ENSG00000093000

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347635 ENSG00000093000 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP50 protein_coding protein_coding 29.93023 14.65884 48.12831 0.6065164 1.203806 1.714431 19.412064 11.0457526 30.921780 0.5529285 0.4008490 1.484293 0.65410000 0.75336667 0.6430667 -0.11030000 0.012455474 0.005667784 FALSE TRUE
MSTRG.22312.3 ENSG00000093000 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP50 protein_coding   29.93023 14.65884 48.12831 0.6065164 1.203806 1.714431 2.959643 0.5168613 5.458142 0.1457868 0.6552783 3.375556 0.08469167 0.03620000 0.1128667 0.07666667 0.005667784 0.005667784 FALSE TRUE
MSTRG.22312.5 ENSG00000093000 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP50 protein_coding   29.93023 14.65884 48.12831 0.6065164 1.203806 1.714431 2.895552 1.3652851 5.395372 0.3685362 0.8987736 1.974663 0.09377500 0.09493333 0.1115667 0.01663333 0.819249002 0.005667784 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000093000 E001 2.1820306 0.0072247187 5.027142e-01 6.387310e-01 22 45163925 45163985 61 + 0.427 0.585 0.769
ENSG00000093000 E002 2.6323105 0.0066753641 8.553811e-01 9.105791e-01 22 45163986 45163986 1 + 0.509 0.585 0.354
ENSG00000093000 E003 5.3271639 0.0031684676 7.945453e-01 8.687414e-01 22 45163987 45163996 10 + 0.737 0.826 0.354
ENSG00000093000 E004 5.7992137 0.0030183562 7.524899e-01 8.386641e-01 22 45163997 45163998 2 + 0.766 0.862 0.377
ENSG00000093000 E005 11.1965029 0.0020900083 3.023867e-02 7.243815e-02 22 45163999 45163999 1 + 1.091 0.894 -0.728
ENSG00000093000 E006 138.3049090 0.0117316175 3.324034e-04 1.510055e-03 22 45164000 45164281 282 + 2.139 1.970 -0.565
ENSG00000093000 E007 61.4002409 0.0165523639 2.764313e-03 9.565651e-03 22 45164282 45164296 15 + 1.793 1.605 -0.639
ENSG00000093000 E008 0.0000000       22 45164608 45164634 27 +      
ENSG00000093000 E009 0.0000000       22 45164635 45164645 11 +      
ENSG00000093000 E010 0.0000000       22 45164646 45164665 20 +      
ENSG00000093000 E011 0.0000000       22 45164666 45164679 14 +      
ENSG00000093000 E012 0.1472490 0.0440431433 1.000000e+00   22 45164680 45164728 49 + 0.074 0.000 -12.866
ENSG00000093000 E013 0.1472490 0.0440431433 1.000000e+00   22 45164729 45164758 30 + 0.074 0.000 -12.866
ENSG00000093000 E014 0.5106578 0.3438073365 2.395860e-01 3.736323e-01 22 45164759 45164955 197 + 0.074 0.332 2.628
ENSG00000093000 E015 0.7427016 0.0156952539 1.531848e-01 2.660055e-01 22 45165865 45166116 252 + 0.285 0.000 -15.254
ENSG00000093000 E016 11.7425199 0.0014557407 1.453210e-01 2.552937e-01 22 45166309 45166430 122 + 1.084 0.980 -0.382
ENSG00000093000 E017 0.2987644 0.0274967882 6.325407e-01   22 45168166 45168167 2 + 0.137 0.000 -13.920
ENSG00000093000 E018 61.4790928 0.0217050632 1.553535e-02 4.170328e-02 22 45168168 45168170 3 + 1.787 1.631 -0.531
ENSG00000093000 E019 146.1956485 0.0035961589 4.619782e-04 2.014232e-03 22 45168171 45168246 76 + 2.146 2.051 -0.316
ENSG00000093000 E020 19.2032535 0.0119835239 9.345882e-02 1.805246e-01 22 45170988 45171049 62 + 1.287 1.169 -0.417
ENSG00000093000 E021 24.8276201 0.0240718172 1.157881e-01 2.139311e-01 22 45171050 45171143 94 + 1.393 1.277 -0.405
ENSG00000093000 E022 13.7780461 0.0068590947 1.605092e-02 4.284867e-02 22 45171144 45171152 9 + 1.174 0.954 -0.799
ENSG00000093000 E023 2.3876725 0.0210964827 1.672988e-01 2.846799e-01 22 45171153 45171177 25 + 0.556 0.330 -1.190
ENSG00000093000 E024 180.4830941 0.0012525181 3.789324e-05 2.196885e-04 22 45171600 45171683 84 + 2.233 2.154 -0.266
ENSG00000093000 E025 5.9200382 0.0083598281 3.476363e-02 8.119271e-02 22 45171684 45171808 125 + 0.864 0.586 -1.147
ENSG00000093000 E026 8.4223662 0.1591662830 6.474209e-02 1.346226e-01 22 45171809 45172037 229 + 1.011 0.645 -1.437
ENSG00000093000 E027 6.6922528 0.0042772037 7.156420e-05 3.877595e-04 22 45172038 45172206 169 + 0.954 0.330 -2.809
ENSG00000093000 E028 3.3172632 0.0089110868 3.644203e-02 8.442475e-02 22 45175818 45175893 76 + 0.673 0.331 -1.704
ENSG00000093000 E029 249.9649101 0.0002338386 1.221420e-02 3.404561e-02 22 45175894 45176080 187 + 2.354 2.353 -0.002
ENSG00000093000 E030 9.4954094 0.0155093188 3.005094e-01 4.422069e-01 22 45177699 45178237 539 + 0.916 1.095 0.662
ENSG00000093000 E031 519.1780762 0.0001852623 9.145208e-06 6.133442e-05 22 45178238 45178799 562 + 2.675 2.660 -0.049
ENSG00000093000 E032 251.7346073 0.0002433036 4.301821e-02 9.657680e-02 22 45178800 45178900 101 + 2.353 2.365 0.040
ENSG00000093000 E033 1.8842983 0.0074323293 6.542967e-01 7.645050e-01 22 45180220 45180320 101 + 0.396 0.516 0.617
ENSG00000093000 E034 252.1398258 0.0002364946 8.582518e-01 9.125377e-01 22 45181286 45181367 82 + 2.336 2.403 0.224
ENSG00000093000 E035 258.2367303 0.0002476262 9.602707e-01 9.789877e-01 22 45183402 45183520 119 + 2.347 2.411 0.213
ENSG00000093000 E036 4.7511999 0.0034542504 1.942528e-03 7.048306e-03 22 45183521 45184452 932 + 0.533 1.005 1.917
ENSG00000093000 E037 2318.0700160 0.0067888859 3.216404e-04 1.467365e-03 22 45184453 45188177 3725 + 3.276 3.415 0.460