ENSG00000093009

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263201 ENSG00000093009 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC45 protein_coding protein_coding 105.2592 129.0759 105.4734 17.93162 0.7000782 -0.2913149 72.021022 90.59602 71.423580 14.386858 1.861866 -0.3430045 0.68232917 0.6973333 0.67746667 -0.01986667 8.341350e-01 1.351772e-69 FALSE TRUE
ENST00000404724 ENSG00000093009 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC45 protein_coding protein_coding 105.2592 129.0759 105.4734 17.93162 0.7000782 -0.2913149 10.473657 17.05421 7.625065 1.704725 1.083989 -1.1602612 0.09817500 0.1348000 0.07223333 -0.06256667 1.754416e-02 1.351772e-69 FALSE TRUE
ENST00000483431 ENSG00000093009 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC45 protein_coding processed_transcript 105.2592 129.0759 105.4734 17.93162 0.7000782 -0.2913149 3.851725 0.00000 11.178622 0.000000 0.678610 10.1278167 0.03722083 0.0000000 0.10610000 0.10610000 1.351772e-69 1.351772e-69 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000093009 E001 0.0000000       22 19479457 19479458 2 +      
ENSG00000093009 E002 0.1515154 0.0433158645 3.282958e-01   22 19479459 19479483 25 + 0.148 0.000 -10.790
ENSG00000093009 E003 0.3030308 0.3824105322 1.850733e-01   22 19479484 19479571 88 + 0.259 0.000 -11.826
ENSG00000093009 E004 1.2876999 0.0108788830 9.342439e-01 9.625545e-01 22 19479738 19479825 88 + 0.346 0.363 0.101
ENSG00000093009 E005 3.0172737 0.0052773557 4.640326e-01 6.037829e-01 22 19479826 19479888 63 + 0.667 0.557 -0.483
ENSG00000093009 E006 4.5524681 0.0047230455 9.760113e-01 9.890263e-01 22 19479889 19479898 10 + 0.737 0.735 -0.007
ENSG00000093009 E007 6.4731833 0.0026596447 8.957787e-01 9.374176e-01 22 19479899 19479900 2 + 0.874 0.861 -0.050
ENSG00000093009 E008 23.5623350 0.0008836624 9.556396e-04 3.807185e-03 22 19479901 19479909 9 + 1.513 1.285 -0.791
ENSG00000093009 E009 31.8773122 0.0045601938 5.234806e-06 3.708051e-05 22 19479910 19479915 6 + 1.678 1.365 -1.072
ENSG00000093009 E010 44.1864679 0.0050280107 2.003392e-06 1.558160e-05 22 19479916 19479919 4 + 1.808 1.509 -1.015
ENSG00000093009 E011 97.9673015 0.0050817456 1.661203e-03 6.157380e-03 22 19479920 19479927 8 + 2.077 1.911 -0.556
ENSG00000093009 E012 139.2911914 0.0028138823 2.680082e-04 1.249467e-03 22 19479928 19479937 10 + 2.221 2.071 -0.502
ENSG00000093009 E013 467.2101155 0.0036960884 1.294633e-05 8.377946e-05 22 19479938 19480019 82 + 2.747 2.591 -0.518
ENSG00000093009 E014 11.1308623 0.0016941272 8.211888e-04 3.335180e-03 22 19480020 19480149 130 + 1.246 0.920 -1.184
ENSG00000093009 E015 7.4867377 0.0022750306 7.663441e-02 1.541085e-01 22 19480150 19480157 8 + 1.031 0.829 -0.760
ENSG00000093009 E016 543.6891068 0.0030114409 4.908792e-05 2.771355e-04 22 19480158 19480217 60 + 2.799 2.667 -0.439
ENSG00000093009 E017 0.7750806 0.0208487859 6.642053e-02 1.374279e-01 22 19480686 19480779 94 + 0.419 0.101 -2.634
