ENSG00000092096

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354772 ENSG00000092096 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A17 protein_coding protein_coding 5.354856 7.029983 4.142276 0.6671199 0.1591481 -0.7616697 2.7862297 4.1998317 2.4342623 0.62072256 0.1487901 -0.7843635 0.51645000 0.59653333 0.58966667 -0.006866667 0.98779149 0.01086429 FALSE  
ENST00000397260 ENSG00000092096 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A17 protein_coding nonsense_mediated_decay 5.354856 7.029983 4.142276 0.6671199 0.1591481 -0.7616697 0.2530328 0.1407813 0.4154073 0.07265754 0.2084496 1.4963873 0.04703333 0.01970000 0.09743333 0.077733333 0.67725097 0.01086429 FALSE  
ENST00000397267 ENSG00000092096 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A17 protein_coding protein_coding 5.354856 7.029983 4.142276 0.6671199 0.1591481 -0.7616697 0.9714744 1.4490752 0.5773736 0.18039406 0.2127967 -1.3127038 0.18407917 0.20910000 0.13890000 -0.070200000 0.61443216 0.01086429 FALSE  
ENST00000473917 ENSG00000092096 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A17 protein_coding retained_intron 5.354856 7.029983 4.142276 0.6671199 0.1591481 -0.7616697 0.3966733 0.5208174 0.1035147 0.20794179 0.1035147 -2.2253363 0.07269583 0.07936667 0.02506667 -0.054300000 0.35524321 0.01086429 TRUE  
ENST00000557699 ENSG00000092096 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A17 protein_coding retained_intron 5.354856 7.029983 4.142276 0.6671199 0.1591481 -0.7616697 0.4711749 0.2552764 0.5130745 0.03876214 0.1290748 0.9795204 0.09533750 0.03626667 0.12453333 0.088266667 0.01086429 0.01086429 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092096 E001 1.8735995 0.4548472959 0.9041490686 0.942994382 14 23346314 23346315 2 - 0.451 0.439 -0.060
ENSG00000092096 E002 1.8735995 0.4548472959 0.9041490686 0.942994382 14 23346316 23346317 2 - 0.451 0.439 -0.060
ENSG00000092096 E003 3.4538202 0.2419074187 0.8750084001 0.923699043 14 23346318 23346323 6 - 0.622 0.621 -0.006
ENSG00000092096 E004 56.0743813 0.0120614877 0.5444922525 0.674966457 14 23346324 23346602 279 - 1.683 1.730 0.159
ENSG00000092096 E005 81.9886619 0.0045998835 0.0225703187 0.056863120 14 23346603 23346936 334 - 1.793 1.908 0.390
ENSG00000092096 E006 41.1979664 0.0005536242 0.3077244108 0.449963995 14 23347101 23347158 58 - 1.538 1.597 0.203
ENSG00000092096 E007 39.8828985 0.0005748470 0.9992246685 1.000000000 14 23347159 23347212 54 - 1.566 1.566 0.000
ENSG00000092096 E008 8.2345121 0.0187263577 0.2862638271 0.426662759 14 23347460 23347513 54 - 0.813 0.960 0.559
ENSG00000092096 E009 68.7250082 0.0030305270 0.2604846493 0.398012964 14 23347514 23347731 218 - 1.759 1.818 0.198
ENSG00000092096 E010 41.3237605 0.0005853460 0.7106849009 0.807811425 14 23347891 23347996 106 - 1.566 1.587 0.073
ENSG00000092096 E011 55.5692978 0.0004270140 0.5114410743 0.646474267 14 23348161 23348306 146 - 1.684 1.716 0.111
ENSG00000092096 E012 29.9805405 0.0007091071 0.9888163143 0.997031627 14 23348506 23348546 41 - 1.448 1.447 -0.003
ENSG00000092096 E013 29.7386472 0.0007299510 0.4473964023 0.588788745 14 23348547 23348626 80 - 1.476 1.426 -0.173
ENSG00000092096 E014 22.4688929 0.0008376148 0.6496055860 0.760838393 14 23348627 23348671 45 - 1.353 1.319 -0.119
ENSG00000092096 E015 9.2446900 0.0206269369 0.0002299988 0.001091771 14 23348672 23349271 600 - 1.232 0.785 -1.654
ENSG00000092096 E016 33.5425212 0.0012707604 0.9691586225 0.984718114 14 23349272 23349330 59 - 1.495 1.498 0.010
ENSG00000092096 E017 43.8917252 0.0005488660 0.0673005427 0.138863443 14 23349331 23349426 96 - 1.679 1.582 -0.333
ENSG00000092096 E018 0.4720498 0.2135749777 0.3010493980 0.442815812 14 23349427 23349762 336 - 0.282 0.090 -1.984
ENSG00000092096 E019 1.8154127 0.0406402739 0.0277990705 0.067616554 14 23350919 23351672 754 - 0.670 0.283 -2.001
ENSG00000092096 E020 43.3037199 0.0033071134 0.7023047966 0.801146096 14 23351752 23351855 104 - 1.622 1.600 -0.075
ENSG00000092096 E021 44.6655885 0.0006837206 0.3399423462 0.483876491 14 23351948 23352127 180 - 1.649 1.597 -0.176
ENSG00000092096 E022 35.7756068 0.0227013835 0.3327081454 0.476381858 14 23352128 23352405 278 - 1.571 1.496 -0.259
ENSG00000092096 E023 20.7841204 0.0254755754 0.6408438582 0.754008635 14 23352406 23352451 46 - 1.326 1.280 -0.163
ENSG00000092096 E024 0.2955422 0.0288224959 0.6161649223   14 23352452 23352576 125 - 0.164 0.090 -0.995
ENSG00000092096 E025 31.8678654 0.0352754956 0.9738035593 0.987676608 14 23352646 23352912 267 - 1.469 1.473 0.013