863 7.98686577 0.02951250 0.00000000 0.06036667 0.060366667 1.789686e-18 1.523196e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000093167 E001 1.2063323 0.1233153787 9.430845e-02 1.818455e-01 3 37052626 37052655 30 - 0.482 0.135 -2.483
ENSG00000093167 E002 11.9745894 0.0234032112 3.097597e-01 4.521035e-01 3 37052656 37053003 348 - 1.167 1.049 -0.426
ENSG00000093167 E003 261.6583518 0.0017495179 5.880021e-11 1.077532e-09 3 37053004 37053605 602 - 2.314 2.506 0.643
ENSG00000093167 E004 112.7879706 0.0002963808 1.645962e-06 1.303878e-05 3 37053606 37053686 81 - 1.967 2.131 0.547
ENSG00000093167 E005 69.1075036 0.0003633396 3.687058e-04 1.653142e-03 3 37053687 37053720 34 - 1.764 1.918 0.518
ENSG00000093167 E006 84.0103054 0.0003166314 5.808798e-04 2.463090e-03 3 37053721 37053749 29 - 1.858 1.993 0.454
ENSG00000093167 E007 258.0210573 0.0030943146 1.135727e-02 3.202071e-02 3 37053750 37053961 212 - 2.369 2.458 0.298
ENSG00000093167 E008 219.6958591 0.0036305703 3.129665e-02 7.447760e-02 3 37054411 37054515 105 - 2.303 2.385 0.274
ENSG00000093167 E009 188.9145219 0.0002121010 1.989300e-03 7.193627e-03 3 37055086 37055165 80 - 2.236 2.318 0.274
ENSG00000093167 E010 179.5908878 0.0009950656 2.729623e-02 6.659613e-02 3 37058790 37058858 69 - 2.219 2.287 0.226
ENSG00000093167 E011 153.8124869 0.0012314477 1.684454e-01 2.861514e-01 3 37058859 37058910 52 - 2.165 2.212 0.157
ENSG00000093167 E012 155.9710042 0.0002282282 4.777462e-01 6.162665e-01 3 37063742 37063791 50 - 2.185 2.208 0.076
ENSG00000093167 E013 4.2647697 0.0339929220 9.674549e-01 9.836542e-01 3 37063792 37065334 1543 - 0.730 0.727 -0.015
ENSG00000093167 E014 185.5460182 0.0003506220 3.380801e-02 7.937374e-02 3 37065810 37065942 133 - 2.239 2.298 0.197
ENSG00000093167 E015 7.4878771 0.0041715831 2.443980e-02 6.073147e-02 3 37065943 37066223 281 - 1.049 0.784 -1.005
ENSG00000093167 E016 8.1006638 0.0050965628 5.515815e-01 6.810095e-01 3 37066224 37066325 102 - 0.933 1.003 0.260
ENSG00000093167 E017 34.4295687 0.0011526662 2.098876e-12 4.884237e-11 3 37066326 37068763 2438 - 1.718 1.266 -1.556
ENSG00000093167 E018 5.1126011 0.0036520960 1.697854e-02 4.488666e-02 3 37072790 37072846 57 - 0.918 0.592 -1.325
ENSG00000093167 E019 6.8767319 0.0106026478 2.732153e-02 6.665098e-02 3 37072847 37072882 36 - 1.014 0.730 -1.095
ENSG00000093167 E020 149.4306088 0.0005189577 7.372033e-02 1.494803e-01 3 37075024 37075116 93 - 2.146 2.202 0.187
ENSG00000093167 E021 87.9592754 0.0015910687 9.923087e-01 9.992766e-01 3 37083636 37083644 9 - 1.944 1.945 0.005
ENSG00000093167 E022 204.9501071 0.0029090727 5.227666e-01 6.565104e-01 3 37083645 37083806 162 - 2.299 2.323 0.082
ENSG00000093167 E023 108.2044571 0.0011433488 2.929714e-03 1.005718e-02 3 37091467 37091538 72 - 2.086 1.977 -0.365
ENSG00000093167 E024 199.2625757 0.0015491887 6.410674e-03 1.968897e-02 3 37094792 37094908 117 - 2.338 2.257 -0.271
ENSG00000093167 E025 123.6001029 0.0002712547 4.221391e-02 9.511732e-02 3 37096616 37096660 45 - 2.124 2.061 -0.209
ENSG00000093167 E026 0.3686942 0.0313041081 8.738930e-01 9.229472e-01 3 37102924 37103013 90 - 0.111 0.135 0.322
ENSG00000093167 E027 5.0347422 0.0049764247 1.304083e-01 2.347223e-01 3 37105455 37105523 69 - 0.870 0.666 -0.819
ENSG00000093167 E028 4.2480479 0.1177118518 3.262784e-01 4.697317e-01 3 37108073 37108129 57 - 0.815 0.621 -0.799
ENSG00000093167 E029 5.9359553 0.0029089416 8.310119e-03 2.456865e-02 3 37108637 37108684 48 - 0.975 0.631 -1.369
