ENSG00000092094

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000554249 ENSG00000092094 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGEP protein_coding retained_intron 55.63199 67.21669 50.83732 6.00745 1.19508 -0.4028623 2.917453 0.8078085 4.272429 0.1443065 0.2171310 2.3885943 0.05500000 0.01203333 0.08420000 0.07216667 2.074261e-19 2.074261e-19 FALSE TRUE
ENST00000555223 ENSG00000092094 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGEP protein_coding nonsense_mediated_decay 55.63199 67.21669 50.83732 6.00745 1.19508 -0.4028623 4.805321 4.3303425 4.739699 0.8814807 1.0720344 0.1300272 0.08654167 0.06346667 0.09363333 0.03016667 5.877451e-01 2.074261e-19 TRUE FALSE
ENST00000556124 ENSG00000092094 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGEP protein_coding retained_intron 55.63199 67.21669 50.83732 6.00745 1.19508 -0.4028623 3.102692 1.2776157 4.173580 0.3653760 0.2356130 1.7000360 0.05798750 0.01866667 0.08196667 0.06330000 3.116056e-07 2.074261e-19   FALSE
MSTRG.9152.10 ENSG00000092094 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGEP protein_coding   55.63199 67.21669 50.83732 6.00745 1.19508 -0.4028623 25.598967 35.1434929 22.807820 3.6586472 0.9161755 -0.6235071 0.45726667 0.52153333 0.44870000 -0.07283333 5.622626e-02 2.074261e-19 FALSE TRUE
MSTRG.9152.3 ENSG00000092094 HEK293_OSMI2_2hA HEK293_TMG_2hB OSGEP protein_coding   55.63199 67.21669 50.83732 6.00745 1.19508 -0.4028623 8.106931 16.2269143 4.157338 1.2340008 0.9592732 -1.9620796 0.13902917 0.24330000 0.08110000 -0.16220000 5.845958e-05 2.074261e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000092094 E001 0.0000000       14 20446401 20446410 10 -      
ENSG00000092094 E002 0.6599951 0.0175653836 1.131276e-01 2.100934e-01 14 20446411 20446991 581 - 0.000 0.295 10.629
ENSG00000092094 E003 2.6557497 0.1160527186 2.450150e-01 3.800402e-01 14 20446992 20447062 71 - 0.363 0.630 1.324
ENSG00000092094 E004 2.8374541 0.0798156402 1.530212e-01 2.657810e-01 14 20447063 20447064 2 - 0.363 0.657 1.439
ENSG00000092094 E005 4.4249600 0.0357016189 9.075842e-03 2.646927e-02 14 20447065 20447066 2 - 0.363 0.829 2.137
ENSG00000092094 E006 4.8678504 0.0197482121 2.805319e-03 9.690381e-03 14 20447067 20447068 2 - 0.363 0.862 2.265
ENSG00000092094 E007 5.3795524 0.0043172801 4.800595e-04 2.083811e-03 14 20447069 20447072 4 - 0.363 0.905 2.430
ENSG00000092094 E008 7.8936397 0.0026916133 3.745646e-04 1.675643e-03 14 20447073 20447085 13 - 0.558 1.030 1.896
ENSG00000092094 E009 98.1149445 0.0003125076 3.676876e-11 6.972705e-10 14 20447086 20447138 53 - 1.789 2.039 0.840
ENSG00000092094 E010 425.8968848 0.0001424531 2.735911e-09 3.744475e-08 14 20447139 20447279 141 - 2.542 2.634 0.307
ENSG00000092094 E011 5.0575231 0.1401621600 8.803150e-01 9.272355e-01 14 20447280 20447421 142 - 0.729 0.748 0.074
ENSG00000092094 E012 527.7518383 0.0002731006 3.146266e-09 4.252644e-08 14 20447422 20447520 99 - 2.639 2.725 0.286
ENSG00000092094 E013 334.4884507 0.0001709093 6.988840e-06 4.814774e-05 14 20447615 20447630 16 - 2.449 2.525 0.253
