ENSG00000091732

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358303 ENSG00000091732 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3HC1 protein_coding protein_coding 37.00241 53.03589 29.30127 2.477893 0.7565466 -0.8557854 31.568097 46.620815 23.547834 2.010170 0.5436954 -0.9850767 0.8503208 0.87936667 0.8040333 -0.07533333 0.00159645 0.00159645 FALSE  
MSTRG.30679.7 ENSG00000091732 HEK293_OSMI2_2hA HEK293_TMG_2hB ZC3HC1 protein_coding   37.00241 53.03589 29.30127 2.477893 0.7565466 -0.8557854 2.959062 4.239758 2.806745 0.388178 0.1881913 -0.5933518 0.0775500 0.08026667 0.0958000 0.01553333 0.59897565 0.00159645 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091732 E001 0.9566832 0.0129876205 9.231864e-01 9.555584e-01 7 130018287 130018291 5 - 0.291 0.276 -0.101
ENSG00000091732 E002 2.9398777 0.0188252753 1.749838e-01 2.946470e-01 7 130018292 130018292 1 - 0.385 0.635 1.215
ENSG00000091732 E003 11.1393188 0.0043265536 6.333459e-02 1.322518e-01 7 130018293 130018314 22 - 0.885 1.106 0.817
ENSG00000091732 E004 60.2667496 0.0022597189 1.073241e-01 2.015907e-01 7 130018315 130018325 11 - 1.678 1.774 0.323
ENSG00000091732 E005 99.3706172 0.0046745773 3.817626e-04 1.704303e-03 7 130018326 130018356 31 - 1.812 2.007 0.659
ENSG00000091732 E006 593.7829820 0.0013247137 9.928421e-09 1.225269e-07 7 130018357 130018732 376 - 2.629 2.764 0.447
ENSG00000091732 E007 464.1789428 0.0005458070 3.477301e-02 8.120860e-02 7 130022319 130022525 207 - 2.588 2.636 0.157
ENSG00000091732 E008 266.4631897 0.0001791806 2.316115e-01 3.643847e-01 7 130023511 130023563 53 - 2.359 2.393 0.114
ENSG00000091732 E009 363.0401244 0.0009557608 3.377517e-01 4.816522e-01 7 130023564 130023676 113 - 2.496 2.524 0.093
ENSG00000091732 E010 240.2119091 0.0001746039 2.596840e-02 6.388142e-02 7 130023677 130023723 47 - 2.294 2.356 0.207
ENSG00000091732 E011 373.4299437 0.0003760821 1.476033e-01 2.584309e-01 7 130024263 130024377 115 - 2.503 2.539 0.120
ENSG00000091732 E012 354.0864545 0.0001915953 2.564018e-01 3.933544e-01 7 130024378 130024506 129 - 2.485 2.514 0.097
ENSG00000091732 E013 307.7606115 0.0003939462 2.012168e-01 3.277103e-01 7 130026158 130026235 78 - 2.462 2.437 -0.082
ENSG00000091732 E014 297.2085601 0.0002024920 1.282535e-05 8.310157e-05 7 130026236 130026312 77 - 2.493 2.403 -0.301
ENSG00000091732 E015 366.2928747 0.0002502374 2.964134e-05 1.766313e-04 7 130028902 130029029 128 - 2.576 2.497 -0.263
ENSG00000091732 E016 2.6301033 0.1321095398 6.160075e-01 7.341472e-01 7 130036650 130036966 317 - 0.587 0.483 -0.489
ENSG00000091732 E017 1.6575531 0.0089345236 2.333731e-01 3.664106e-01 7 130039275 130039341 67 - 0.529 0.325 -1.098
ENSG00000091732 E018 240.4950766 0.0002348504 1.906637e-03 6.936279e-03 7 130039464 130039506 43 - 2.387 2.316 -0.237
ENSG00000091732 E019 173.8876011 0.0004213063 1.386189e-01 2.461863e-01 7 130039507 130039518 12 - 2.225 2.185 -0.131
ENSG00000091732 E020 190.4928749 0.0003088715 6.292487e-01 7.446531e-01 7 130039519 130039547 29 - 2.243 2.234 -0.028
ENSG00000091732 E021 1.1414950 0.0123820110 3.004629e-01 4.421556e-01 7 130039548 130039626 79 - 0.169 0.368 1.483
ENSG00000091732 E022 257.2537844 0.0002181524 7.193999e-01 8.142488e-01 7 130040951 130041101 151 - 2.370 2.367 -0.011
ENSG00000091732 E023 0.7436440 0.1306054747 6.588957e-01 7.678706e-01 7 130043387 130043431 45 - 0.291 0.218 -0.545
ENSG00000091732 E024 2.2738346 0.1201089426 5.505282e-04 2.348743e-03 7 130043628 130043880 253 - 0.856 0.160 -3.792
ENSG00000091732 E025 1.9034283 0.1676568962 6.555280e-03 2.006914e-02 7 130045316 130045488 173 - 0.762 0.162 -3.409
ENSG00000091732 E026 6.0818774 0.0029262069 2.006370e-02 5.161888e-02 7 130048974 130049032 59 - 1.002 0.718 -1.100
ENSG00000091732 E027 221.7169870 0.0011396242 3.013216e-03 1.030443e-02 7 130049033 130049144 112 - 2.360 2.277 -0.277
ENSG00000091732 E028 0.9201370 0.0144487960 5.667791e-01 6.936613e-01 7 130050443 130050488 46 - 0.169 0.277 0.903
ENSG00000091732 E029 188.0506044 0.0018800513 5.346452e-08 5.726341e-07 7 130051221 130051451 231 - 2.350 2.173 -0.592