ENSG00000092470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263795 ENSG00000092470 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR76 protein_coding protein_coding 11.01097 6.971882 13.62993 0.4638871 0.3557932 0.9661487 1.5344901 0.84734430 1.6188288 0.44066414 0.2977933 0.9258884 0.14612917 0.114700000 0.11846667 0.003766667 9.156988e-01 9.354135e-35 FALSE TRUE
ENST00000381246 ENSG00000092470 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR76 protein_coding protein_coding 11.01097 6.971882 13.62993 0.4638871 0.3557932 0.9661487 3.0543068 2.27996233 2.9221203 0.24470883 0.2754183 0.3566204 0.27487083 0.331633333 0.21373333 -0.117900000 1.708552e-01 9.354135e-35 FALSE TRUE
ENST00000452115 ENSG00000092470 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR76 protein_coding protein_coding 11.01097 6.971882 13.62993 0.4638871 0.3557932 0.9661487 0.4274395 0.00000000 1.7113145 0.00000000 0.4744996 7.4273669 0.02880000 0.000000000 0.12396667 0.123966667 4.401240e-08 9.354135e-35 FALSE FALSE
MSTRG.10703.1 ENSG00000092470 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR76 protein_coding   11.01097 6.971882 13.62993 0.4638871 0.3557932 0.9661487 1.3437165 2.14232073 1.0854042 0.56518150 0.5432968 -0.9744298 0.14454167 0.300966667 0.08123333 -0.219733333 3.725067e-01 9.354135e-35 FALSE TRUE
MSTRG.10703.10 ENSG00000092470 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR76 protein_coding   11.01097 6.971882 13.62993 0.4638871 0.3557932 0.9661487 3.0299362 0.00000000 4.8047688 0.00000000 0.1466333 8.9113227 0.22445000 0.000000000 0.35346667 0.353466667 9.354135e-35 9.354135e-35 FALSE TRUE
MSTRG.10703.5 ENSG00000092470 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR76 protein_coding   11.01097 6.971882 13.62993 0.4638871 0.3557932 0.9661487 0.7841095 0.04299517 0.7348266 0.04299517 0.2670618 3.8129718 0.07671667 0.005433333 0.05446667 0.049033333 9.911888e-02 9.354135e-35 TRUE TRUE
MSTRG.10703.8 ENSG00000092470 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR76 protein_coding   11.01097 6.971882 13.62993 0.4638871 0.3557932 0.9661487 0.3328358 1.23990568 0.4903403 0.37042996 0.2491444 -1.3208376 0.03948750 0.184466667 0.03606667 -0.148400000 2.551833e-01 9.354135e-35 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092470 E001 0.9619567 0.2786855457 3.462989e-01 4.904394e-01 15 43824844 43824905 62 + 0.375 0.144 -1.804
ENSG00000092470 E002 1.5135132 0.0088216030 8.633010e-01 9.158237e-01 15 43826913 43826979 67 + 0.375 0.406 0.171
ENSG00000092470 E003 1.5135132 0.0088216030 8.633010e-01 9.158237e-01 15 43826980 43826984 5 + 0.375 0.406 0.171
ENSG00000092470 E004 1.8069791 0.0081333665 7.993059e-01 8.719939e-01 15 43826985 43826986 2 + 0.423 0.467 0.229
ENSG00000092470 E005 1.8069791 0.0081333665 7.993059e-01 8.719939e-01 15 43826987 43826987 1 + 0.423 0.467 0.229
ENSG00000092470 E006 2.3875667 0.0067075987 2.476053e-01 3.831326e-01 15 43826988 43826991 4 + 0.423 0.612 0.908
ENSG00000092470 E007 3.6753683 0.0047965896 4.320206e-01 5.744839e-01 15 43826992 43827001 10 + 0.604 0.720 0.493
ENSG00000092470 E008 5.0405012 0.0032889904 4.533765e-01 5.941040e-01 15 43827002 43827010 9 + 0.732 0.832 0.398
