ENSG00000091986

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000206423 ENSG00000091986 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC80 protein_coding protein_coding 1.385121 1.122036 1.682618 0.2369465 0.05712411 0.5803366 0.06325151 0.05752503 0.09392423 0.005718925 0.006072721 0.62203770 0.05187917 0.05810000 0.05590000 -0.00220000 1.000000000 0.002369816 FALSE TRUE
ENST00000439685 ENSG00000091986 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC80 protein_coding protein_coding 1.385121 1.122036 1.682618 0.2369465 0.05712411 0.5803366 0.70255240 0.89912134 0.86850105 0.116991484 0.035044340 -0.04942884 0.55681667 0.83500000 0.51593333 -0.31906667 0.053013445 0.002369816 FALSE TRUE
ENST00000461431 ENSG00000091986 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC80 protein_coding protein_coding 1.385121 1.122036 1.682618 0.2369465 0.05712411 0.5803366 0.14824674 0.00000000 0.00000000 0.000000000 0.000000000 0.00000000 0.09912083 0.00000000 0.00000000 0.00000000   0.002369816 FALSE TRUE
ENST00000469554 ENSG00000091986 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC80 protein_coding processed_transcript 1.385121 1.122036 1.682618 0.2369465 0.05712411 0.5803366 0.22807237 0.12088898 0.17236451 0.120888980 0.111503687 0.47848136 0.15160833 0.07813333 0.09956667 0.02143333 0.850594010 0.002369816   FALSE
ENST00000475181 ENSG00000091986 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC80 protein_coding processed_transcript 1.385121 1.122036 1.682618 0.2369465 0.05712411 0.5803366 0.16173169 0.04450026 0.54782771 0.044500262 0.092587760 3.35548452 0.10268750 0.02876667 0.32853333 0.29976667 0.002369816 0.002369816 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091986 E001 10.269608 0.0019201589 0.043309584 0.09713010 3 112596797 112605100 8304 - 1.148 0.944 -0.745
ENSG00000091986 E002 8.504654 0.0021483541 0.132061656 0.23698076 3 112605101 112605466 366 - 0.895 1.056 0.598
ENSG00000091986 E003 13.676774 0.0015227951 0.101760605 0.19318230 3 112605467 112605599 133 - 1.094 1.236 0.505
ENSG00000091986 E004 14.777456 0.0027461150 0.028703769 0.06941248 3 112605600 112605763 164 - 1.094 1.282 0.667
ENSG00000091986 E005 9.179469 0.0025365756 0.004201957 0.01370842 3 112607176 112607256 81 - 0.816 1.125 1.152
ENSG00000091986 E006 12.026895 0.0017030132 0.076099471 0.15326769 3 112609978 112610081 104 - 1.020 1.184 0.593
ENSG00000091986 E007 0.147249 0.0444094697 0.500186667   3 112610082 112610280 199 - 0.123 0.000 -9.164
ENSG00000091986 E008 15.453890 0.0013304596 0.142041998 0.25082894 3 112616710 112616858 149 - 1.148 1.268 0.425
ENSG00000091986 E009 14.818863 0.0013814691 0.829409814 0.89288101 3 112618968 112619104 137 - 1.186 1.202 0.057
ENSG00000091986 E010 13.583862 0.0016514312 0.117637782 0.21656989 3 112630113 112630269 157 - 1.083 1.220 0.490
ENSG00000091986 E011 38.279965 0.0006031825 0.362648224 0.50706033 3 112638028 112639399 1372 - 1.571 1.615 0.152
ENSG00000091986 E012 16.783834 0.0015694173 0.089482762 0.17433941 3 112639400 112639916 517 - 1.320 1.184 -0.480
ENSG00000091986 E013 2.868038 0.0061568258 0.157735888 0.27210138 3 112640327 112640431 105 - 0.692 0.470 -1.007
ENSG00000091986 E014 4.348242 0.0040369420 0.033335433 0.07845383 3 112640432 112640563 132 - 0.857 0.556 -1.254
ENSG00000091986 E015 6.076672 0.0034436293 0.005838810 0.01818749 3 112640564 112640720 157 - 1.006 0.660 -1.356
ENSG00000091986 E016 4.081655 0.0042151279 0.238770403 0.37272855 3 112640721 112640765 45 - 0.794 0.628 -0.686
ENSG00000091986 E017 6.840099 0.0028279967 0.005968857 0.01852532 3 112640766 112640837 72 - 1.046 0.718 -1.262
ENSG00000091986 E018 6.009837 0.0029760586 0.005688935 0.01778820 3 112640838 112640923 86 - 1.006 0.660 -1.356
ENSG00000091986 E019 5.152064 0.0330978262 0.199905309 0.32612949 3 112640924 112641038 115 - 0.895 0.713 -0.718
ENSG00000091986 E020 4.573665 0.0036749524 0.140455985 0.24865868 3 112641039 112641300 262 - 0.857 0.659 -0.798
ENSG00000091986 E021 0.000000       3 112643262 112643457 196 -      
ENSG00000091986 E022 0.000000       3 112649316 112649530 215 -