ENSG00000091656

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518282 ENSG00000091656 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFHX4 protein_coding protein_coding 2.440524 1.73066 2.221203 0.2369652 0.1374295 0.358188 1.14960000 1.5801617 0.2512384 0.1883667 0.1256284 -2.605735 0.5060667 0.9194333 0.1203000 -0.7991333 9.733161e-03 9.161026e-07 FALSE TRUE
ENST00000651020 ENSG00000091656 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFHX4 protein_coding protein_coding 2.440524 1.73066 2.221203 0.2369652 0.1374295 0.358188 0.04578524 0.0000000 0.1206765 0.0000000 0.0809447 3.707928 0.0170250 0.0000000 0.0509000 0.0509000 1.536067e-01 9.161026e-07 FALSE TRUE
ENST00000651372 ENSG00000091656 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFHX4 protein_coding protein_coding 2.440524 1.73066 2.221203 0.2369652 0.1374295 0.358188 1.13115365 0.1420391 1.6481973 0.1020103 0.1363013 3.447101 0.4347417 0.0757000 0.7401667 0.6644667 9.161026e-07 9.161026e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091656 E001 0.1451727 0.0441657647 5.591496e-01   8 76681239 76681246 8 + 0.079 0.000 -16.550
ENSG00000091656 E002 0.2966881 0.0275312307 2.434018e-01   8 76681247 76681279 33 + 0.147 0.000 -17.551
ENSG00000091656 E003 8.8188384 0.0018791264 2.577956e-11 5.020932e-10 8 76681280 76681620 341 + 1.080 0.493 -2.386
ENSG00000091656 E004 0.0000000       8 76682527 76682632 106 +      
ENSG00000091656 E005 0.2987644 0.0269058847 2.437961e-01   8 76683781 76683955 175 + 0.147 0.000 -17.551
ENSG00000091656 E006 0.0000000       8 76693406 76693432 27 +      
ENSG00000091656 E007 0.0000000       8 76693433 76693506 74 +      
ENSG00000091656 E008 0.0000000       8 76703598 76703618 21 +      
ENSG00000091656 E009 3.4471225 0.0046962734 7.047103e-06 4.850494e-05 8 76704043 76704044 2 + 0.734 0.184 -3.064
ENSG00000091656 E010 69.1084907 0.0004116289 1.489887e-47 7.995883e-45 8 76704045 76706538 2494 + 1.891 1.561 -1.119
ENSG00000091656 E011 7.9047214 0.0421574317 7.371969e-04 3.033048e-03 8 76706539 76706678 140 + 0.975 0.762 -0.819
ENSG00000091656 E012 3.2901948 0.0046634450 1.654170e-04 8.154291e-04 8 76707546 76707623 78 + 0.700 0.313 -1.927
ENSG00000091656 E013 14.5356971 0.2025571675 7.288690e-03 2.197219e-02 8 76707624 76708048 425 + 1.215 1.020 -0.704
ENSG00000091656 E014 0.1482932 0.0435894222 4.240373e-01   8 76708049 76708258 210 + 0.000 0.184 19.062
ENSG00000091656 E015 0.0000000       8 76776388 76776575 188 +      
ENSG00000091656 E016 3.7367824 0.0772161018 3.253707e-01 4.688169e-01 8 76778208 76778281 74 + 0.623 0.717 0.394
ENSG00000091656 E017 3.1424758 0.1882239384 5.755809e-01 7.011495e-01 8 76778282 76778287 6 + 0.555 0.672 0.511
ENSG00000091656 E018 10.7101528 0.0174672780 2.540089e-04 1.191886e-03 8 76778288 76778439 152 + 1.073 0.951 -0.448
ENSG00000091656 E019 0.2944980 0.3239195347 3.293552e-01   8 76782143 76782218 76 + 0.146 0.000 -17.549
ENSG00000091656 E020 8.3563616 0.0020585150 1.125797e-06 9.246463e-06 8 76833338 76833406 69 + 1.010 0.718 -1.128
ENSG00000091656 E021 0.0000000       8 76833407 76833626 220 +      
ENSG00000091656 E022 0.2987644 0.0269058847 2.437961e-01   8 76834121 76834434 314 + 0.147 0.000 -17.551
ENSG00000091656 E023 7.8712121 0.1193243013 1.083758e-02 3.077559e-02 8 76842655 76842771 117 + 0.967 0.769 -0.763
ENSG00000091656 E024 8.2615388 0.0028798749 2.088588e-06 1.618376e-05 8 76848995 76849128 134 + 1.001 0.718 -1.096
ENSG00000091656 E025 7.7939910 0.0199321751 6.753142e-04 2.808884e-03 8 76849512 76849712 201 + 0.956 0.799 -0.601
ENSG00000091656 E026 0.0000000       8 76849800 76850244 445 +      
ENSG00000091656 E027 6.6429404 0.0031139878 3.037247e-03 1.037500e-02 8 76850245 76850362 118 + 0.870 0.798 -0.282
ENSG00000091656 E028 187.5300018 0.0111849052 2.041575e-08 2.376760e-07 8 76850886 76856300 5415 + 2.203 2.315 0.371
ENSG00000091656 E029 389.8788648 0.0262538660 2.084512e-20 1.399378e-18 8 76863094 76867281 4188 + 2.178 2.916 2.458