ENSG00000091651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000219097 ENSG00000091651 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC6 protein_coding protein_coding 49.05979 27.94327 74.01976 2.024506 0.8190637 1.405088 32.925619 22.4410724 49.944428 2.1938511 1.10406526 1.153828 0.66512917 0.80036667 0.67470000 -0.12566667 0.003168791 0.003168791 FALSE TRUE
ENST00000563306 ENSG00000091651 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC6 protein_coding retained_intron 49.05979 27.94327 74.01976 2.024506 0.8190637 1.405088 3.230742 1.1342588 5.151693 0.1298764 0.20801761 2.173431 0.06632083 0.04123333 0.06963333 0.02840000 0.034042475 0.003168791 FALSE TRUE
ENST00000569239 ENSG00000091651 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC6 protein_coding retained_intron 49.05979 27.94327 74.01976 2.024506 0.8190637 1.405088 5.341261 1.6748835 8.241513 0.2411357 0.07626549 2.292010 0.11055417 0.06143333 0.11136667 0.04993333 0.042124494 0.003168791 FALSE TRUE
MSTRG.12566.5 ENSG00000091651 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC6 protein_coding   49.05979 27.94327 74.01976 2.024506 0.8190637 1.405088 5.088791 0.7877273 7.956927 0.3743369 0.15704223 3.320056 0.10048333 0.02856667 0.10750000 0.07893333 0.042561976 0.003168791 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091651 E001 10.322832 0.0123212087 9.695792e-01 9.849688e-01 16 46689643 46689658 16 + 1.025 1.036 0.040
ENSG00000091651 E002 83.980256 0.0041321972 1.975027e-01 3.230890e-01 16 46689659 46689681 23 + 1.921 1.863 -0.197
ENSG00000091651 E003 91.447574 0.0028507298 5.299621e-02 1.144783e-01 16 46689682 46689696 15 + 1.965 1.881 -0.281
ENSG00000091651 E004 137.935494 0.0003413629 1.994036e-04 9.612810e-04 16 46689697 46689706 10 + 2.152 2.037 -0.385
ENSG00000091651 E005 225.464893 0.0002267216 2.127199e-02 5.415896e-02 16 46689707 46689770 64 + 2.343 2.295 -0.162
ENSG00000091651 E006 9.085343 0.0019189433 1.683643e-01 2.860603e-01 16 46689771 46689829 59 + 1.017 0.859 -0.592
ENSG00000091651 E007 4.595980 0.0445988262 8.681505e-02 1.702996e-01 16 46690786 46690990 205 + 0.800 0.488 -1.353
ENSG00000091651 E008 253.747043 0.0001671669 5.913724e-04 2.502093e-03 16 46690991 46691057 67 + 2.401 2.329 -0.241
ENSG00000091651 E009 249.208279 0.0002166460 4.550204e-01 5.955897e-01 16 46691058 46691120 63 + 2.373 2.366 -0.024
ENSG00000091651 E010 333.772490 0.0001345527 8.977644e-02 1.747894e-01 16 46692382 46692545 164 + 2.483 2.528 0.152
ENSG00000091651 E011 280.951220 0.0002142710 3.615615e-02 8.389068e-02 16 46693093 46693182 90 + 2.404 2.462 0.194
ENSG00000091651 E012 60.266500 0.0264810323 4.688967e-04 2.041202e-03 16 46693183 46694519 1337 + 1.839 1.501 -1.147
ENSG00000091651 E013 16.528755 0.0011267836 1.450228e-03 5.474353e-03 16 46694937 46694938 2 + 1.296 0.992 -1.090
ENSG00000091651 E014 44.782059 0.0004937869 8.196378e-09 1.026765e-07 16 46694939 46695084 146 + 1.718 1.358 -1.233
ENSG00000091651 E015 16.642586 0.0500419690 3.286499e-02 7.753768e-02 16 46695085 46695108 24 + 1.295 0.975 -1.150
ENSG00000091651 E016 84.927388 0.0074481462 1.454455e-06 1.166761e-05 16 46695109 46695561 453 + 1.979 1.680 -1.008
ENSG00000091651 E017 379.478462 0.0008343508 3.800033e-01 5.242650e-01 16 46695562 46695674 113 + 2.557 2.547 -0.033
ENSG00000091651 E018 44.619905 0.0005492794 1.093752e-03 4.282837e-03 16 46695675 46696016 342 + 1.684 1.500 -0.629
ENSG00000091651 E019 343.440199 0.0001460664 3.380293e-01 4.819030e-01 16 46696017 46696085 69 + 2.512 2.504 -0.028
ENSG00000091651 E020 26.806778 0.0340814739 4.349630e-01 5.772071e-01 16 46696086 46696219 134 + 1.445 1.362 -0.289
ENSG00000091651 E021 1013.647476 0.0007563552 2.141972e-19 1.281308e-17 16 46697458 46698394 937 + 2.931 3.067 0.450