ENSG00000092421

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343348 ENSG00000092421 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA6A protein_coding protein_coding 5.964199 5.057128 5.452452 0.3630627 0.3427708 0.1083806 4.3300486 4.5391354 3.3822538 0.25984778 0.11058789 -0.4233483 0.74266667 0.90053333 0.62286667 -0.2776667 9.072464e-03 4.530609e-16 FALSE TRUE
ENST00000510263 ENSG00000092421 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA6A protein_coding protein_coding 5.964199 5.057128 5.452452 0.3630627 0.3427708 0.1083806 0.6072629 0.0000000 1.2431134 0.00000000 0.09168842 6.9693732 0.09726667 0.00000000 0.23046667 0.2304667 4.530609e-16 4.530609e-16 FALSE TRUE
ENST00000513137 ENSG00000092421 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA6A protein_coding protein_coding 5.964199 5.057128 5.452452 0.3630627 0.3427708 0.1083806 0.4229024 0.1432889 0.3712996 0.03178079 0.05514241 1.3146717 0.06862500 0.02773333 0.06793333 0.0402000 7.019899e-02 4.530609e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092421 E001 287.0428742 0.0088694023 7.695113e-15 2.575192e-13 5 116443555 116445749 2195 - 2.213 2.591 1.261
ENSG00000092421 E002 68.5377789 0.0004505886 1.673187e-15 6.143029e-14 5 116445750 116446133 384 - 1.579 1.977 1.348
ENSG00000092421 E003 68.5576886 0.0017978870 3.744560e-04 1.675316e-03 5 116446134 116446463 330 - 1.717 1.921 0.689
ENSG00000092421 E004 51.9178914 0.0035355418 3.294236e-01 4.729372e-01 5 116446464 116446612 149 - 1.666 1.759 0.315
ENSG00000092421 E005 143.3217082 0.0002729498 4.180820e-01 5.613711e-01 5 116446613 116447687 1075 - 2.119 2.182 0.210
ENSG00000092421 E006 33.7988170 0.0006343113 6.782590e-01 7.827801e-01 5 116447688 116447811 124 - 1.497 1.561 0.217
ENSG00000092421 E007 0.3666179 0.0320157296 9.544836e-01 9.754649e-01 5 116449317 116449646 330 - 0.122 0.123 0.019
ENSG00000092421 E008 46.8246338 0.0005467281 3.727037e-02 8.598446e-02 5 116467583 116467747 165 - 1.709 1.642 -0.227
ENSG00000092421 E009 13.7092536 0.0012876526 1.380204e-04 6.948223e-04 5 116467748 116469544 1797 - 1.303 0.993 -1.112
ENSG00000092421 E010 0.8147197 0.0164202331 7.237396e-01 8.174855e-01 5 116472885 116472935 51 - 0.217 0.297 0.599
ENSG00000092421 E011 26.1297863 0.0007577458 5.614380e-03 1.758934e-02 5 116473073 116473093 21 - 1.502 1.354 -0.510
ENSG00000092421 E012 34.6350335 0.0027531885 5.868325e-03 1.826598e-02 5 116475545 116475603 59 - 1.614 1.479 -0.461
ENSG00000092421 E013 29.7494265 0.0007368881 1.368636e-01 2.437131e-01 5 116477846 116477926 81 - 1.511 1.455 -0.191
ENSG00000092421 E014 41.6479226 0.0014684658 7.963832e-03 2.368558e-02 5 116478014 116478154 141 - 1.681 1.572 -0.369
ENSG00000092421 E015 0.0000000       5 116478266 116478541 276 -      
ENSG00000092421 E016 49.5727046 0.0005163121 5.120477e-07 4.520101e-06 5 116478542 116478718 177 - 1.800 1.591 -0.711
ENSG00000092421 E017 45.6604076 0.0005677002 1.824341e-04 8.883586e-04 5 116480122 116480277 156 - 1.743 1.591 -0.519
ENSG00000092421 E018 0.0000000       5 116480278 116480279 2 -      
ENSG00000092421 E019 21.5268258 0.0010812589 1.621139e-01 2.778787e-01 5 116482444 116482458 15 - 1.386 1.321 -0.224
ENSG00000092421 E020 38.7766019 0.0006793646 7.662588e-03 2.293365e-02 5 116482459 116482575 117 - 1.650 1.540 -0.374
ENSG00000092421 E021 0.4448795 0.6017285490 2.946305e-01 4.357424e-01 5 116486641 116486748 108 - 0.000 0.283 11.083
ENSG00000092421 E022 49.2095514 0.0005147548 4.127460e-03 1.349862e-02 5 116486749 116486966 218 - 1.748 1.645 -0.349
ENSG00000092421 E023 0.1817044 0.0394711022 5.235313e-01   5 116486967 116487229 263 - 0.000 0.123 11.245
ENSG00000092421 E024 31.9857308 0.0187232217 3.366895e-01 4.805570e-01 5 116488108 116488196 89 - 1.540 1.488 -0.179
ENSG00000092421 E025 25.3397412 0.0185782669 1.072928e-01 2.015376e-01 5 116488888 116488914 27 - 1.475 1.358 -0.404
ENSG00000092421 E026 37.7546483 0.0024174145 4.793903e-04 2.081049e-03 5 116488915 116489007 93 - 1.669 1.498 -0.584
ENSG00000092421 E027 0.0000000       5 116489008 116489009 2 -      
ENSG00000092421 E028 26.5208747 0.0083110488 5.540153e-02 1.186768e-01 5 116491740 116491795 56 - 1.488 1.376 -0.388
ENSG00000092421 E029 24.3409841 0.0008143885 1.953389e-01 3.203848e-01 5 116491796 116491830 35 - 1.424 1.373 -0.179
ENSG00000092421 E030 0.1817044 0.0394711022 5.235313e-01   5 116492327 116492485 159 - 0.000 0.123 11.245
ENSG00000092421 E031 29.6838721 0.0218921710 4.876583e-01 6.253031e-01 5 116495413 116495514 102 - 1.493 1.474 -0.064
ENSG00000092421 E032 24.5099918 0.0168951316 6.144338e-01 7.329172e-01 5 116496251 116496313 63 - 1.403 1.404 0.004
ENSG00000092421 E033 26.9900087 0.0053544797 5.404972e-02 1.163467e-01 5 116497327 116497387 61 - 1.493 1.392 -0.348
ENSG00000092421 E034 36.3857038 0.0385319261 2.639647e-02 6.473942e-02 5 116502210 116502327 118 - 1.659 1.471 -0.643
ENSG00000092421 E035 0.0000000       5 116502439 116502677 239 -      
ENSG00000092421 E036 32.9617982 0.0189454666 1.683795e-04 8.282658e-04 5 116504845 116504982 138 - 1.659 1.367 -1.003
ENSG00000092421 E037 0.0000000       5 116536298 116536382 85 -      
ENSG00000092421 E038 0.0000000       5 116536383 116536458 76 -      
ENSG00000092421 E039 0.3634088 0.3204608290 3.028817e-01   5 116550115 116550646 532 - 0.000 0.220 11.282
ENSG00000092421 E040 0.0000000       5 116554739 116554896 158 -      
ENSG00000092421 E041 35.8167787 0.0267754179 1.010396e-04 5.267107e-04 5 116574185 116574823 639 - 1.711 1.382 -1.125