ENSG00000092470 E009 9.5192169 0.0018054923 7.969045e-01 8.704067e-01 15 43827011 43827025 15 + 1.014 1.042 0.103
ENSG00000092470 E010 27.4596036 0.0007362438 2.039592e-02 5.231801e-02 15 43827026 43827092 67 + 1.516 1.362 -0.534
ENSG00000092470 E011 2.5076480 0.0066259707 8.693589e-01 9.200203e-01 15 43827093 43827118 26 + 0.540 0.568 0.127
ENSG00000092470 E012 43.5154143 0.0005493597 1.741030e-03 6.411745e-03 15 43827965 43828074 110 + 1.716 1.548 -0.572
ENSG00000092470 E013 55.7816866 0.0004163674 2.357538e-03 8.331223e-03 15 43828075 43828176 102 + 1.814 1.671 -0.484
ENSG00000092470 E014 80.5815147 0.0048809131 7.156994e-03 2.163060e-02 15 43828177 43828366 190 + 1.970 1.832 -0.462
ENSG00000092470 E015 64.6703048 0.0003948254 1.607912e-05 1.019083e-04 15 43835061 43835150 90 + 1.896 1.706 -0.643
ENSG00000092470 E016 50.4635201 0.0004767322 6.178499e-06 4.309322e-05 15 43836161 43836216 56 + 1.803 1.576 -0.772
ENSG00000092470 E017 84.1841762 0.0003393087 7.921814e-06 5.385645e-05 15 43839605 43839728 124 + 2.003 1.831 -0.578
ENSG00000092470 E018 81.0973746 0.0004734470 1.345522e-01 2.404788e-01 15 43842415 43842516 102 + 1.942 1.884 -0.194
ENSG00000092470 E019 57.6779702 0.0038103899 8.432022e-01 9.023475e-01 15 43842628 43842671 44 + 1.774 1.761 -0.043
ENSG00000092470 E020 93.5419010 0.0003651569 3.199608e-01 4.630469e-01 15 43843901 43844054 154 + 1.993 1.958 -0.117
ENSG00000092470 E021 97.6964454 0.0007485325 7.058691e-02 1.443177e-01 15 43851087 43851245 159 + 2.022 1.957 -0.221
ENSG00000092470 E022 95.1713016 0.0015611478 1.458515e-01 2.560191e-01 15 43856946 43857163 218 + 1.958 2.016 0.195
ENSG00000092470 E023 0.2987644 0.0293092344 3.136782e-01   15 43858507 43858580 74 + 0.190 0.000 -10.933
ENSG00000092470 E024 97.6737794 0.0003013349 4.636076e-02 1.026910e-01 15 43858671 43858823 153 + 1.960 2.031 0.237
ENSG00000092470 E025 75.7262652 0.0003445105 2.488470e-01 3.845829e-01 15 43861333 43861386 54 + 1.863 1.910 0.158
ENSG00000092470 E026 117.0071784 0.0004767094 5.850479e-03 1.821995e-02 15 43866128 43866325 198 + 2.026 2.116 0.302
ENSG00000092470 E027 36.9189850 0.0007584055 3.807352e-03 1.260074e-02 15 43866326 43866342 17 + 1.490 1.657 0.569
ENSG00000092470 E028 98.2236098 0.0005568151 1.873871e-10 3.154427e-09 15 43866343 43866671 329 + 1.880 2.109 0.767
ENSG00000092470 E029 81.7562798 0.0031101234 1.601444e-07 1.564263e-06 15 43866672 43867180 509 + 1.794 2.036 0.815
ENSG00000092470 E030 27.6078145 0.0058225220 6.567691e-01 7.662549e-01 15 43867181 43867476 296 + 1.474 1.440 -0.116
ENSG00000092470 E031 5.0689966 0.0061401892 5.374825e-01 6.690438e-01 15 43867477 43867588 112 + 0.830 0.750 -0.319
ENSG00000092470 E032 44.9568258 0.0007458263 1.121589e-04 5.777411e-04 15 43867589 43868412 824 + 1.561 1.764 0.688
ENSG00000092470 E033 0.0000000       15 43876960 43877017 58 +      
ENSG00000092470 E034 0.6330284 0.0517326216 7.457057e-01 8.336724e-01 15 43881938 43882010 73 + 0.190 0.248 0.487
ENSG00000092470 E035 1.6607648 0.0083042739 1.730297e-02 4.560818e-02 15 43890286 43890392 107 + 0.573 0.142 -2.831
ENSG00000092470 E036 0.8899506 0.0134475402 2.237459e-02 5.645654e-02 15 43890630 43890679 50 + 0.423 0.000 -12.517