ENSG00000092964

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311151 ENSG00000092964 HEK293_OSMI2_2hA HEK293_TMG_2hB DPYSL2 protein_coding protein_coding 5.720299 7.672171 4.71511 0.3647492 0.2429778 -0.701166 2.6736796 1.8264864 2.7027515 0.286498 0.4899319 0.5628087 0.5071542 0.2413333 0.5655667 0.3242333 0.01067483 0.01067483 FALSE TRUE
ENST00000521913 ENSG00000092964 HEK293_OSMI2_2hA HEK293_TMG_2hB DPYSL2 protein_coding protein_coding 5.720299 7.672171 4.71511 0.3647492 0.2429778 -0.701166 0.9795494 0.7018847 1.1037528 0.195128 0.2044341 0.6457137 0.1823375 0.0925000 0.2363000 0.1438000 0.09339384 0.01067483 FALSE TRUE
ENST00000523027 ENSG00000092964 HEK293_OSMI2_2hA HEK293_TMG_2hB DPYSL2 protein_coding protein_coding 5.720299 7.672171 4.71511 0.3647492 0.2429778 -0.701166 1.9587726 5.0506786 0.6425631 0.738695 0.3362044 -2.9551415 0.2889542 0.6538667 0.1419667 -0.5119000 0.12057053 0.01067483 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092964 E001 12.5920219 0.0279967906 1.518596e-02 4.090913e-02 8 26514031 26514679 649 + 1.213 1.036 -0.639
ENSG00000092964 E002 1.1458512 0.0110390162 9.110413e-02 1.768653e-01 8 26577062 26577367 306 + 0.439 0.206 -1.523
ENSG00000092964 E003 19.3189088 0.0088322480 4.539897e-03 1.465342e-02 8 26577843 26578293 451 + 1.368 1.235 -0.467
ENSG00000092964 E004 0.1515154 0.0430569175 3.272784e-01   8 26578405 26578533 129 + 0.130 0.000 -8.380
ENSG00000092964 E005 23.3431640 0.0062558797 1.420476e-03 5.374790e-03 8 26581969 26582057 89 + 1.445 1.312 -0.462
ENSG00000092964 E006 35.2553690 0.0072826183 1.629775e-03 6.056495e-03 8 26583799 26583983 185 + 1.603 1.503 -0.342
ENSG00000092964 E007 0.0000000       8 26619508 26620020 513 +      
ENSG00000092964 E008 0.0000000       8 26623849 26624142 294 +      
ENSG00000092964 E009 31.1402362 0.0006700657 2.934500e-06 2.200491e-05 8 26624143 26624307 165 + 1.588 1.423 -0.565
ENSG00000092964 E010 20.0973157 0.0013485029 5.670485e-07 4.965134e-06 8 26626617 26626678 62 + 1.445 1.184 -0.914
ENSG00000092964 E011 28.5114585 0.0008273680 2.214501e-10 3.678479e-09 8 26627215 26627295 81 + 1.607 1.323 -0.978
ENSG00000092964 E012 25.1848389 0.0007765773 4.999096e-11 9.293139e-10 8 26627872 26627940 69 + 1.572 1.248 -1.122
ENSG00000092964 E013 33.7472808 0.0007244217 5.565393e-05 3.099198e-04 8 26634780 26634900 121 + 1.599 1.483 -0.397
ENSG00000092964 E014 0.0000000       8 26637530 26638011 482 +      
ENSG00000092964 E015 0.4386386 0.1267518445 3.792586e-01 5.235272e-01 8 26642826 26643145 320 + 0.230 0.114 -1.211
ENSG00000092964 E016 43.1809458 0.0011111009 6.622356e-04 2.760364e-03 8 26643439 26643595 157 + 1.676 1.616 -0.203
ENSG00000092964 E017 39.1759558 0.0005527780 2.288663e-03 8.115532e-03 8 26643950 26644091 142 + 1.625 1.580 -0.154
ENSG00000092964 E018 39.6344566 0.0008834072 7.259281e-06 4.978817e-05 8 26647630 26647800 171 + 1.670 1.544 -0.428
ENSG00000092964 E019 37.8082748 0.0006704361 1.143152e-06 9.375183e-06 8 26652257 26652436 180 + 1.660 1.509 -0.515
ENSG00000092964 E020 34.8523957 0.0006277074 2.533842e-04 1.189338e-03 8 26653232 26653397 166 + 1.599 1.509 -0.310
ENSG00000092964 E021 559.7966266 0.0040974403 6.367133e-37 1.800350e-34 8 26655615 26658178 2564 + 2.497 2.861 1.214