ENSG00000091483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366560 ENSG00000091483 HEK293_OSMI2_2hA HEK293_TMG_2hB FH protein_coding protein_coding 64.83572 48.2976 85.33078 4.498919 0.4398338 0.820985 23.54870 22.97504 26.12579 2.696560 2.117688 0.1853316 0.3805 0.4748333 0.3062667 -0.1685667 0.003784308 0.001807928 FALSE TRUE
MSTRG.3360.1 ENSG00000091483 HEK293_OSMI2_2hA HEK293_TMG_2hB FH protein_coding   64.83572 48.2976 85.33078 4.498919 0.4398338 0.820985 38.09766 24.45731 54.14244 2.337837 1.016935 1.1461708 0.5733 0.5075000 0.6344667 0.1269667 0.021009438 0.001807928 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091483 E001 0.2966881 0.0290785164 3.124755e-01   1 241486276 241486319 44 - 0.193 0.000 -11.312
ENSG00000091483 E002 0.4396707 0.0283156925 1.520810e-01 2.645204e-01 1 241497511 241497580 70 - 0.264 0.000 -11.896
ENSG00000091483 E003 0.4396707 0.0283156925 1.520810e-01 2.645204e-01 1 241497581 241497587 7 - 0.264 0.000 -11.896
ENSG00000091483 E004 0.2924217 0.0290785164 3.125381e-01   1 241497588 241497602 15 - 0.193 0.000 -11.311
ENSG00000091483 E005 2.1953654 0.3781737739 2.489040e-01 3.846458e-01 1 241497603 241497638 36 - 0.324 0.627 1.543
ENSG00000091483 E006 5.8405593 0.0515371269 4.469842e-01 5.884139e-01 1 241497639 241497658 20 - 0.779 0.877 0.380
ENSG00000091483 E007 154.3566998 0.0016343696 2.188305e-04 1.044488e-03 1 241497659 241497860 202 - 2.135 2.253 0.394
ENSG00000091483 E008 437.7366674 0.0001893280 8.882466e-07 7.459027e-06 1 241497861 241497970 110 - 2.608 2.687 0.261
ENSG00000091483 E009 8.0283455 0.0042737437 1.630350e-01 2.790940e-01 1 241498738 241500436 1699 - 1.021 0.850 -0.643
ENSG00000091483 E010 650.1478003 0.0005711021 1.346293e-07 1.334159e-06 1 241500437 241500590 154 - 2.777 2.858 0.270
ENSG00000091483 E011 3.9348343 0.3420029397 5.193390e-01 6.534577e-01 1 241500591 241502442 1852 - 0.761 0.579 -0.771
ENSG00000091483 E012 626.5258822 0.0002090027 1.757778e-03 6.464875e-03 1 241502443 241502570 128 - 2.783 2.822 0.129
ENSG00000091483 E013 4.9843922 0.0033513477 2.179255e-01 3.479326e-01 1 241502571 241504041 1471 - 0.854 0.681 -0.694
ENSG00000091483 E014 713.9310856 0.0001716573 4.477018e-07 3.998480e-06 1 241504042 241504245 204 - 2.829 2.891 0.205
ENSG00000091483 E015 584.6162280 0.0001582015 2.690154e-05 1.618526e-04 1 241506003 241506168 166 - 2.745 2.800 0.185
ENSG00000091483 E016 561.8718934 0.0001658321 6.091645e-01 7.287011e-01 1 241508603 241508760 158 - 2.753 2.753 0.001
ENSG00000091483 E017 300.3321537 0.0001626329 5.955419e-01 7.176071e-01 1 241508761 241508785 25 - 2.490 2.472 -0.060
ENSG00000091483 E018 27.1580146 0.0386164424 3.120787e-05 1.849424e-04 1 241508786 241510555 1770 - 1.621 1.086 -1.866
ENSG00000091483 E019 3.5841412 0.2652928686 7.742559e-03 2.313166e-02 1 241511867 241511966 100 - 0.873 0.138 -4.110
ENSG00000091483 E020 604.5255676 0.0001489298 2.505927e-05 1.518975e-04 1 241511967 241512143 177 - 2.817 2.747 -0.231
ENSG00000091483 E021 461.5924443 0.0004398907 8.386053e-10 1.260483e-08 1 241513603 241513713 111 - 2.721 2.597 -0.414
ENSG00000091483 E022 448.2701735 0.0011545044 2.851817e-12 6.496731e-11 1 241517182 241517316 135 - 2.726 2.554 -0.573
ENSG00000091483 E023 1.9626617 0.0072712554 4.070477e-01 5.506691e-01 1 241519060 241519088 29 - 0.546 0.401 -0.728
ENSG00000091483 E024 4.0889181 0.0101959403 1.981287e-01 3.238669e-01 1 241519089 241519590 502 - 0.799 0.605 -0.808
ENSG00000091483 E025 277.1514280 0.0044888038 9.145795e-07 7.656062e-06 1 241519591 241519799 209 - 2.530 2.324 -0.687