ENSG00000092853

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251195 ENSG00000092853 HEK293_OSMI2_2hA HEK293_TMG_2hB CLSPN protein_coding protein_coding 15.02322 6.893232 22.46307 0.8695132 0.1476513 1.702854 2.553586 1.84042080 3.322013 0.22110902 0.1753336 0.8485406 0.19851250 0.267700000 0.1478000 -0.119900000 1.839121e-04 1.206798e-11 FALSE TRUE
ENST00000318121 ENSG00000092853 HEK293_OSMI2_2hA HEK293_TMG_2hB CLSPN protein_coding protein_coding 15.02322 6.893232 22.46307 0.8695132 0.1476513 1.702854 3.903285 3.05230877 4.839407 0.29863050 0.1296604 0.6631886 0.29997917 0.450266667 0.2154000 -0.234866667 1.848334e-04 1.206798e-11 FALSE TRUE
ENST00000520551 ENSG00000092853 HEK293_OSMI2_2hA HEK293_TMG_2hB CLSPN protein_coding protein_coding 15.02322 6.893232 22.46307 0.8695132 0.1476513 1.702854 1.507760 0.05575985 3.009319 0.03159895 0.5690257 5.5208724 0.07659583 0.009133333 0.1338333 0.124700000 5.663660e-07 1.206798e-11 FALSE TRUE
MSTRG.831.2 ENSG00000092853 HEK293_OSMI2_2hA HEK293_TMG_2hB CLSPN protein_coding   15.02322 6.893232 22.46307 0.8695132 0.1476513 1.702854 1.595933 0.75791544 2.348894 0.14490486 0.1718276 1.6190915 0.11003750 0.110000000 0.1046333 -0.005366667 9.869966e-01 1.206798e-11 FALSE TRUE
MSTRG.831.4 ENSG00000092853 HEK293_OSMI2_2hA HEK293_TMG_2hB CLSPN protein_coding   15.02322 6.893232 22.46307 0.8695132 0.1476513 1.702854 2.691679 0.01815966 4.364406 0.01815966 0.6851341 7.2793133 0.14452083 0.003166667 0.1946667 0.191500000 1.206798e-11 1.206798e-11 TRUE TRUE
MSTRG.831.7 ENSG00000092853 HEK293_OSMI2_2hA HEK293_TMG_2hB CLSPN protein_coding   15.02322 6.893232 22.46307 0.8695132 0.1476513 1.702854 0.963331 0.33570404 2.266437 0.13867036 0.6121491 2.7191679 0.05364167 0.045500000 0.1006667 0.055166667 2.913202e-01 1.206798e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092853 E001 33.6700681 0.0007137858 8.528244e-08 8.773079e-07 1 35720218 35720470 253 - 1.369 1.720 1.202
ENSG00000092853 E002 6.2634786 0.0026570578 7.222807e-05 3.909875e-04 1 35720471 35720671 201 - 0.605 1.117 1.998
ENSG00000092853 E003 2.9796952 0.0051538146 5.348351e-03 1.687927e-02 1 35720672 35720683 12 - 0.382 0.831 2.034
ENSG00000092853 E004 5.9196613 0.0056848918 1.340129e-05 8.643427e-05 1 35720684 35720737 54 - 0.534 1.117 2.321
ENSG00000092853 E005 74.7320732 0.0084517119 4.413747e-06 3.180446e-05 1 35720738 35720977 240 - 1.724 2.026 1.017
ENSG00000092853 E006 17.7955261 0.0014537145 1.248433e-05 8.113616e-05 1 35720978 35720980 3 - 1.075 1.460 1.356
ENSG00000092853 E007 3.1207033 0.0056087691 9.623576e-02 1.847264e-01 1 35723620 35723685 66 - 0.479 0.758 1.231
ENSG00000092853 E008 417.8312063 0.0113106787 5.696123e-09 7.360937e-08 1 35732112 35736246 4135 - 2.464 2.782 1.058
ENSG00000092853 E009 37.5810370 0.0005716739 5.470667e-01 6.771520e-01 1 35736247 35736280 34 - 1.532 1.595 0.214
ENSG00000092853 E010 66.5069862 0.0011914582 5.727814e-01 6.988462e-01 1 35736281 35736404 124 - 1.797 1.796 -0.004
ENSG00000092853 E011 59.1407096 0.0003947132 1.355783e-01 2.419157e-01 1 35736405 35736484 80 - 1.764 1.716 -0.163
ENSG00000092853 E012 81.2186697 0.0007353807 5.109576e-01 6.460936e-01 1 35736485 35736606 122 - 1.867 1.921 0.184
