ENSG00000091527

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264993 ENSG00000091527 HEK293_OSMI2_2hA HEK293_TMG_2hB CDV3 protein_coding protein_coding 89.71821 73.47245 122.3658 4.314121 2.632868 0.7358469 30.241417 18.110517 51.327075 0.8176288 1.9108908 1.5023770 0.3261333 0.24810000 0.41936667 0.17126667 1.353218e-06 1.353218e-06 FALSE TRUE
ENST00000420115 ENSG00000091527 HEK293_OSMI2_2hA HEK293_TMG_2hB CDV3 protein_coding protein_coding 89.71821 73.47245 122.3658 4.314121 2.632868 0.7358469 14.139757 9.228153 18.807265 0.8647918 0.9652443 1.0263806 0.1521833 0.12653333 0.15370000 0.02716667 4.761396e-01 1.353218e-06 FALSE FALSE
ENST00000515421 ENSG00000091527 HEK293_OSMI2_2hA HEK293_TMG_2hB CDV3 protein_coding protein_coding 89.71821 73.47245 122.3658 4.314121 2.632868 0.7358469 8.789953 20.760111 4.206658 6.3197166 1.3089437 -2.3003371 0.1204125 0.27800000 0.03486667 -0.24313333 3.551827e-04 1.353218e-06 FALSE FALSE
MSTRG.23727.5 ENSG00000091527 HEK293_OSMI2_2hA HEK293_TMG_2hB CDV3 protein_coding   89.71821 73.47245 122.3658 4.314121 2.632868 0.7358469 11.622895 4.999750 21.456483 1.1078322 0.6403076 2.0992752 0.1200833 0.07023333 0.17533333 0.10510000 1.469633e-02 1.353218e-06 FALSE TRUE
MSTRG.23727.8 ENSG00000091527 HEK293_OSMI2_2hA HEK293_TMG_2hB CDV3 protein_coding   89.71821 73.47245 122.3658 4.314121 2.632868 0.7358469 20.999076 18.063165 23.751227 2.7497972 2.3083540 0.3947602 0.2383417 0.24746667 0.19360000 -0.05386667 5.977349e-01 1.353218e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091527 E001 83.4961481 2.812897e-03 1.124599e-06 9.237826e-06 3 133573686 133573747 62 + 1.962 1.811 -0.509
ENSG00000091527 E002 165.0054652 1.025162e-02 3.176652e-09 4.290348e-08 3 133573748 133573970 223 + 2.287 2.020 -0.893
ENSG00000091527 E003 65.0472675 8.567205e-03 8.292279e-09 1.037751e-07 3 133573971 133573975 5 + 1.895 1.588 -1.038
ENSG00000091527 E004 104.7539352 4.197418e-04 8.944488e-27 1.131179e-24 3 133573976 133574044 69 + 2.108 1.768 -1.146
ENSG00000091527 E005 130.8727984 2.958896e-03 1.703953e-20 1.155364e-18 3 133574045 133574180 136 + 2.201 1.874 -1.096
ENSG00000091527 E006 165.5939640 7.623950e-04 1.562090e-18 8.395272e-17 3 133574181 133574284 104 + 2.273 2.076 -0.657
ENSG00000091527 E007 0.6203429 3.337391e-02 6.229822e-01 7.396728e-01 3 133574412 133574433 22 + 0.163 0.285 1.023
ENSG00000091527 E008 0.6203429 3.337391e-02 6.229822e-01 7.396728e-01 3 133574434 133574456 23 + 0.163 0.285 1.023
ENSG00000091527 E009 2.3217790 8.900574e-03 3.761514e-01 5.205200e-01 3 133574457 133574497 41 + 0.545 0.456 -0.435
ENSG00000091527 E010 2.9568838 1.542147e-02 5.917600e-01 7.144507e-01 3 133574498 133574551 54 + 0.598 0.578 -0.093
ENSG00000091527 E011 2.7742490 5.426016e-03 1.652423e-01 2.819888e-01 3 133574552 133574592 41 + 0.623 0.456 -0.783
ENSG00000091527 E012 0.4449813 2.123701e-02 8.988491e-01 9.394867e-01 3 133574593 133574637 45 + 0.163 0.165 0.022
ENSG00000091527 E013 0.0000000       3 133574638 133574647 10 +      
ENSG00000091527 E014 1.0351233 1.199303e-02 2.045454e-02 5.244847e-02 3 133574648 133574742 95 + 0.415 0.000 -11.785
ENSG00000091527 E015 0.7363589 1.549277e-02 6.073768e-02 1.278728e-01 3 133574743 133574756 14 + 0.331 0.000 -11.299
ENSG00000091527 E016 303.3067473 1.868555e-03 1.090633e-07 1.100256e-06 3 133575039 133575115 77 + 2.496 2.427 -0.231
ENSG00000091527 E017 223.2863052 2.831848e-03 5.888500e-06 4.125892e-05 3 133584002 133584004 3 + 2.365 2.292 -0.242
ENSG00000091527 E018 619.3239917 9.433394e-04 1.046018e-03 4.118312e-03 3 133584005 133584150 146 + 2.772 2.794 0.074
ENSG00000091527 E019 350.9572396 3.008665e-04 2.123084e-01 3.412566e-01 3 133586563 133586568 6 + 2.510 2.574 0.212
ENSG00000091527 E020 760.7289201 9.085791e-05 1.097805e-05 7.225902e-05 3 133586569 133586722 154 + 2.857 2.888 0.102
ENSG00000091527 E021 117.0950084 2.737005e-04 6.022251e-01 7.232172e-01 3 133587159 133587161 3 + 2.016 2.122 0.355
ENSG00000091527 E022 693.3308373 1.636384e-03 1.063340e-10 1.868186e-09 3 133587162 133587895 734 + 2.851 2.786 -0.216
ENSG00000091527 E023 1063.6921415 4.303559e-03 1.586139e-05 1.006597e-04 3 133587896 133588352 457 + 3.031 2.980 -0.171
ENSG00000091527 E024 4549.2338483 1.802085e-03 3.375960e-33 7.224310e-31 3 133588353 133590261 1909 + 3.547 3.770 0.739