ENSG00000093144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368291 ENSG00000093144 HEK293_OSMI2_2hA HEK293_TMG_2hB ECHDC1 protein_coding protein_coding 36.51624 23.18712 49.30471 1.673426 2.133225 1.088073 12.029421 8.977392 11.766522 0.7184062 0.5542295 0.3899391 0.34835833 0.3895333 0.23940000 -0.15013333 0.007381369 0.007381369 FALSE TRUE
ENST00000430841 ENSG00000093144 HEK293_OSMI2_2hA HEK293_TMG_2hB ECHDC1 protein_coding protein_coding 36.51624 23.18712 49.30471 1.673426 2.133225 1.088073 2.384762 2.281151 1.386734 0.4625524 1.3867341 -0.7140153 0.07554167 0.1013000 0.03036667 -0.07093333 0.128407397 0.007381369 FALSE TRUE
ENST00000454859 ENSG00000093144 HEK293_OSMI2_2hA HEK293_TMG_2hB ECHDC1 protein_coding protein_coding 36.51624 23.18712 49.30471 1.673426 2.133225 1.088073 16.145834 9.217943 26.264120 1.1586804 1.3299379 1.5095614 0.41405417 0.3960000 0.53263333 0.13663333 0.018144075 0.007381369 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000093144 E001 1.4025819 0.1136443489 1.256661e-01 2.280955e-01 6 127288712 127288719 8 - 0.235 0.557 1.859
ENSG00000093144 E002 22.7151887 0.0168453723 5.360358e-01 6.678133e-01 6 127288720 127288761 42 - 1.396 1.341 -0.193
ENSG00000093144 E003 260.5913500 0.0028874162 1.435420e-01 2.528346e-01 6 127288762 127289266 505 - 2.430 2.382 -0.160
ENSG00000093144 E004 238.6449533 0.0006282156 3.434162e-09 4.610202e-08 6 127289267 127289631 365 - 2.427 2.265 -0.540
ENSG00000093144 E005 63.1487713 0.0120813575 1.852239e-04 9.000924e-04 6 127289632 127289633 2 - 1.888 1.600 -0.976
ENSG00000093144 E006 153.5319235 0.0003594094 1.306443e-09 1.895403e-08 6 127289634 127289779 146 - 2.246 2.051 -0.651
ENSG00000093144 E007 130.9433566 0.0004424818 6.527890e-01 7.634449e-01 6 127289780 127289868 89 - 2.118 2.100 -0.060
ENSG00000093144 E008 80.0427292 0.0003686235 3.314118e-02 7.808591e-02 6 127289869 127289876 8 - 1.865 1.948 0.278
ENSG00000093144 E009 203.5258794 0.0002003027 2.172982e-01 3.471388e-01 6 127289877 127289928 52 - 2.292 2.320 0.095
ENSG00000093144 E010 260.6382186 0.0001650362 3.876527e-02 8.875096e-02 6 127289929 127289987 59 - 2.393 2.436 0.144
ENSG00000093144 E011 274.0212610 0.0001561408 2.965123e-02 7.128237e-02 6 127289988 127290045 58 - 2.415 2.459 0.147
ENSG00000093144 E012 169.6086269 0.0006834328 3.218075e-01 4.650688e-01 6 127290046 127290049 4 - 2.216 2.243 0.089
ENSG00000093144 E013 261.4504270 0.0001764931 4.157372e-05 2.386671e-04 6 127290050 127290109 60 - 2.376 2.464 0.293
ENSG00000093144 E014 418.5807742 0.0001345693 1.302763e-05 8.423649e-05 6 127290110 127290277 168 - 2.586 2.659 0.242
ENSG00000093144 E015 1.0352370 0.1095341304 4.600253e-02 1.020416e-01 6 127294504 127294744 241 - 0.427 0.000 -12.320
