ENSG00000091129

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351718 ENSG00000091129 HEK293_OSMI2_2hA HEK293_TMG_2hB NRCAM protein_coding protein_coding 2.618145 1.752464 4.561998 0.1922217 0.1620277 1.375231 1.10206366 0.5279446 1.603486 0.05728144 0.3144953 1.584652 0.42590417 0.30470000 0.3557000 0.0510000 8.804900e-01 3.501644e-19 FALSE TRUE
ENST00000415105 ENSG00000091129 HEK293_OSMI2_2hA HEK293_TMG_2hB NRCAM protein_coding retained_intron 2.618145 1.752464 4.561998 0.1922217 0.1620277 1.375231 0.03772094 0.1553524 0.000000 0.15535238 0.0000000 -4.047472 0.01866667 0.07940000 0.0000000 -0.0794000 6.045102e-01 3.501644e-19 FALSE FALSE
ENST00000522550 ENSG00000091129 HEK293_OSMI2_2hA HEK293_TMG_2hB NRCAM protein_coding processed_transcript 2.618145 1.752464 4.561998 0.1922217 0.1620277 1.375231 0.29693558 0.8014064 0.000000 0.02336635 0.0000000 -6.342353 0.20954583 0.46840000 0.0000000 -0.4684000 3.501644e-19 3.501644e-19   FALSE
MSTRG.30496.5 ENSG00000091129 HEK293_OSMI2_2hA HEK293_TMG_2hB NRCAM protein_coding   2.618145 1.752464 4.561998 0.1922217 0.1620277 1.375231 1.00487638 0.1380695 2.249661 0.08360301 0.3281409 3.931759 0.29457917 0.08036667 0.4930333 0.4126667 5.264175e-03 3.501644e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091129 E001 0.0000000       7 108147623 108147625 3 -      
ENSG00000091129 E002 0.4449813 0.0212840956 6.009943e-01 7.221652e-01 7 108147626 108147648 23 - 0.125 0.214 0.940
ENSG00000091129 E003 0.5901540 0.0200307162 8.426881e-01 9.019833e-01 7 108147649 108147661 13 - 0.176 0.214 0.355
ENSG00000091129 E004 15.6988500 0.0028402974 1.197817e-19 7.327181e-18 7 108147662 108147945 284 - 0.811 1.607 2.850
ENSG00000091129 E005 23.6584504 0.0062222038 2.080052e-23 1.925059e-21 7 108147946 108148116 171 - 0.984 1.770 2.745
ENSG00000091129 E006 136.5481940 0.0003565871 3.976456e-19 2.297431e-17 7 108148117 108149951 1835 - 1.985 2.261 0.922
ENSG00000091129 E007 17.1017361 0.0011676168 6.542224e-01 7.644653e-01 7 108149952 108150048 97 - 1.179 1.229 0.176
ENSG00000091129 E008 17.5315929 0.0021144508 7.350893e-01 8.259128e-01 7 108150049 108150147 99 - 1.203 1.177 -0.089
ENSG00000091129 E009 0.0000000       7 108150695 108150753 59 -      
ENSG00000091129 E010 0.0000000       7 108156387 108156448 62 -      
ENSG00000091129 E011 0.0000000       7 108156449 108156637 189 -      
ENSG00000091129 E012 15.7254676 0.0086190790 8.484692e-01 9.059191e-01 7 108159463 108159541 79 - 1.150 1.178 0.098
ENSG00000091129 E013 19.6977559 0.0306352515 7.129556e-01 8.095279e-01 7 108160361 108160492 132 - 1.234 1.280 0.160
ENSG00000091129 E014 1.2629112 0.0115941397 5.389853e-01 6.703110e-01 7 108166921 108167073 153 - 0.335 0.214 -0.865
ENSG00000091129 E015 0.7405115 0.3465135615 4.090445e-01 5.526516e-01 7 108168277 108168402 126 - 0.263 0.000 -11.902
ENSG00000091129 E016 0.1472490 0.0442095676 1.000000e+00   7 108175322 108175357 36 - 0.067 0.000 -10.396
ENSG00000091129 E017 27.0608103 0.0174857433 8.355095e-01 8.971280e-01 7 108176430 108176606 177 - 1.382 1.370 -0.043
ENSG00000091129 E018 0.0000000       7 108176707 108176773 67 -      
ENSG00000091129 E019 25.1340940 0.0111819045 1.314210e-01 2.361256e-01 7 108177990 108178112 123 - 1.382 1.244 -0.479
ENSG00000091129 E020 0.1482932 0.0415592035 1.161861e-01   7 108178113 108178114 2 - 0.000 0.214 11.871
ENSG00000091129 E021 27.9905845 0.0006796999 4.931050e-02 1.079407e-01 7 108180223 108180427 205 - 1.427 1.276 -0.527
ENSG00000091129 E022 22.8294041 0.0010576684 3.107295e-02 7.405256e-02 7 108181822 108181937 116 - 1.347 1.158 -0.665
