ENSG00000092978

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366934 ENSG00000092978 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH2 protein_coding protein_coding 4.91844 1.695002 7.553494 0.07692667 0.07580103 2.149279 1.53891744 0.6734800 2.4244053 0.06739770 0.14431472 1.832598 0.31404167 0.40106667 0.32080000 -0.08026667 0.52078063 0.01536771 FALSE TRUE
ENST00000366935 ENSG00000092978 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH2 protein_coding protein_coding 4.91844 1.695002 7.553494 0.07692667 0.07580103 2.149279 1.11474477 0.5954301 1.5132277 0.05121785 0.02556139 1.331099 0.27132917 0.35146667 0.20036667 -0.15110000 0.01536771 0.01536771 FALSE TRUE
ENST00000470014 ENSG00000092978 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH2 protein_coding processed_transcript 4.91844 1.695002 7.553494 0.07692667 0.07580103 2.149279 0.07428583 0.1561225 0.0000000 0.15612254 0.00000000 -4.054176 0.03235000 0.08453333 0.00000000 -0.08453333 0.51443376 0.01536771   FALSE
MSTRG.3055.2 ENSG00000092978 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH2 protein_coding   4.91844 1.695002 7.553494 0.07692667 0.07580103 2.149279 0.77797883 0.2699698 1.9384632 0.09192652 0.20996607 2.798994 0.15546667 0.16293333 0.25723333 0.09430000 0.44092655 0.01536771 TRUE TRUE
MSTRG.3055.3 ENSG00000092978 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH2 protein_coding   4.91844 1.695002 7.553494 0.07692667 0.07580103 2.149279 0.60211285 0.0000000 0.9824995 0.00000000 0.49327481 6.632994 0.09304167 0.00000000 0.12976667 0.12976667 0.38640536 0.01536771 FALSE TRUE
MSTRG.3055.5 ENSG00000092978 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH2 protein_coding   4.91844 1.695002 7.553494 0.07692667 0.07580103 2.149279 0.31252944 0.0000000 0.5893887 0.00000000 0.31476594 5.905420 0.04261250 0.00000000 0.07776667 0.07776667 0.43220066 0.01536771 FALSE TRUE
MSTRG.3055.7 ENSG00000092978 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH2 protein_coding   4.91844 1.695002 7.553494 0.07692667 0.07580103 2.149279 0.40925982 0.0000000 0.0000000 0.00000000 0.00000000 0.000000 0.06971667 0.00000000 0.00000000 0.00000000   0.01536771 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092978 E001 103.5103992 0.0005345021 6.924425e-09 8.791713e-08 1 217426992 217431042 4051 - 1.928 2.090 0.545
ENSG00000092978 E002 19.2876885 0.0016865386 1.628430e-01 2.788510e-01 1 217431043 217431119 77 - 1.238 1.324 0.301
ENSG00000092978 E003 27.4138566 0.0030898012 5.963451e-01 7.183145e-01 1 217431120 217431365 246 - 1.409 1.417 0.027
ENSG00000092978 E004 13.1514576 0.0014435093 8.280834e-01 8.919600e-01 1 217449249 217449337 89 - 1.112 1.105 -0.028
ENSG00000092978 E005 0.0000000       1 217491506 217491679 174 -      
ENSG00000092978 E006 11.6972770 0.0014448745 5.920348e-01 7.146676e-01 1 217491680 217491750 71 - 1.058 1.085 0.097
ENSG00000092978 E007 1.1781179 0.0117157276 9.505663e-01 9.730504e-01 1 217492501 217492525 25 - 0.330 0.325 -0.030
ENSG00000092978 E008 1.8822351 0.0379940650 4.892523e-01 6.267065e-01 1 217492526 217492693 168 - 0.401 0.509 0.555
ENSG00000092978 E009 2.6009887 0.0556994928 6.589198e-01 7.678847e-01 1 217495015 217495075 61 - 0.516 0.576 0.280
ENSG00000092978 E010 0.4439371 0.0215943238 4.655456e-01 6.052237e-01 1 217498180 217498355 176 - 0.196 0.000 -9.531
ENSG00000092978 E011 10.3866878 0.0016585895 9.254480e-01 9.570563e-01 1 217498356 217498395 40 - 1.036 0.997 -0.145
ENSG00000092978 E012 0.1472490 0.0427851377 1.000000e+00   1 217498396 217498764 369 - 0.075 0.000 -7.955
ENSG00000092978 E013 12.8452325 0.0016096825 6.456560e-01 7.577223e-01 1 217514822 217514889 68 - 1.106 1.123 0.061
ENSG00000092978 E014 73.6569880 0.0064516380 1.491027e-01 2.604591e-01 1 217608184 217610192 2009 - 1.821 1.869 0.162
ENSG00000092978 E015 24.5601823 0.0018826845 2.926617e-01 4.336364e-01 1 217610321 217610400 80 - 1.403 1.288 -0.400
ENSG00000092978 E016 38.8858541 0.0005683828 7.358309e-01 8.265039e-01 1 217610889 217611071 183 - 1.575 1.523 -0.178
ENSG00000092978 E017 26.7716871 0.0022041285 5.273580e-02 1.140185e-01 1 217614141 217614202 62 - 1.449 1.263 -0.648
ENSG00000092978 E018 110.4633275 0.0164124743 4.621408e-04 2.014802e-03 1 217619783 217620499 717 - 2.065 1.805 -0.875
ENSG00000092978 E019 28.2225056 0.0411257966 1.435684e-01 2.528691e-01 1 217630916 217631090 175 - 1.474 1.259 -0.747