ENSG00000091136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000222399 ENSG00000091136 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB1 protein_coding protein_coding 13.55961 19.50356 12.00562 1.569939 0.4958283 -0.6995662 8.979305 7.786495 10.67666926 1.0155697 0.06974117 0.4549147 0.69742917 0.4086667 0.892000000 0.4833333 5.323920e-05 1.1082e-16 FALSE TRUE
ENST00000491196 ENSG00000091136 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB1 protein_coding retained_intron 13.55961 19.50356 12.00562 1.569939 0.4958283 -0.6995662 1.013630 3.546597 0.21794271 0.9504513 0.21794271 -3.9637543 0.05910417 0.1767667 0.017433333 -0.1593333 4.081773e-02 1.1082e-16 FALSE FALSE
ENST00000676744 ENSG00000091136 HEK293_OSMI2_2hA HEK293_TMG_2hB LAMB1 protein_coding retained_intron 13.55961 19.50356 12.00562 1.569939 0.4958283 -0.6995662 2.227724 6.890572 0.07435326 1.0178068 0.03784852 -6.3541283 0.13242917 0.3529000 0.005933333 -0.3469667 1.108200e-16 1.1082e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091136 E001 138.0820945 0.0017392594 8.369963e-30 1.383651e-27 7 107923799 107924087 289 - 1.845 2.280 1.456
ENSG00000091136 E002 144.0880485 0.0026339397 7.517552e-23 6.566057e-21 7 107924230 107924389 160 - 1.891 2.287 1.328
ENSG00000091136 E003 1.2512699 0.0103186371 1.277357e-01 2.310092e-01 7 107924390 107926182 1793 - 0.480 0.212 -1.682
ENSG00000091136 E004 148.4590983 0.0013545326 4.443077e-17 1.992726e-15 7 107926183 107926359 177 - 1.979 2.272 0.981
ENSG00000091136 E005 0.3289534 0.0294466688 9.602157e-01   7 107926360 107928645 2286 - 0.126 0.119 -0.097
ENSG00000091136 E006 0.2944980 0.3353543302 2.620172e-01   7 107928857 107929021 165 - 0.223 0.000 -13.997
ENSG00000091136 E007 0.4460135 0.0258268870 7.460946e-02 1.509085e-01 7 107929022 107929063 42 - 0.303 0.000 -14.589
ENSG00000091136 E008 58.2968105 0.0010905552 2.031369e-06 1.577967e-05 7 107929064 107929065 2 - 1.620 1.856 0.798
ENSG00000091136 E009 149.4874201 0.0016591482 4.481559e-11 8.383706e-10 7 107929066 107929205 140 - 2.027 2.260 0.780
ENSG00000091136 E010 0.0000000       7 107929206 107929411 206 -      
ENSG00000091136 E011 179.7097153 0.0035309061 1.094513e-04 5.655107e-04 7 107929412 107929619 208 - 2.161 2.312 0.507
ENSG00000091136 E012 0.5932745 0.0344745392 9.400293e-01 9.663379e-01 7 107929620 107929792 173 - 0.224 0.211 -0.104
ENSG00000091136 E013 0.1472490 0.0428324598 4.590770e-01   7 107931217 107931355 139 - 0.126 0.000 -13.003
ENSG00000091136 E014 148.0525121 0.0006180635 3.900125e-02 8.919960e-02 7 107931356 107931500 145 - 2.131 2.196 0.216
ENSG00000091136 E015 0.4439371 0.0215566368 7.378491e-02 1.495728e-01 7 107931501 107931738 238 - 0.303 0.000 -14.589
ENSG00000091136 E016 171.6515836 0.0027235639 1.591931e-02 4.255070e-02 7 107932174 107932377 204 - 2.181 2.270 0.298