ENSG00000091129 E023 29.6015176 0.0007397510 1.913021e-03 6.956162e-03 7 108182695 108182920 226 - 1.463 1.213 -0.874
ENSG00000091129 E024 14.6327928 0.0012463969 1.705248e-03 6.299192e-03 7 108184241 108184311 71 - 1.198 0.829 -1.364
ENSG00000091129 E025 22.1938135 0.0023625160 1.455671e-02 3.949254e-02 7 108184417 108184614 198 - 1.344 1.118 -0.799
ENSG00000091129 E026 15.8943437 0.0038822940 5.480175e-02 1.176554e-01 7 108189645 108189746 102 - 1.203 0.997 -0.743
ENSG00000091129 E027 0.1451727 0.0429150540 1.000000e+00   7 108191254 108191283 30 - 0.067 0.000 -10.403
ENSG00000091129 E028 17.4192958 0.0080471295 3.062882e-01 4.484395e-01 7 108191729 108191853 125 - 1.221 1.118 -0.365
ENSG00000091129 E029 22.1516406 0.0008542051 2.557075e-02 6.306042e-02 7 108194024 108194171 148 - 1.338 1.139 -0.702
ENSG00000091129 E030 22.0137530 0.0009210411 1.277075e-01 2.309649e-01 7 108194262 108194428 167 - 1.324 1.195 -0.454
ENSG00000091129 E031 16.8179294 0.0010940715 7.629096e-02 1.535655e-01 7 108195761 108195872 112 - 1.225 1.049 -0.628
ENSG00000091129 E032 8.0283401 0.0020799937 1.449066e-01 2.547216e-01 7 108197956 108197994 39 - 0.936 0.738 -0.775
ENSG00000091129 E033 11.8229505 0.0014711669 1.197284e-01 2.195865e-01 7 108197995 108198099 105 - 1.084 0.904 -0.665
ENSG00000091129 E034 0.1515154 0.0426794085 1.000000e+00   7 108207228 108207527 300 - 0.067 0.000 -10.405
ENSG00000091129 E035 11.1761038 0.0018077761 9.898846e-02 1.889306e-01 7 108207528 108207659 132 - 1.065 0.868 -0.736
ENSG00000091129 E036 15.3823847 0.0013702190 6.656368e-02 1.376624e-01 7 108209421 108209605 185 - 1.189 0.997 -0.694
ENSG00000091129 E037 18.9703458 0.0210385155 2.250191e-01 3.564373e-01 7 108223725 108223836 112 - 1.261 1.121 -0.497
ENSG00000091129 E038 8.7195929 0.0632774592 7.653712e-01 8.481604e-01 7 108225645 108225701 57 - 0.935 0.874 -0.234
ENSG00000091129 E039 20.8823109 0.0098178325 1.988908e-02 5.125203e-02 7 108226208 108226378 171 - 1.320 1.074 -0.874
ENSG00000091129 E040 16.4374186 0.0065647815 9.410423e-03 2.730801e-02 7 108231031 108231153 123 - 1.233 0.937 -1.073
ENSG00000091129 E041 13.8826522 0.0270433754 1.975958e-02 5.097699e-02 7 108232326 108232398 73 - 1.169 0.829 -1.258
ENSG00000091129 E042 9.0944194 0.0063278146 6.721083e-02 1.387146e-01 7 108232399 108232416 18 - 0.991 0.738 -0.978
ENSG00000091129 E043 16.7080914 0.0011874761 1.557000e-01 2.693560e-01 7 108232417 108232522 106 - 1.211 1.074 -0.494
ENSG00000091129 E044 11.6683132 0.0015622067 1.482750e-01 2.593265e-01 7 108234583 108234629 47 - 1.072 0.904 -0.621
ENSG00000091129 E045 11.8713390 0.0014223480 2.906253e-02 7.012787e-02 7 108234630 108234688 59 - 1.095 0.829 -0.997
ENSG00000091129 E046 0.2966881 0.0290785164 1.000000e+00   7 108237752 108237769 18 - 0.125 0.000 -11.427
ENSG00000091129 E047 16.9028375 0.0011149020 1.053300e-02 3.005097e-02 7 108239959 108240170 212 - 1.237 0.968 -0.972
ENSG00000091129 E048 0.0000000       7 108243047 108243240 194 -      
ENSG00000091129 E049 9.6759243 0.0208098078 5.487954e-01 6.786178e-01 7 108312665 108312731 67 - 0.983 0.905 -0.295
ENSG00000091129 E050 0.0000000       7 108313204 108313295 92 -      
ENSG00000091129 E051 0.0000000       7 108328421 108328655 235 -      
ENSG00000091129 E052 10.6936830 0.0017024058 4.243606e-01 5.673364e-01 7 108399436 108399593 158 - 1.026 0.937 -0.331
ENSG00000091129 E053 7.6490578 0.0022097868 5.539922e-01 6.830511e-01 7 108456243 108456436 194 - 0.854 0.937 0.317
ENSG00000091129 E054 0.1451727 0.0429150540 1.000000e+00   7 108456670 108456717 48 - 0.067 0.000 -10.403