ENSG00000092201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216297 ENSG00000092201 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT16H protein_coding protein_coding 104.4277 68.20381 144.5216 5.059281 3.396643 1.083249 83.95729 35.95261 131.29748 2.782586 4.7185815 1.868379 0.7485333 0.5318333 0.90800000 0.3761667 1.421242e-10 1.236335e-13 FALSE TRUE
ENST00000557394 ENSG00000092201 HEK293_OSMI2_2hA HEK293_TMG_2hB SUPT16H protein_coding retained_intron 104.4277 68.20381 144.5216 5.059281 3.396643 1.083249 18.55376 30.77883 10.36533 5.728690 0.4476796 -1.569250 0.2314208 0.4461667 0.07186667 -0.3743000 1.236335e-13 1.236335e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092201 E001 10.072742 8.084255e-02 4.093293e-04 1.810347e-03 14 21351476 21351478 3 - 0.721 1.343 2.303
ENSG00000092201 E002 170.810934 1.184696e-02 6.359791e-15 2.157671e-13 14 21351479 21351546 68 - 1.974 2.489 1.722
ENSG00000092201 E003 4074.614418 6.645387e-03 2.059762e-13 5.600110e-12 14 21351547 21352818 1272 - 3.466 3.750 0.943
ENSG00000092201 E004 859.478254 8.975556e-04 2.568656e-06 1.952354e-05 14 21353488 21353559 72 - 2.858 2.982 0.413
ENSG00000092201 E005 494.334460 2.871169e-04 1.861362e-04 9.042014e-04 14 21353560 21353565 6 - 2.625 2.729 0.346
ENSG00000092201 E006 1222.022576 9.932003e-04 3.686310e-02 8.520746e-02 14 21353703 21353832 130 - 3.028 3.099 0.236
ENSG00000092201 E007 1249.450968 8.965883e-05 9.251183e-02 1.790423e-01 14 21354411 21354540 130 - 3.044 3.097 0.177
ENSG00000092201 E008 1.920817 7.666503e-03 3.080260e-01 4.502569e-01 14 21354541 21354943 403 - 0.372 0.572 1.009
ENSG00000092201 E009 1200.039912 6.841439e-05 6.150765e-04 2.588493e-03 14 21357197 21357366 170 - 3.020 3.093 0.243
ENSG00000092201 E010 626.044927 2.368330e-04 2.755380e-07 2.569396e-06 14 21357927 21358002 76 - 2.722 2.841 0.395
ENSG00000092201 E011 37.564289 4.255343e-03 1.605006e-05 1.017494e-04 14 21358003 21358314 312 - 1.618 1.316 -1.040
ENSG00000092201 E012 899.145931 2.095795e-04 1.073439e-02 3.053267e-02 14 21358315 21358427 113 - 2.895 2.965 0.233
ENSG00000092201 E013 944.983224 2.470714e-04 6.290129e-01 7.444670e-01 14 21359484 21359609 126 - 2.927 2.968 0.137
ENSG00000092201 E014 796.517000 2.646786e-04 1.203821e-01 2.205185e-01 14 21360415 21360533 119 - 2.848 2.906 0.194
ENSG00000092201 E015 734.230924 7.915688e-04 7.370142e-01 8.273003e-01 14 21360846 21360972 127 - 2.818 2.858 0.131
ENSG00000092201 E016 719.638891 5.527227e-04 2.288336e-01 3.610594e-01 14 21361078 21361213 136 - 2.818 2.830 0.039
ENSG00000092201 E017 637.085178 1.113288e-04 8.084700e-06 5.484181e-05 14 21362197 21362324 128 - 2.780 2.742 -0.126
ENSG00000092201 E018 774.484363 1.420473e-03 6.276659e-05 3.449950e-04 14 21362794 21362947 154 - 2.870 2.809 -0.204
ENSG00000092201 E019 763.652028 1.642304e-03 9.177443e-06 6.153386e-05 14 21363034 21363149 116 - 2.868 2.791 -0.256
ENSG00000092201 E020 741.286958 6.603495e-04 7.819564e-10 1.183316e-08 14 21363233 21363328 96 - 2.857 2.771 -0.287
ENSG00000092201 E021 567.569010 1.264817e-04 2.116964e-14 6.639943e-13 14 21363438 21363503 66 - 2.746 2.645 -0.334
ENSG00000092201 E022 680.710697 1.321847e-03 4.062798e-09 5.380531e-08 14 21364827 21364939 113 - 2.826 2.718 -0.359
ENSG00000092201 E023 530.313644 3.630339e-03 6.141726e-05 3.384664e-04 14 21365070 21365143 74 - 2.718 2.609 -0.364
ENSG00000092201 E024 581.527189 3.304996e-03 2.263722e-05 1.385908e-04 14 21366439 21366529 91 - 2.758 2.649 -0.364
ENSG00000092201 E025 673.568205 3.943519e-03 3.094285e-04 1.417867e-03 14 21368269 21368441 173 - 2.818 2.723 -0.315
ENSG00000092201 E026 690.853335 3.932832e-03 2.253124e-05 1.380446e-04 14 21369204 21369348 145 - 2.834 2.717 -0.388
ENSG00000092201 E027 360.219249 2.624200e-03 7.322552e-06 5.017853e-05 14 21369349 21369355 7 - 2.552 2.434 -0.396
ENSG00000092201 E028 3.914792 1.575753e-02 1.351627e-02 3.711632e-02 14 21369436 21369749 314 - 0.752 0.321 -2.090
ENSG00000092201 E029 521.441459 5.080549e-04 1.057895e-20 7.389937e-19 14 21369750 21369819 70 - 2.724 2.559 -0.549
ENSG00000092201 E030 520.618898 2.304391e-04 1.745800e-14 5.556729e-13 14 21369820 21369896 77 - 2.712 2.599 -0.374
ENSG00000092201 E031 687.788970 2.303720e-03 5.901925e-10 9.135567e-09 14 21370336 21370488 153 - 2.839 2.696 -0.476
ENSG00000092201 E032 632.392285 3.877814e-03 4.001572e-12 8.887289e-11 14 21371874 21371970 97 - 2.818 2.608 -0.699
ENSG00000092201 E033 451.535954 6.042296e-03 4.373839e-08 4.772003e-07 14 21371971 21372044 74 - 2.671 2.465 -0.686
ENSG00000092201 E034 2.169242 6.815378e-03 1.229737e-02 3.424769e-02 14 21372075 21372468 394 - 0.294 0.730 2.173
ENSG00000092201 E035 11.822004 2.960679e-02 5.955771e-01 7.176359e-01 14 21372469 21372717 249 - 1.089 1.052 -0.131
ENSG00000092201 E036 570.402497 3.725194e-03 7.913627e-16 3.028101e-14 14 21373338 21373430 93 - 2.782 2.528 -0.844
ENSG00000092201 E037 29.557972 2.133666e-02 4.376197e-19 2.517635e-17 14 21382975 21383769 795 - 0.951 1.856 3.157
ENSG00000092201 E038 550.034216 6.511108e-03 2.018672e-11 3.997819e-10 14 21383862 21384714 853 - 2.768 2.502 -0.886