ENSG00000093144 E016 2.9299290 0.0058077443 7.553287e-01 8.407002e-01 6 127313066 127313591 526 - 0.614 0.563 -0.229
ENSG00000093144 E017 232.8903703 0.0001618601 1.730111e-01 2.921094e-01 6 127314816 127314854 39 - 2.350 2.379 0.097
ENSG00000093144 E018 170.0291979 0.0001959915 8.025985e-01 8.742619e-01 6 127314855 127314858 4 - 2.225 2.229 0.014
ENSG00000093144 E019 177.3830049 0.0001956352 3.161413e-01 4.589019e-01 6 127314859 127314865 7 - 2.236 2.260 0.081
ENSG00000093144 E020 200.2129613 0.0001776801 1.649572e-01 2.816440e-01 6 127314866 127314896 31 - 2.283 2.315 0.108
ENSG00000093144 E021 1.8069791 0.0081197784 4.768555e-01 6.154753e-01 6 127314897 127315134 238 - 0.387 0.507 0.625
ENSG00000093144 E022 0.6235652 0.0193874923 6.859733e-01 7.885703e-01 6 127315135 127315138 4 - 0.235 0.159 -0.697
ENSG00000093144 E023 4.4350269 0.0371227198 6.391171e-02 1.332103e-01 6 127315139 127315860 722 - 0.829 0.507 -1.377
ENSG00000093144 E024 5.5369678 0.0039105217 9.387012e-01 9.655138e-01 6 127315934 127315974 41 - 0.813 0.800 -0.051
ENSG00000093144 E025 1.4843710 0.0087076336 7.089841e-02 1.448342e-01 6 127315975 127316081 107 - 0.499 0.159 -2.283
ENSG00000093144 E026 0.5985731 0.0234843498 6.795235e-01 7.836713e-01 6 127316256 127316449 194 - 0.235 0.159 -0.700
ENSG00000093144 E027 112.0783769 0.0002607815 3.754019e-01 5.198360e-01 6 127316450 127316458 9 - 2.058 2.025 -0.113
ENSG00000093144 E028 152.2120074 0.0002894634 1.929912e-01 3.175266e-01 6 127316459 127316502 44 - 2.193 2.150 -0.142
ENSG00000093144 E029 1.2639554 0.0106657247 5.486777e-01 6.785166e-01 6 127326496 127326574 79 - 0.387 0.275 -0.697
ENSG00000093144 E030 0.1515154 0.0428918607 9.468134e-01   6 127326881 127326997 117 - 0.093 0.000 -9.513
ENSG00000093144 E031 0.3299976 0.0274424043 7.954672e-02   6 127326998 127327001 4 - 0.000 0.275 12.011
ENSG00000093144 E032 348.0609004 0.0001665980 7.716162e-01 8.525964e-01 6 127327002 127327144 143 - 2.536 2.538 0.009
ENSG00000093144 E033 1.1040340 0.0148498188 7.285524e-01 8.209881e-01 6 127329822 127329882 61 - 0.342 0.275 -0.434
ENSG00000093144 E034 294.8775835 0.0002409784 3.630392e-01 5.074685e-01 6 127330809 127331030 222 - 2.473 2.450 -0.078
ENSG00000093144 E035 5.4983609 0.0029116066 2.498243e-01 3.857062e-01 6 127331830 127331867 38 - 0.859 0.698 -0.643
ENSG00000093144 E036 0.1817044 0.0417232833 2.614965e-01   6 127341569 127341638 70 - 0.000 0.159 11.014
ENSG00000093144 E037 0.7384326 0.0404849775 1.108132e-01 2.067382e-01 6 127342356 127342875 520 - 0.093 0.368 2.478
ENSG00000093144 E038 4.4026442 0.0037310730 7.561227e-01 8.412776e-01 6 127342961 127343335 375 - 0.744 0.697 -0.191
ENSG00000093144 E039 134.8790902 0.0002454931 5.093064e-03 1.618522e-02 6 127343336 127343609 274 - 2.159 2.066 -0.311