ENSG00000091136 E017 1.2263901 0.1344556510 7.086970e-01 8.062918e-01 7 107932378 107932406 29 - 0.371 0.293 -0.489
ENSG00000091136 E018 1.2200474 0.0116614110 6.439547e-01 7.563817e-01 7 107932407 107932493 87 - 0.370 0.289 -0.510
ENSG00000091136 E019 2.6508421 0.0085218850 5.257136e-01 6.590536e-01 7 107932494 107934799 2306 - 0.480 0.584 0.491
ENSG00000091136 E020 0.3332198 0.0294235705 9.595515e-01   7 107935356 107935358 3 - 0.126 0.119 -0.098
ENSG00000091136 E021 0.3332198 0.0294235705 9.595515e-01   7 107935359 107935373 15 - 0.126 0.119 -0.098
ENSG00000091136 E022 0.6934063 0.1251130638 6.055974e-02 1.275712e-01 7 107935374 107935391 18 - 0.000 0.353 14.532
ENSG00000091136 E023 1.2115396 0.0119430909 2.947114e-01 4.358280e-01 7 107935392 107935414 23 - 0.224 0.411 1.225
ENSG00000091136 E024 169.7150410 0.0007725457 2.113275e-03 7.575425e-03 7 107935415 107935656 242 - 2.170 2.262 0.310
ENSG00000091136 E025 0.0000000       7 107935657 107936278 622 -      
ENSG00000091136 E026 0.0000000       7 107936279 107936373 95 -      
ENSG00000091136 E027 0.4355181 0.6814977912 2.763438e-01 4.157996e-01 7 107936374 107937092 719 - 0.302 0.000 -14.566
ENSG00000091136 E028 142.2016533 0.0014736869 7.013387e-02 1.435898e-01 7 107937093 107937277 185 - 2.110 2.174 0.215
ENSG00000091136 E029 0.0000000       7 107937278 107937318 41 -      
ENSG00000091136 E030 146.6541142 0.0002802325 1.674980e-01 2.849419e-01 7 107939989 107940358 370 - 2.183 2.144 -0.133
ENSG00000091136 E031 3.1794749 0.0050221962 5.281448e-02 1.141612e-01 7 107940359 107941802 1444 - 0.757 0.461 -1.320
ENSG00000091136 E032 5.2815840 0.1569871457 1.802689e-02 4.718999e-02 7 107942436 107942619 184 - 0.429 0.957 2.257
ENSG00000091136 E033 0.4418608 0.0298553822 7.490410e-02 1.513767e-01 7 107950623 107951158 536 - 0.303 0.000 -14.588
ENSG00000091136 E034 0.3729606 0.0300448486 9.609485e-01 9.794100e-01 7 107951159 107951225 67 - 0.126 0.119 -0.095
ENSG00000091136 E035 68.4164475 0.0003700962 4.783733e-01 6.167914e-01 7 107951226 107951322 97 - 1.817 1.848 0.106
ENSG00000091136 E036 115.0125309 0.0002806640 5.375464e-01 6.690925e-01 7 107952009 107952223 215 - 2.048 2.070 0.072
ENSG00000091136 E037 125.1781242 0.0002558865 1.890169e-01 3.125103e-01 7 107953530 107953754 225 - 2.119 2.079 -0.135
ENSG00000091136 E038 94.6744700 0.0002798204 9.461729e-03 2.744177e-02 7 107955467 107955630 164 - 2.025 1.933 -0.311
ENSG00000091136 E039 0.0000000       7 107958293 107958508 216 -      
ENSG00000091136 E040 100.2375435 0.0002935576 4.925070e-01 6.296792e-01 7 107959249 107959480 232 - 2.011 1.988 -0.078
ENSG00000091136 E041 0.2965864 0.2609574888 2.852702e-01   7 107959506 107959690 185 - 0.000 0.208 13.499
ENSG00000091136 E042 80.0915691 0.0006054952 2.022835e-01 3.290799e-01 7 107959691 107959834 144 - 1.932 1.882 -0.169
ENSG00000091136 E043 121.9646076 0.0003717699 6.070792e-04 2.558948e-03 7 107960445 107960649 205 - 2.143 2.033 -0.367