ENSG00000093009 E018 643.4021077 0.0035369074 1.816271e-02 4.748046e-02 22 19480953 19481045 93 + 2.842 2.760 -0.274
ENSG00000093009 E019 520.4339047 0.0005916960 5.956287e-04 2.517347e-03 22 19482690 19482750 61 + 2.745 2.677 -0.226
ENSG00000093009 E020 646.3519458 0.0015142254 1.231825e-04 6.284756e-04 22 19482751 19482827 77 + 2.853 2.758 -0.315
ENSG00000093009 E021 1006.6870854 0.0002245311 3.806325e-08 4.200727e-07 22 19483862 19484005 144 + 3.034 2.964 -0.233
ENSG00000093009 E022 466.7272450 0.0014766349 2.609769e-02 6.414366e-02 22 19494327 19494329 3 + 2.690 2.635 -0.183
ENSG00000093009 E023 700.5166267 0.0013045381 2.966134e-02 7.129936e-02 22 19494330 19494382 53 + 2.862 2.812 -0.166
ENSG00000093009 E024 0.8200183 0.0160086014 3.507127e-01 4.948974e-01 22 19494474 19494506 33 + 0.346 0.183 -1.219
ENSG00000093009 E025 4.1351114 0.0041546076 1.992104e-01 3.252423e-01 22 19494507 19494602 96 + 0.797 0.617 -0.749
ENSG00000093009 E026 595.8318519 0.0001846244 5.380131e-01 6.694820e-01 22 19495981 19496029 49 + 2.769 2.761 -0.024
ENSG00000093009 E027 645.9658609 0.0001449450 8.209096e-01 8.870976e-01 22 19497386 19497447 62 + 2.799 2.799 -0.003
ENSG00000093009 E028 722.0720476 0.0005182794 7.957982e-01 8.696061e-01 22 19499101 19499151 51 + 2.842 2.848 0.019
ENSG00000093009 E029 9.7009318 0.0017317685 8.993343e-02 1.750374e-01 22 19505054 19505361 308 + 1.119 0.946 -0.635
ENSG00000093009 E030 679.0442585 0.0001130406 4.379948e-01 5.798681e-01 22 19505362 19505412 51 + 2.826 2.818 -0.028
ENSG00000093009 E031 793.9203255 0.0001036736 7.466848e-02 1.510085e-01 22 19505413 19505481 69 + 2.901 2.879 -0.072
ENSG00000093009 E032 993.7952701 0.0003391359 3.138913e-01 4.565299e-01 22 19507386 19507517 132 + 2.975 2.987 0.041
ENSG00000093009 E033 796.1623509 0.0006075587 7.063237e-02 1.443951e-01 22 19507766 19507864 99 + 2.868 2.895 0.090
ENSG00000093009 E034 987.1707280 0.0001298712 2.528375e-08 2.889853e-07 22 19508530 19508691 162 + 2.934 3.005 0.237
ENSG00000093009 E035 862.0822743 0.0025880203 3.083153e-03 1.051077e-02 22 19514749 19514887 139 + 2.868 2.942 0.245
ENSG00000093009 E036 713.0792316 0.0020872256 1.737305e-03 6.399642e-03 22 19514965 19515048 84 + 2.785 2.862 0.256
ENSG00000093009 E037 15.8164996 0.0428610191 6.285466e-01 7.440827e-01 22 19516434 19516526 93 + 1.169 1.233 0.227
ENSG00000093009 E038 830.7445444 0.0014587206 1.089267e-06 8.969763e-06 22 19516527 19516645 119 + 2.831 2.938 0.354
ENSG00000093009 E039 4.9390315 0.0033724637 7.964443e-01 8.700746e-01 22 19516781 19516813 33 + 0.737 0.775 0.153
ENSG00000093009 E040 33.4193753 0.0006391841 7.516299e-02 1.517995e-01 22 19516814 19516816 3 + 1.443 1.559 0.397
ENSG00000093009 E041 634.5359837 0.0009074626 5.803110e-11 1.065499e-09 22 19516817 19516893 77 + 2.696 2.832 0.451
ENSG00000093009 E042 485.9332798 0.0011173031 3.832723e-12 8.542327e-11 22 19518844 19518909 66 + 2.560 2.725 0.548
ENSG00000093009 E043 307.7875941 0.0012993038 5.487442e-10 8.542148e-09 22 19520481 19520617 137 + 2.356 2.531 0.584