ENSG00000092853 E013 142.2770923 0.0017977263 3.915745e-04 1.742317e-03 1 35736914 35737075 162 - 2.067 2.222 0.519
ENSG00000092853 E014 102.3119718 0.0003499862 7.073950e-06 4.865800e-05 1 35737339 35737421 83 - 1.912 2.102 0.639
ENSG00000092853 E015 1.5177822 0.0086217744 1.479403e-01 2.588750e-01 1 35737698 35737991 294 - 0.449 0.184 -1.787
ENSG00000092853 E016 125.6838801 0.0017872861 3.814320e-03 1.262134e-02 1 35737992 35738097 106 - 2.023 2.160 0.458
ENSG00000092853 E017 120.1074830 0.0002639121 1.995123e-01 3.256257e-01 1 35738455 35738582 128 - 2.028 2.099 0.237
ENSG00000092853 E018 137.5705270 0.0019350642 1.411584e-01 2.496246e-01 1 35739136 35739257 122 - 2.080 2.164 0.280
ENSG00000092853 E019 199.0694500 0.0001869224 5.684305e-04 2.415546e-03 1 35739365 35739529 165 - 2.228 2.346 0.392
ENSG00000092853 E020 140.9445956 0.0003079381 9.286173e-02 1.796057e-01 1 35743141 35743241 101 - 2.095 2.175 0.269
ENSG00000092853 E021 106.0798729 0.0002611814 9.310287e-01 9.605687e-01 1 35743455 35743530 76 - 1.991 2.015 0.079
ENSG00000092853 E022 110.4239058 0.0002546807 1.828269e-02 4.774879e-02 1 35745451 35745562 112 - 2.034 1.973 -0.203
ENSG00000092853 E023 145.2679069 0.0026928495 4.032841e-02 9.163370e-02 1 35746766 35746964 199 - 2.150 2.096 -0.182
ENSG00000092853 E024 63.0215622 0.0045335606 5.513199e-01 6.808078e-01 1 35746965 35746992 28 - 1.777 1.770 -0.022
ENSG00000092853 E025 117.1504183 0.0040087716 1.550842e-02 4.164655e-02 1 35747907 35748061 155 - 2.066 1.981 -0.284
ENSG00000092853 E026 121.2238608 0.0014485510 5.601143e-03 1.755629e-02 1 35748405 35748604 200 - 2.080 1.997 -0.277
ENSG00000092853 E027 0.6685028 0.0179032840 3.820690e-01 5.263180e-01 1 35748605 35748774 170 - 0.147 0.312 1.382
ENSG00000092853 E028 64.8219110 0.0003597028 2.462493e-02 6.110656e-02 1 35749467 35749531 65 - 1.811 1.729 -0.278
ENSG00000092853 E029 49.3399738 0.0004305280 3.438216e-01 4.878734e-01 1 35749633 35749652 20 - 1.679 1.654 -0.084
ENSG00000092853 E030 93.1315152 0.0003884853 9.719463e-01 9.864636e-01 1 35749653 35749811 159 - 1.933 1.958 0.086
ENSG00000092853 E031 142.3277446 0.0003341361 2.013020e-01 3.278181e-01 1 35751250 35751506 257 - 2.128 2.113 -0.049
ENSG00000092853 E032 123.5412908 0.0002355059 3.240613e-03 1.097391e-02 1 35753745 35753936 192 - 2.087 2.010 -0.257
ENSG00000092853 E033 254.5115483 0.0002344570 3.654888e-12 8.170964e-11 1 35760342 35760916 575 - 2.419 2.270 -0.496
ENSG00000092853 E034 76.5598030 0.0003510017 6.483728e-07 5.606988e-06 1 35761096 35761204 109 - 1.913 1.707 -0.696
ENSG00000092853 E035 58.8845461 0.0012584201 4.433812e-05 2.529961e-04 1 35761998 35762070 73 - 1.799 1.601 -0.670
ENSG00000092853 E036 70.2882144 0.0014846586 1.614466e-07 1.576007e-06 1 35762404 35762481 78 - 1.887 1.639 -0.837
ENSG00000092853 E037 100.3250174 0.0040635314 1.566341e-06 1.246696e-05 1 35763160 35763321 162 - 2.032 1.812 -0.740
ENSG00000092853 E038 192.5478285 0.0029599917 1.026990e-13 2.915634e-12 1 35764266 35764714 449 - 2.323 2.054 -0.900
ENSG00000092853 E039 85.3067427 0.0106256174 7.456718e-07 6.366742e-06 1 35765218 35765326 109 - 1.979 1.669 -1.047
ENSG00000092853 E040 62.3548996 0.0064149608 8.998979e-06 6.046567e-05 1 35769847 35769998 152 - 1.837 1.573 -0.895