ENSG00000092094 E014 472.3254865 0.0001318820 1.264054e-06 1.027245e-05 14 20447631 20447677 47 - 2.605 2.671 0.221
ENSG00000092094 E015 347.1990908 0.0021769651 2.495548e-03 8.750701e-03 14 20447678 20447690 13 - 2.465 2.536 0.235
ENSG00000092094 E016 30.1981279 0.0051875117 1.253432e-13 3.512705e-12 14 20447691 20447903 213 - 1.760 1.217 -1.869
ENSG00000092094 E017 488.9367599 0.0001797260 3.811387e-04 1.701838e-03 14 20447904 20447994 91 - 2.635 2.679 0.143
ENSG00000092094 E018 9.8513621 0.0057296456 4.457974e-10 7.049076e-09 14 20447995 20448023 29 - 1.357 0.667 -2.580
ENSG00000092094 E019 16.9897635 0.0011569021 8.003088e-19 4.473771e-17 14 20448024 20448105 82 - 1.595 0.835 -2.715
ENSG00000092094 E020 489.8619612 0.0001343332 1.762011e-04 8.619733e-04 14 20448106 20448171 66 - 2.635 2.680 0.151
ENSG00000092094 E021 559.8638584 0.0001235876 3.049025e-03 1.041016e-02 14 20448733 20448811 79 - 2.705 2.733 0.094
ENSG00000092094 E022 13.0896684 0.0083393385 7.927903e-02 1.583616e-01 14 20448812 20448901 90 - 1.244 1.049 -0.698
ENSG00000092094 E023 21.7367628 0.0095120339 2.615927e-06 1.985097e-05 14 20448902 20448963 62 - 1.570 1.155 -1.443
ENSG00000092094 E024 502.3015532 0.0001163133 2.460503e-01 3.813120e-01 14 20448964 20449013 50 - 2.677 2.678 0.002
ENSG00000092094 E025 54.7169002 0.0178421341 3.998483e-16 1.591388e-14 14 20449014 20449170 157 - 2.056 1.379 -2.300
ENSG00000092094 E026 446.1509675 0.0001399573 8.660641e-01 9.177588e-01 14 20449171 20449207 37 - 2.641 2.619 -0.072
ENSG00000092094 E027 364.3324327 0.0001652018 5.836179e-01 7.076902e-01 14 20449208 20449221 14 - 2.558 2.528 -0.098
ENSG00000092094 E028 482.2606310 0.0001540720 7.848230e-01 8.620317e-01 14 20449222 20449266 45 - 2.675 2.651 -0.079
ENSG00000092094 E029 37.9431771 0.0007393396 2.263416e-20 1.509318e-18 14 20449267 20449301 35 - 1.857 1.316 -1.850
ENSG00000092094 E030 198.5955511 0.0178727963 1.581297e-27 2.159856e-25 14 20449302 20450879 1578 - 2.639 1.852 -2.633
ENSG00000092094 E031 41.7386838 0.0010715778 2.065015e-18 1.093379e-16 14 20451257 20451452 196 - 1.878 1.377 -1.704
ENSG00000092094 E032 14.0015366 0.0013995245 1.955219e-24 2.025207e-22 14 20451959 20451973 15 - 1.570 0.565 -3.756
ENSG00000092094 E033 301.6201064 0.0001770942 5.104300e-01 6.456433e-01 14 20451974 20451977 4 - 2.477 2.444 -0.111
ENSG00000092094 E034 342.4669854 0.0001472792 6.531111e-01 7.636778e-01 14 20451978 20451994 17 - 2.517 2.507 -0.033
ENSG00000092094 E035 474.1230368 0.0017385579 7.916369e-01 8.667319e-01 14 20451995 20452149 155 - 2.670 2.637 -0.110
ENSG00000092094 E036 13.0930357 0.0012784580 6.060105e-21 4.342166e-19 14 20452150 20452275 126 - 1.527 0.593 -3.484
ENSG00000092094 E037 18.2477059 0.0268366602 1.136863e-13 3.203561e-12 14 20452276 20452328 53 - 1.649 0.766 -3.173
ENSG00000092094 E038 321.6068365 0.0058413733 1.682773e-01 2.859595e-01 14 20452329 20452448 120 - 2.459 2.486 0.090
ENSG00000092094 E039 4.0534542 0.0094475237 3.768089e-02 8.673161e-02 14 20454565 20454568 4 - 0.877 0.565 -1.290
ENSG00000092094 E040 421.1621701 0.0077265838 4.399568e-01 5.816779e-01 14 20454569 20455089 521 - 2.592 2.595 0.011