ENSG00000091436

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338983 ENSG00000091436 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K20 protein_coding protein_coding 7.253014 4.121512 10.97598 0.1706951 0.380168 1.410922 2.0223907 0.7764444 3.6848031 0.02683487 0.08947769 2.2320808 0.2508875 0.1889000 0.33600000 0.14710000 0.0003830051 0.0003830051 FALSE TRUE
ENST00000375213 ENSG00000091436 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K20 protein_coding protein_coding 7.253014 4.121512 10.97598 0.1706951 0.380168 1.410922 4.4334380 2.4035608 5.7645011 0.68980961 0.25097976 1.2585332 0.5863583 0.5718667 0.52613333 -0.04573333 0.8964873342 0.0003830051 FALSE TRUE
ENST00000409176 ENSG00000091436 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K20 protein_coding protein_coding 7.253014 4.121512 10.97598 0.1706951 0.380168 1.410922 0.3730185 0.7737730 0.9205516 0.58368042 0.31795037 0.2476503 0.0999375 0.1992333 0.08286667 -0.11636667 0.9992442547 0.0003830051 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091436 E001 1.0675023 0.0113771276 3.684034e-01 5.128213e-01 2 173075435 173075670 236 + 0.349 0.181 -1.256
ENSG00000091436 E002 1.3535813 0.0465834753 2.249955e-01 3.564090e-01 2 173075714 173075815 102 + 0.422 0.181 -1.669
ENSG00000091436 E003 0.5891098 0.0183041205 2.099426e-01 3.384654e-01 2 173075836 173075841 6 + 0.260 0.000 -11.228
ENSG00000091436 E004 0.5891098 0.0183041205 2.099426e-01 3.384654e-01 2 173075842 173075845 4 + 0.260 0.000 -11.228
ENSG00000091436 E005 0.8815316 0.0132271145 8.767003e-02 1.715912e-01 2 173075846 173075853 8 + 0.349 0.000 -11.858
ENSG00000091436 E006 2.9497018 0.0053806686 4.499122e-04 1.966240e-03 2 173075854 173075867 14 + 0.708 0.000 -13.529
ENSG00000091436 E007 18.2304636 0.0028123759 7.821561e-02 1.565990e-01 2 173075868 173076002 135 + 1.308 1.158 -0.528
ENSG00000091436 E008 0.0000000       2 173090619 173090830 212 +      
ENSG00000091436 E009 51.7497592 0.0033713181 2.991980e-01 4.406948e-01 2 173090998 173091190 193 + 1.714 1.661 -0.179
ENSG00000091436 E010 0.0000000       2 173160010 173160407 398 +      
ENSG00000091436 E011 45.7611991 0.0009084461 1.866002e-01 3.094680e-01 2 173169805 173169892 88 + 1.664 1.598 -0.224
ENSG00000091436 E012 57.2001660 0.0004694403 9.641527e-01 9.814086e-01 2 173182854 173182955 102 + 1.734 1.746 0.039
ENSG00000091436 E013 53.0208448 0.0004927986 2.610955e-01 3.987205e-01 2 173187558 173187623 66 + 1.680 1.746 0.224
ENSG00000091436 E014 44.1550651 0.0005382160 4.095524e-01 5.531563e-01 2 173190895 173190923 29 + 1.607 1.662 0.187
ENSG00000091436 E015 72.2972062 0.0003965338 8.904247e-01 9.340024e-01 2 173191040 173191177 138 + 1.833 1.849 0.052
ENSG00000091436 E016 76.2590442 0.0003714802 8.975721e-01 9.386152e-01 2 173198026 173198112 87 + 1.858 1.861 0.013
ENSG00000091436 E017 76.1400876 0.0003893785 8.902775e-02 1.736440e-01 2 173203796 173203870 75 + 1.881 1.816 -0.218
ENSG00000091436 E018 94.4387324 0.0002999728 2.074733e-02 5.305348e-02 2 173209729 173209835 107 + 1.978 1.897 -0.273
ENSG00000091436 E019 13.0977269 0.0013611534 4.544496e-03 1.466571e-02 2 173209836 173212825 2990 + 1.019 1.291 0.974
ENSG00000091436 E020 80.3655794 0.0005473324 5.583695e-01 6.866222e-01 2 173217115 173217250 136 + 1.889 1.873 -0.052
ENSG00000091436 E021 319.4309155 0.0001660190 6.074024e-23 5.352119e-21 2 173221150 173227146 5997 + 2.533 2.336 -0.658
ENSG00000091436 E022 21.1500422 0.0615604018 5.207575e-01 6.547119e-01 2 173229689 173229733 45 + 1.291 1.368 0.267
ENSG00000091436 E023 17.8335614 0.0200744759 5.418547e-01 6.727533e-01 2 173232192 173232222 31 + 1.226 1.291 0.228
ENSG00000091436 E024 32.9308426 0.0028360089 9.600305e-01 9.788904e-01 2 173232320 173232459 140 + 1.500 1.511 0.039
ENSG00000091436 E025 26.4217483 0.0008111545 8.415198e-01 9.011605e-01 2 173238373 173238435 63 + 1.416 1.411 -0.018
ENSG00000091436 E026 36.3252111 0.0006136048 4.955106e-01 6.323032e-01 2 173239404 173239496 93 + 1.558 1.525 -0.113
ENSG00000091436 E027 45.1758402 0.0024657986 8.132573e-02 1.616285e-01 2 173258699 173258815 117 + 1.600 1.711 0.378
ENSG00000091436 E028 38.7494446 0.0041036517 2.152942e-02 5.470338e-02 2 173261063 173261137 75 + 1.516 1.675 0.540
ENSG00000091436 E029 29.0348188 0.0007611362 9.014278e-02 1.753440e-01 2 173263745 173263792 48 + 1.409 1.531 0.421
ENSG00000091436 E030 44.6108896 0.0038869758 2.510795e-01 3.872338e-01 2 173263793 173263895 103 + 1.604 1.685 0.274
ENSG00000091436 E031 221.9566826 0.0015840868 3.893956e-20 2.521183e-18 2 173266050 173268015 1966 + 2.217 2.481 0.882