ENSG00000091164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000590954 ENSG00000091164 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNL1 protein_coding protein_coding 19.91538 15.03905 28.54661 2.449542 0.6997547 0.9241522 5.039071 5.784746 3.685952 1.9910580 0.4201267 -0.6487994 0.2648792 0.3642000 0.1288333 -0.2353667 0.001203754 0.0002012624 FALSE TRUE
MSTRG.15827.7 ENSG00000091164 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNL1 protein_coding   19.91538 15.03905 28.54661 2.449542 0.6997547 0.9241522 13.898493 8.960258 22.221202 0.4361424 0.8044505 1.3093647 0.6862958 0.6173667 0.7784667 0.1611000 0.136724352 0.0002012624 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091164 E001 12.8736231 0.0468759678 3.565534e-02 8.291351e-02 18 56597209 56599067 1859 - 1.242 0.947 -1.066
ENSG00000091164 E002 7.2988715 0.0030513716 9.181889e-02 1.779630e-01 18 56599068 56600102 1035 - 0.983 0.779 -0.782
ENSG00000091164 E003 3.2956191 0.0049874003 1.171658e-02 3.285675e-02 18 56600103 56600365 263 - 0.765 0.353 -1.945
ENSG00000091164 E004 1.4706534 0.2694191213 3.874980e-01 5.316392e-01 18 56600366 56600433 68 - 0.480 0.258 -1.315
ENSG00000091164 E005 0.4407149 0.0217681645 8.970437e-01 9.382491e-01 18 56600434 56600501 68 - 0.178 0.151 -0.282
ENSG00000091164 E006 2.2748657 0.0654144141 2.054245e-01 3.329424e-01 18 56600502 56600637 136 - 0.606 0.352 -1.282
ENSG00000091164 E007 3.1606491 0.1354215647 2.362030e-01 3.697791e-01 18 56600638 56600865 228 - 0.703 0.432 -1.249
ENSG00000091164 E008 14.0367561 0.1113126439 4.424536e-02 9.883913e-02 18 56600866 56602821 1956 - 1.296 0.896 -1.449
ENSG00000091164 E009 2.0671486 0.0109141052 5.922869e-01 7.148490e-01 18 56602822 56602823 2 - 0.516 0.427 -0.450
ENSG00000091164 E010 61.6178479 0.0005259015 2.018166e-03 7.282443e-03 18 56602824 56602897 74 - 1.730 1.876 0.493
ENSG00000091164 E011 249.8794894 0.0034146666 1.141839e-05 7.488159e-05 18 56602898 56603056 159 - 2.326 2.482 0.520
ENSG00000091164 E012 0.8200183 0.0160309421 9.358258e-01 9.636288e-01 18 56604436 56604478 43 - 0.246 0.264 0.134
ENSG00000091164 E013 1.4007090 0.0105309075 3.127219e-01 4.552504e-01 18 56605182 56605272 91 - 0.443 0.264 -1.088
ENSG00000091164 E014 7.2899180 0.0022895168 3.715820e-04 1.664540e-03 18 56608279 56610992 2714 - 1.057 0.594 -1.831
ENSG00000091164 E015 300.6555531 0.0016644615 1.294967e-06 1.049979e-05 18 56610993 56611097 105 - 2.418 2.552 0.445
ENSG00000091164 E016 364.1782581 0.0001662055 2.686892e-07 2.510845e-06 18 56614424 56614596 173 - 2.518 2.618 0.333
ENSG00000091164 E017 216.3868412 0.0002085689 2.103500e-01 3.389687e-01 18 56616245 56616314 70 - 2.321 2.359 0.125
ENSG00000091164 E018 179.0741280 0.0024169298 2.283033e-01 3.604072e-01 18 56618004 56618040 37 - 2.232 2.279 0.156
ENSG00000091164 E019 215.7441021 0.0015484900 1.756694e-01 2.955598e-01 18 56618041 56618126 86 - 2.313 2.360 0.156
ENSG00000091164 E020 323.6271068 0.0002028651 2.361569e-04 1.117307e-03 18 56624288 56624461 174 - 2.537 2.471 -0.219
ENSG00000091164 E021 1.4048617 0.0096201361 3.111107e-01 4.535548e-01 18 56626162 56626266 105 - 0.443 0.264 -1.088
ENSG00000091164 E022 207.9155268 0.0002081044 9.291985e-07 7.764474e-06 18 56626361 56626457 97 - 2.363 2.246 -0.389
ENSG00000091164 E023 87.0843694 0.0011032698 6.584695e-04 2.746418e-03 18 56638343 56638358 16 - 1.995 1.859 -0.457
ENSG00000091164 E024 254.3868005 0.0016200856 2.669191e-06 2.020741e-05 18 56638359 56638505 147 - 2.456 2.321 -0.448
ENSG00000091164 E025 184.8706366 0.0023816092 4.365847e-05 2.495088e-04 18 56638506 56638703 198 - 2.320 2.178 -0.477
ENSG00000091164 E026 1.1081736 0.0123787843 5.973809e-01 7.191552e-01 18 56638704 56638926 223 - 0.356 0.264 -0.602
ENSG00000091164 E027 0.7415557 0.1106513304 4.201394e-01 5.633668e-01 18 56638927 56638961 35 - 0.304 0.151 -1.290
ENSG00000091164 E028 2.3731757 0.0070082049 2.333158e-02 5.844140e-02 18 56638962 56639039 78 - 0.658 0.263 -2.090
ENSG00000091164 E029 0.0000000       18 56647063 56647448 386 -      
ENSG00000091164 E030 6.6232734 0.0029146421 4.001902e-02 9.107214e-02 18 56647449 56647535 87 - 0.972 0.714 -1.004
ENSG00000091164 E031 6.4008858 0.0042259043 8.330254e-04 3.376787e-03 18 56651017 56651600 584 - 1.006 0.545 -1.866