ENSG00000092140

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000206595 ENSG00000092140 HEK293_OSMI2_2hA HEK293_TMG_2hB G2E3 protein_coding protein_coding 13.11442 1.312165 23.0736 0.01215496 0.9472502 4.125894 4.7611958 0.9931860 8.0381588 0.15557510 0.4819809 3.004070 0.49225000 0.75556667 0.34860000 -0.40696667 1.446046e-02 1.999281e-13 FALSE TRUE
ENST00000438909 ENSG00000092140 HEK293_OSMI2_2hA HEK293_TMG_2hB G2E3 protein_coding protein_coding 13.11442 1.312165 23.0736 0.01215496 0.9472502 4.125894 0.6162980 0.1007304 0.7720607 0.10073038 0.4375581 2.820229 0.05265833 0.07753333 0.03496667 -0.04256667 9.794724e-01 1.999281e-13 FALSE TRUE
ENST00000548934 ENSG00000092140 HEK293_OSMI2_2hA HEK293_TMG_2hB G2E3 protein_coding nonsense_mediated_decay 13.11442 1.312165 23.0736 0.01215496 0.9472502 4.125894 0.9261394 0.0000000 1.2468704 0.00000000 0.2912690 6.973692 0.04132083 0.00000000 0.05503333 0.05503333 3.433670e-02 1.999281e-13 TRUE FALSE
ENST00000549553 ENSG00000092140 HEK293_OSMI2_2hA HEK293_TMG_2hB G2E3 protein_coding processed_transcript 13.11442 1.312165 23.0736 0.01215496 0.9472502 4.125894 0.4835172 0.0715587 1.2011427 0.04915718 0.1284041 3.892386 0.06170833 0.05466667 0.05256667 -0.00210000 1.000000e+00 1.999281e-13 FALSE FALSE
MSTRG.9309.1 ENSG00000092140 HEK293_OSMI2_2hA HEK293_TMG_2hB G2E3 protein_coding   13.11442 1.312165 23.0736 0.01215496 0.9472502 4.125894 5.2666039 0.0000000 10.0262505 0.00000000 1.2026354 9.971005 0.23892083 0.00000000 0.43200000 0.43200000 1.999281e-13 1.999281e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092140 E001 1.1782197 0.0111267091 6.210196e-01 7.380626e-01 14 30559146 30559157 12 + 0.222 0.000 -10.428
ENSG00000092140 E002 1.3233924 0.0106415591 5.260237e-01 6.593114e-01 14 30559158 30559159 2 + 0.243 0.000 -10.593
ENSG00000092140 E003 40.9683519 0.0010559321 6.231315e-03 1.922238e-02 14 30559160 30559221 62 + 1.361 1.176 -0.652
ENSG00000092140 E004 58.4401041 0.0017745671 1.231050e-02 3.427872e-02 14 30559222 30559272 51 + 1.506 1.401 -0.362
ENSG00000092140 E005 1.3244365 0.0239963671 7.487997e-01 8.359256e-01 14 30559310 30560842 1533 + 0.222 0.356 0.931
ENSG00000092140 E006 0.2903454 0.2850129944 1.000000e+00   14 30574535 30574590 56 + 0.067 0.000 -8.419
ENSG00000092140 E007 0.1817044 0.0422404550 2.279285e-02   14 30577756 30577760 5 + 0.000 0.356 15.015
ENSG00000092140 E008 0.1817044 0.0422404550 2.279285e-02   14 30577761 30577846 86 + 0.000 0.356 15.015
ENSG00000092140 E009 1.1331657 0.0292421866 1.136334e-01 2.108266e-01 14 30580864 30580947 84 + 0.151 0.550 2.615
ENSG00000092140 E010 55.6809957 0.0010085491 1.429771e-03 5.406287e-03 14 30581076 30581116 41 + 1.490 1.303 -0.648
ENSG00000092140 E011 80.3358923 0.0007141690 3.327083e-04 1.511199e-03 14 30586718 30586815 98 + 1.644 1.481 -0.558
ENSG00000092140 E012 75.5964559 0.0003534420 1.257589e-04 6.401550e-04 14 30589383 30589484 102 + 1.620 1.422 -0.676
ENSG00000092140 E013 1.4769841 0.0089083050 4.511098e-01 5.921086e-01 14 30590532 30590963 432 + 0.263 0.000 -10.745
ENSG00000092140 E014 71.5955441 0.0010507183 2.368706e-03 8.364049e-03 14 30592323 30592447 125 + 1.593 1.462 -0.447
ENSG00000092140 E015 75.0138621 0.0003488797 1.685296e-04 8.288963e-04 14 30593474 30593591 118 + 1.614 1.422 -0.658
ENSG00000092140 E016 54.8139437 0.0004296397 1.316684e-01 2.364668e-01 14 30593592 30593639 48 + 1.470 1.462 -0.025
ENSG00000092140 E017 71.2599151 0.0004069629 2.605441e-02 6.405890e-02 14 30597420 30597526 107 + 1.583 1.532 -0.174
ENSG00000092140 E018 9.0905198 0.0021973782 9.470815e-01 9.707709e-01 14 30598100 30598482 383 + 0.747 0.867 0.474
ENSG00000092140 E019 67.6164810 0.0006088171 1.238488e-02 3.445899e-02 14 30598483 30598557 75 + 1.564 1.481 -0.285
ENSG00000092140 E020 55.0351865 0.0004113609 3.674178e-01 5.117991e-01 14 30598558 30598599 42 + 1.467 1.516 0.167
ENSG00000092140 E021 79.5503469 0.0003511787 4.544199e-02 1.010085e-01 14 30601770 30601894 125 + 1.628 1.607 -0.073
ENSG00000092140 E022 67.3701533 0.0013467155 6.586159e-02 1.364801e-01 14 30601999 30602131 133 + 1.558 1.533 -0.087
ENSG00000092140 E023 0.4439371 0.0216106609 1.000000e+00 1.000000e+00 14 30602631 30602746 116 + 0.097 0.000 -9.009
ENSG00000092140 E024 0.5891098 0.0182272918 1.000000e+00 1.000000e+00 14 30602747 30602889 143 + 0.125 0.000 -9.423
ENSG00000092140 E025 123.1272969 0.0009488912 2.855938e-02 6.913126e-02 14 30605505 30605812 308 + 1.814 1.810 -0.014
ENSG00000092140 E026 95.2647292 0.0002898605 9.101864e-01 9.469035e-01 14 30607888 30608069 182 + 1.694 1.827 0.451
ENSG00000092140 E027 4.4986921 0.0037438769 2.857697e-01 4.261312e-01 14 30611302 30612206 905 + 0.533 0.356 -0.925
ENSG00000092140 E028 89.6144849 0.0016533304 6.674528e-01 7.746787e-01 14 30612207 30612379 173 + 1.664 1.819 0.523
ENSG00000092140 E029 96.6031999 0.0003047046 6.760035e-01 7.811049e-01 14 30615349 30615539 191 + 1.701 1.802 0.341
ENSG00000092140 E030 387.2570565 0.0233234095 4.289796e-08 4.690575e-07 14 30616278 30620064 3787 + 2.254 2.699 1.483