ENSG00000092445

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263798 ENSG00000092445 HEK293_OSMI2_2hA HEK293_TMG_2hB TYRO3 protein_coding protein_coding 14.00802 19.25486 11.84732 1.556127 0.1726966 -0.7001935 4.330634 7.250434 2.719096 0.1289774 0.1297598 -1.4116325 0.2998083 0.3817667 0.2299333 -0.1518333 0.007719851 0.007719851 FALSE TRUE
MSTRG.10608.5 ENSG00000092445 HEK293_OSMI2_2hA HEK293_TMG_2hB TYRO3 protein_coding   14.00802 19.25486 11.84732 1.556127 0.1726966 -0.7001935 8.737134 10.752217 8.290320 1.3959935 0.4163933 -0.3747363 0.6345042 0.5536333 0.6990667 0.1454333 0.033467583 0.007719851 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092445 E001 0.0000000       15 41557675 41558472 798 +      
ENSG00000092445 E002 1.3275556 0.0101932612 7.642848e-02 1.537897e-01 15 41559182 41559211 30 + 0.521 0.227 -1.755
ENSG00000092445 E003 2.5443832 0.0067438064 4.536440e-04 1.981177e-03 15 41559212 41559226 15 + 0.817 0.282 -2.604
ENSG00000092445 E004 3.3215402 0.0129688784 5.578674e-05 3.105819e-04 15 41559227 41559230 4 + 0.925 0.331 -2.696
ENSG00000092445 E005 36.9534763 0.0037532463 1.858700e-05 1.161817e-04 15 41559231 41559381 151 + 1.696 1.451 -0.837
ENSG00000092445 E006 120.6803837 0.0087194597 4.446432e-03 1.438953e-02 15 41561127 41561310 184 + 2.128 2.002 -0.424
ENSG00000092445 E007 1.7110250 0.2550176611 2.500929e-01 3.860266e-01 15 41561311 41561538 228 + 0.579 0.324 -1.329
ENSG00000092445 E008 118.2706464 0.0038566432 4.362055e-04 1.913533e-03 15 41561539 41561639 101 + 2.119 1.994 -0.421
ENSG00000092445 E009 13.3792820 0.0047260648 5.841726e-01 7.081640e-01 15 41561640 41562355 716 + 1.049 1.133 0.305
ENSG00000092445 E010 144.6019234 0.0044052881 7.152065e-01 8.111897e-01 15 41562548 41562718 171 + 2.110 2.124 0.047
ENSG00000092445 E011 114.7637806 0.0029011323 8.266729e-01 8.909269e-01 15 41564184 41564270 87 + 2.003 2.024 0.071
ENSG00000092445 E012 0.9996463 0.0132164424 3.545655e-01 4.988808e-01 15 41564784 41565025 242 + 0.378 0.227 -1.019
ENSG00000092445 E013 125.8958748 0.0046543400 5.642652e-01 6.915778e-01 15 41565026 41565141 116 + 2.056 2.060 0.016
ENSG00000092445 E014 55.7622239 0.0010126098 5.024645e-01 6.385232e-01 15 41567360 41567368 9 + 1.716 1.710 -0.019
ENSG00000092445 E015 58.4966000 0.0004977369 4.388547e-01 5.806848e-01 15 41567369 41567378 10 + 1.738 1.729 -0.032
ENSG00000092445 E016 144.6253920 0.0003083280 6.772631e-01 7.820214e-01 15 41567379 41567537 159 + 2.086 2.129 0.143
ENSG00000092445 E017 159.6917935 0.0002505772 2.569933e-01 3.940258e-01 15 41568217 41568362 146 + 2.164 2.159 -0.017
ENSG00000092445 E018 151.7401937 0.0003516349 8.511233e-03 2.506572e-02 15 41568878 41569022 145 + 2.174 2.122 -0.175
ENSG00000092445 E019 148.2136724 0.0002772974 2.289763e-01 3.612186e-01 15 41570027 41570156 130 + 2.134 2.126 -0.029
ENSG00000092445 E020 149.2562353 0.0002356022 1.462851e-01 2.566305e-01 15 41570240 41570340 101 + 2.143 2.127 -0.053
ENSG00000092445 E021 140.2608145 0.0002266643 9.912125e-02 1.891364e-01 15 41570604 41570676 73 + 2.121 2.097 -0.079
ENSG00000092445 E022 94.1307870 0.0003445628 8.490581e-01 9.063180e-01 15 41570677 41570699 23 + 1.917 1.938 0.072
ENSG00000092445 E023 0.0000000       15 41570938 41571037 100 +      
ENSG00000092445 E024 111.6339689 0.0015343761 5.138606e-01 6.486330e-01 15 41571038 41571102 65 + 2.003 2.006 0.012
ENSG00000092445 E025 64.5124228 0.0017906376 9.264943e-01 9.577150e-01 15 41571103 41571118 16 + 1.749 1.783 0.115
ENSG00000092445 E026 0.5901394 0.3013338005 9.429528e-01 9.682206e-01 15 41571549 41571594 46 + 0.165 0.169 0.035
ENSG00000092445 E027 123.1892115 0.0004960187 8.098037e-01 8.792843e-01 15 41571595 41571687 93 + 2.034 2.054 0.070
ENSG00000092445 E028 149.9297161 0.0002699697 7.042057e-01 8.028015e-01 15 41572443 41572564 122 + 2.121 2.138 0.058
ENSG00000092445 E029 89.7388125 0.0003398950 4.342047e-02 9.733385e-02 15 41573002 41573016 15 + 1.952 1.901 -0.171
ENSG00000092445 E030 144.7471731 0.0002395095 1.023634e-02 2.934723e-02 15 41573017 41573111 95 + 2.156 2.105 -0.170
ENSG00000092445 E031 199.0155388 0.0002801896 5.304401e-02 1.145593e-01 15 41573308 41573467 160 + 2.272 2.249 -0.077
ENSG00000092445 E032 194.7164046 0.0011141693 7.241173e-01 8.177411e-01 15 41573679 41573813 135 + 2.216 2.257 0.137
ENSG00000092445 E033 76.4097886 0.0037801596 8.639949e-02 1.696407e-01 15 41573814 41573815 2 + 1.749 1.872 0.416
ENSG00000092445 E034 3.3807591 0.0094811039 5.703101e-03 1.782496e-02 15 41573816 41573853 38 + 0.847 0.452 -1.719
ENSG00000092445 E035 3.5248945 0.0147859771 5.305914e-01 6.631964e-01 15 41574656 41574712 57 + 0.521 0.647 0.570
ENSG00000092445 E036 12.5467037 0.0015956648 1.615997e-01 2.771892e-01 15 41577335 41577885 551 + 0.948 1.126 0.649
ENSG00000092445 E037 850.7964977 0.0055313808 8.542174e-08 8.785501e-07 15 41577886 41583589 5704 + 2.732 2.938 0.685