ENSG00000092208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000250379 ENSG00000092208 HEK293_OSMI2_2hA HEK293_TMG_2hB GEMIN2 protein_coding protein_coding 28.27846 15.37735 45.70621 3.195453 1.298804 1.570962 3.839180 1.484549 7.774827 0.4533061 0.3945654 2.380955 0.12269583 0.09360000 0.17063333 0.077033333 8.605482e-02 3.761226e-11 FALSE TRUE
ENST00000308317 ENSG00000092208 HEK293_OSMI2_2hA HEK293_TMG_2hB GEMIN2 protein_coding protein_coding 28.27846 15.37735 45.70621 3.195453 1.298804 1.570962 15.853916 10.190964 21.754944 1.3781723 0.6660998 1.093301 0.59677500 0.68220000 0.47606667 -0.206133333 2.658403e-02 3.761226e-11 FALSE TRUE
ENST00000412033 ENSG00000092208 HEK293_OSMI2_2hA HEK293_TMG_2hB GEMIN2 protein_coding nonsense_mediated_decay 28.27846 15.37735 45.70621 3.195453 1.298804 1.570962 1.625515 1.100919 3.346177 0.3307890 0.5190004 1.595065 0.05951667 0.07033333 0.07320000 0.002866667 1.000000e+00 3.761226e-11 FALSE TRUE
ENST00000534684 ENSG00000092208 HEK293_OSMI2_2hA HEK293_TMG_2hB GEMIN2 protein_coding protein_coding 28.27846 15.37735 45.70621 3.195453 1.298804 1.570962 1.688329 0.000000 3.063562 0.0000000 0.5948667 8.263768 0.03868333 0.00000000 0.06743333 0.067433333 3.761226e-11 3.761226e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092208 E001 1.6682655 0.1438217634 5.340616e-01 6.661806e-01 14 39114267 39114284 18 + 0.459 0.304 -0.890
ENSG00000092208 E002 8.5846864 0.0022186999 4.491071e-01 5.903077e-01 14 39114285 39114305 21 + 0.939 1.028 0.328
ENSG00000092208 E003 14.9892181 0.0063286208 7.121526e-01 8.089819e-01 14 39114306 39114316 11 + 1.198 1.167 -0.109
ENSG00000092208 E004 16.1801232 0.0018904110 4.071894e-01 5.507855e-01 14 39114317 39114319 3 + 1.241 1.168 -0.259
ENSG00000092208 E005 17.8398559 0.0010976593 3.005233e-01 4.422208e-01 14 39114320 39114322 3 + 1.286 1.197 -0.311
ENSG00000092208 E006 17.9871049 0.0011590502 2.755114e-01 4.148306e-01 14 39114323 39114323 1 + 1.290 1.197 -0.328
ENSG00000092208 E007 24.7655502 0.0041217724 6.214425e-01 7.384128e-01 14 39114324 39114330 7 + 1.404 1.368 -0.124
ENSG00000092208 E008 123.3280090 0.0005561901 2.694071e-01 4.079213e-01 14 39114331 39114395 65 + 2.086 2.048 -0.125
ENSG00000092208 E009 118.9530984 0.0002515809 2.381039e-02 5.942466e-02 14 39114396 39114420 25 + 2.081 2.003 -0.262
ENSG00000092208 E010 127.8117984 0.0002687880 1.479916e-03 5.572429e-03 14 39114421 39114466 46 + 2.121 2.014 -0.360
ENSG00000092208 E011 117.2760360 0.0002979554 5.144360e-04 2.213403e-03 14 39114467 39114475 9 + 2.087 1.962 -0.419
ENSG00000092208 E012 216.2569202 0.0001814224 1.737631e-03 6.400596e-03 14 39114829 39114913 85 + 2.339 2.259 -0.267
ENSG00000092208 E013 197.7984084 0.0004387104 1.303682e-02 3.599747e-02 14 39117999 39118088 90 + 2.299 2.230 -0.231
ENSG00000092208 E014 155.1594022 0.0003608577 2.868888e-01 4.273421e-01 14 39118540 39118599 60 + 2.182 2.150 -0.108
ENSG00000092208 E015 0.9275265 0.0149896254 8.222842e-01 8.879449e-01 14 39121907 39122024 118 + 0.263 0.305 0.290
ENSG00000092208 E016 244.3082027 0.0004479345 7.683418e-01 8.503184e-01 14 39122430 39122543 114 + 2.365 2.371 0.021
ENSG00000092208 E017 1.5690626 0.1578365315 6.297723e-01 7.450819e-01 14 39122544 39122701 158 + 0.427 0.305 -0.712
ENSG00000092208 E018 133.7510679 0.0003890876 1.499700e-03 5.634603e-03 14 39124992 39125036 45 + 2.072 2.173 0.340
ENSG00000092208 E019 168.7391400 0.0002091335 7.397936e-03 2.225361e-02 14 39128280 39128348 69 + 2.182 2.258 0.254
ENSG00000092208 E020 2.5871574 0.0056866907 5.881102e-01 7.113475e-01 14 39131773 39131786 14 + 0.517 0.608 0.415
ENSG00000092208 E021 4.8045632 0.0037268570 8.029173e-01 8.744985e-01 14 39131787 39131957 171 + 0.746 0.784 0.151
ENSG00000092208 E022 232.0564228 0.0003528987 1.045378e-01 1.974179e-01 14 39131958 39132068 111 + 2.333 2.373 0.135
ENSG00000092208 E023 174.1246740 0.0002561390 3.502535e-01 4.944447e-01 14 39133661 39133719 59 + 2.212 2.239 0.090
ENSG00000092208 E024 1.3263991 0.0509824121 2.206304e-01 3.511769e-01 14 39133720 39133759 40 + 0.425 0.178 -1.712
ENSG00000092208 E025 1.0425102 0.0119398048 3.669179e-01 5.112642e-01 14 39133760 39133820 61 + 0.352 0.179 -1.294
ENSG00000092208 E026 4.3368765 0.0053570245 4.239851e-02 9.544161e-02 14 39133821 39134370 550 + 0.592 0.882 1.183
ENSG00000092208 E027 3.2736431 0.0778297133 3.433205e-01 4.873485e-01 14 39135931 39136155 225 + 0.544 0.741 0.849
ENSG00000092208 E028 287.5066175 0.0002812215 9.727511e-09 1.202354e-07 14 39136440 39136973 534 + 2.396 2.520 0.416