ENSG00000093167 E030 0.3666179 0.0308373219 8.732351e-01 9.225711e-01 3 37109527 37109571 45 - 0.111 0.135 0.322
ENSG00000093167 E031 2.5297247 0.0917784344 3.041363e-03 1.038681e-02 3 37109653 37109703 51 - 0.752 0.135 -3.675
ENSG00000093167 E032 3.3162431 0.0053358530 3.518850e-02 8.200204e-02 3 37110991 37111065 75 - 0.775 0.450 -1.448
ENSG00000093167 E033 0.1451727 0.0433776413 5.955715e-01   3 37111826 37111915 90 - 0.111 0.000 -10.881
ENSG00000093167 E034 3.0248535 0.0050631473 2.252976e-02 5.678132e-02 3 37112915 37112980 66 - 0.753 0.390 -1.682
ENSG00000093167 E035 0.2903454 0.3454914554 3.596854e-01   3 37115054 37115095 42 - 0.199 0.000 -11.876
ENSG00000093167 E036 0.8878743 0.0131163640 1.551769e-02 4.166827e-02 3 37121464 37121491 28 - 0.439 0.000 -13.466
ENSG00000093167 E037 16.2784800 0.0011010661 1.065142e-04 5.519933e-04 3 37121492 37121536 45 - 1.370 1.034 -1.193
ENSG00000093167 E038 13.7018180 0.0015037550 9.797145e-05 5.125341e-04 3 37121635 37121665 31 - 1.306 0.936 -1.332
ENSG00000093167 E039 11.5907759 0.0016909808 1.379498e-04 6.945677e-04 3 37121666 37121691 26 - 1.246 0.856 -1.426
ENSG00000093167 E040 0.1451727 0.0433776413 5.955715e-01   3 37127630 37127680 51 - 0.111 0.000 -10.881
ENSG00000093167 E041 160.5638686 0.0007843818 2.616194e-03 9.114703e-03 3 37129063 37129149 87 - 2.249 2.160 -0.298
ENSG00000093167 E042 11.1844023 0.0045647512 2.907394e-12 6.614591e-11 3 37146329 37146425 97 - 1.324 0.450 -3.467
ENSG00000093167 E043 6.6234795 0.0037790168 4.085235e-08 4.486063e-07 3 37146426 37146453 28 - 1.112 0.320 -3.454
ENSG00000093167 E044 21.8008035 0.0009103098 3.519084e-16 1.411859e-14 3 37146454 37146627 174 - 1.573 0.878 -2.477
ENSG00000093167 E045 118.9271507 0.0026563857 1.057060e-04 5.482431e-04 3 37148894 37148926 33 - 2.150 1.995 -0.518
ENSG00000093167 E046 174.4448191 0.0020543909 1.379054e-06 1.111025e-05 3 37148927 37149038 112 - 2.317 2.156 -0.540
ENSG00000093167 E047 13.1902905 0.0014682538 7.825394e-03 2.334274e-02 3 37154614 37154656 43 - 1.253 1.004 -0.895
ENSG00000093167 E048 7.1048736 0.0083518429 7.947252e-03 2.364704e-02 3 37154657 37154724 68 - 1.038 0.699 -1.308
ENSG00000093167 E049 57.7228287 0.0024042312 1.946846e-11 3.865676e-10 3 37170333 37171066 734 - 1.912 1.558 -1.199
ENSG00000093167 E050 4.3231520 0.0040715809 7.744758e-03 2.313645e-02 3 37172770 37172790 21 - 0.887 0.502 -1.621
ENSG00000093167 E051 51.1008047 0.0004518829 2.208448e-12 5.124114e-11 3 37172791 37173026 236 - 1.504 1.861 1.213
ENSG00000093167 E052 30.7957013 0.0006782135 2.607476e-16 1.067831e-14 3 37173027 37173194 168 - 1.140 1.697 1.926
ENSG00000093167 E053 0.6028395 0.4599663111 6.342724e-01 7.487833e-01 3 37174119 37174538 420 - 0.274 0.132 -1.311
ENSG00000093167 E054 168.3667952 0.0003120258 3.596728e-01 5.039937e-01 3 37174539 37174605 67 - 2.239 2.216 -0.077
ENSG00000093167 E055 1.0382438 0.0120585802 8.881844e-02 1.733107e-01 3 37174717 37175162 446 - 0.439 0.135 -2.267
ENSG00000093167 E056 0.2987644 0.0272984459 2.659216e-01   3 37175163 37175215 53 - 0.199 0.000 -11.881
ENSG00000093167 E057 25.4122587 0.0016728694 4.571065e-06 3.283689e-05 3 37175818 37176059 242 - 1.552 1.221 -1.150
ENSG00000093167 E058 149.5447992 0.0042954807 1.476673e-01 2.585215e-01 3 37176060 37176360 301 - 2.203 2.144 -0.198
ENSG00000093167 E059 1.6145875 0.0086390450 2.879283e-04 1.330808e-03 3 37176369 37176532 164 - 0.000 0.631 14.415
ENSG00000093167 E060 0.0000000       3 37183542 37183689 148 -