ENSG00000091136 E044 87.7232660 0.0088727286 1.187059e-02 3.322175e-02 7 107961206 107961329 124 - 2.020 1.876 -0.484
ENSG00000091136 E045 79.0707361 0.0067949816 4.503125e-02 1.002601e-01 7 107961549 107961676 128 - 1.955 1.847 -0.364
ENSG00000091136 E046 86.5051939 0.0055686271 3.657163e-03 1.217450e-02 7 107962905 107963063 159 - 2.011 1.865 -0.492
ENSG00000091136 E047 85.8555790 0.0003470059 7.824473e-04 3.196729e-03 7 107964552 107964687 136 - 2.000 1.873 -0.427
ENSG00000091136 E048 65.5724961 0.0003956887 1.673430e-03 6.197851e-03 7 107972992 107973071 80 - 1.887 1.751 -0.458
ENSG00000091136 E049 66.6311398 0.0003806352 1.054099e-01 1.987242e-01 7 107974986 107975098 113 - 1.860 1.791 -0.233
ENSG00000091136 E050 0.0000000       7 107975230 107975233 4 -      
ENSG00000091136 E051 87.8939399 0.0059914018 1.530509e-03 5.735457e-03 7 107975234 107975413 180 - 2.028 1.865 -0.546
ENSG00000091136 E052 86.1666446 0.0076685844 4.191471e-05 2.404280e-04 7 107975689 107975877 189 - 2.049 1.822 -0.764
ENSG00000091136 E053 60.1058051 0.0004180875 1.383944e-08 1.662057e-07 7 107978047 107978167 121 - 1.906 1.648 -0.871
ENSG00000091136 E054 65.0570635 0.0038244342 2.248315e-07 2.134592e-06 7 107980609 107980811 203 - 1.944 1.673 -0.913
ENSG00000091136 E055 42.4147461 0.0120275204 1.432310e-03 5.414592e-03 7 107986022 107986085 64 - 1.753 1.515 -0.807
ENSG00000091136 E056 70.5315121 0.0070322758 2.556819e-05 1.546705e-04 7 107986175 107986363 189 - 1.970 1.729 -0.811
ENSG00000091136 E057 42.0579522 0.0020675748 2.242918e-08 2.590150e-07 7 107994887 107994960 74 - 1.780 1.458 -1.097
ENSG00000091136 E058 32.6575163 0.0146950970 4.831889e-04 2.095858e-03 7 107998357 107998397 41 - 1.664 1.373 -0.998
ENSG00000091136 E059 46.0064761 0.0005021979 4.212240e-10 6.688427e-09 7 107998398 107998492 95 - 1.819 1.494 -1.105
ENSG00000091136 E060 50.2137050 0.0009110754 2.078880e-10 3.472075e-09 7 108001558 108001733 176 - 1.853 1.528 -1.103
ENSG00000091136 E061 0.1515154 0.0427349063 4.585955e-01   7 108001734 108001946 213 - 0.126 0.000 -13.004
ENSG00000091136 E062 0.1482932 0.0418576002 5.189976e-01   7 108001947 108001998 52 - 0.000 0.119 12.531
ENSG00000091136 E063 0.3697384 0.0249002102 2.182845e-01 3.483413e-01 7 108001999 108002126 128 - 0.000 0.212 13.535
ENSG00000091136 E064 1.0726966 0.0121989077 1.083365e-01 2.030814e-01 7 108002127 108002384 258 - 0.126 0.411 2.225
ENSG00000091136 E065 1.0255820 0.3980660980 7.688848e-01 8.506460e-01 7 108002385 108002848 464 - 0.224 0.357 0.916
ENSG00000091136 E066 30.1623264 0.0223005471 2.379920e-03 8.398097e-03 7 108002849 108002971 123 - 1.624 1.333 -1.001
ENSG00000091136 E067 1.3608545 0.0105961384 7.343903e-02 1.490264e-01 7 108002972 108003110 139 - 0.526 0.212 -1.906
ENSG00000091136 E068 14.8598846 0.0012088795 3.278972e-05 1.932527e-04 7 108003111 108003213 103 - 1.359 0.992 -1.312