ENSG00000091127

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356362 ENSG00000091127 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7 protein_coding protein_coding 21.60719 9.485202 34.56373 0.4200386 0.5867001 1.864405 8.4777925 3.58408232 13.806679 0.56182711 0.4095750 1.9427155 0.39807500 0.377933333 0.39930000 0.021366667 9.101579e-01 6.627788e-12 FALSE TRUE
ENST00000469408 ENSG00000091127 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7 protein_coding protein_coding 21.60719 9.485202 34.56373 0.4200386 0.5867001 1.864405 5.0430217 4.42014497 8.587440 0.30549627 0.6456433 0.9565532 0.26718750 0.466600000 0.24840000 -0.218200000 5.207210e-05 6.627788e-12 FALSE TRUE
ENST00000487277 ENSG00000091127 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7 protein_coding retained_intron 21.60719 9.485202 34.56373 0.4200386 0.5867001 1.864405 2.1460494 0.62317146 1.921202 0.31420229 0.0576204 1.6088312 0.10405000 0.063966667 0.05570000 -0.008266667 9.183497e-01 6.627788e-12   FALSE
MSTRG.30446.4 ENSG00000091127 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7 protein_coding   21.60719 9.485202 34.56373 0.4200386 0.5867001 1.864405 0.6575945 0.05006161 2.155952 0.05006161 0.8875902 5.1724145 0.02777917 0.005566667 0.06243333 0.056866667 4.638554e-02 6.627788e-12 TRUE TRUE
MSTRG.30446.5 ENSG00000091127 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7 protein_coding   21.60719 9.485202 34.56373 0.4200386 0.5867001 1.864405 1.1104615 0.59029981 1.681161 0.08144142 0.1386594 1.4942593 0.05724167 0.062333333 0.04880000 -0.013533333 6.362449e-01 6.627788e-12 TRUE TRUE
MSTRG.30446.7 ENSG00000091127 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7 protein_coding   21.60719 9.485202 34.56373 0.4200386 0.5867001 1.864405 1.8398242 0.01332991 2.248057 0.01332991 0.1927769 6.5967572 0.06519583 0.001466667 0.06510000 0.063633333 1.229670e-10 6.627788e-12 TRUE TRUE
MSTRG.30446.8 ENSG00000091127 HEK293_OSMI2_2hA HEK293_TMG_2hB PUS7 protein_coding   21.60719 9.485202 34.56373 0.4200386 0.5867001 1.864405 1.7549083 0.00000000 3.632101 0.00000000 0.6852520 8.5086272 0.05141667 0.000000000 0.10476667 0.104766667 6.627788e-12 6.627788e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091127 E001 0.0000000       7 105439661 105439858 198 -      
ENSG00000091127 E002 1.9658840 0.0084163539 8.732570e-01 0.922582741 7 105456503 105456510 8 - 0.455 0.434 -0.111
ENSG00000091127 E003 325.5459805 0.0108440103 1.896278e-05 0.000118258 7 105456511 105457320 810 - 2.389 2.624 0.784
ENSG00000091127 E004 138.7848103 0.0002780605 1.454068e-01 0.255414187 7 105457321 105457458 138 - 2.084 2.144 0.201
ENSG00000091127 E005 107.2287244 0.0002824017 9.756080e-02 0.186766232 7 105457459 105457554 96 - 1.969 2.042 0.247
ENSG00000091127 E006 72.3935516 0.0003357732 5.764070e-03 0.017992549 7 105457555 105457697 143 - 1.777 1.912 0.454
ENSG00000091127 E007 181.1693623 0.0009636055 5.782708e-02 0.122902582 7 105457698 105457926 229 - 2.191 2.263 0.239
ENSG00000091127 E008 142.0976881 0.0003430898 5.341812e-01 0.666282806 7 105459168 105459259 92 - 2.099 2.132 0.110
ENSG00000091127 E009 0.7425998 0.0620964789 4.917402e-01 0.629017266 7 105462214 105462427 214 - 0.192 0.330 1.032
ENSG00000091127 E010 170.5839508 0.0002495241 4.675501e-01 0.607063095 7 105462621 105462750 130 - 2.177 2.210 0.113
ENSG00000091127 E011 138.3669355 0.0003022124 1.453313e-01 0.255309462 7 105465313 105465414 102 - 2.079 2.139 0.202
ENSG00000091127 E012 116.9879538 0.0003935404 8.650477e-01 0.917045955 7 105468337 105468428 92 - 2.023 2.029 0.019
ENSG00000091127 E013 80.1247422 0.0004481114 9.701019e-01 0.985299743 7 105468429 105468463 35 - 1.860 1.870 0.035
ENSG00000091127 E014 4.6800131 0.0345791748 5.815266e-02 0.123460204 7 105470286 105470687 402 - 0.618 0.923 1.229
ENSG00000091127 E015 79.7066299 0.0003512722 1.003788e-01 0.191045448 7 105470688 105470760 73 - 1.880 1.817 -0.211
ENSG00000091127 E016 102.2624536 0.0004084311 1.170365e-01 0.215722893 7 105470761 105470848 88 - 1.981 1.930 -0.173
ENSG00000091127 E017 108.3005055 0.0002722122 7.437704e-01 0.832314776 7 105472132 105472193 62 - 1.993 1.992 -0.002
ENSG00000091127 E018 161.1065504 0.0002629714 1.919830e-01 0.316249658 7 105481052 105481177 126 - 2.172 2.143 -0.098
ENSG00000091127 E019 168.5145949 0.0002171748 7.644927e-02 0.153820087 7 105482312 105482440 129 - 2.195 2.151 -0.144
ENSG00000091127 E020 80.3711707 0.0003425738 2.956763e-01 0.436828818 7 105491540 105491548 9 - 1.874 1.839 -0.118
ENSG00000091127 E021 102.1491511 0.0002736776 2.137404e-01 0.342927018 7 105491549 105491585 37 - 1.979 1.941 -0.126
ENSG00000091127 E022 102.3723695 0.0002684260 4.987517e-01 0.635155582 7 105491586 105491617 32 - 1.973 1.958 -0.050
ENSG00000091127 E023 143.9405344 0.0002300759 7.709930e-03 0.023050217 7 105495142 105495253 112 - 2.136 2.058 -0.263
ENSG00000091127 E024 9.2689093 0.0345095053 7.013252e-01 0.800534985 7 105495254 105495347 94 - 0.979 0.929 -0.185
ENSG00000091127 E025 16.8810774 0.0017847594 2.139397e-02 0.054421250 7 105502277 105502419 143 - 1.145 1.356 0.745
ENSG00000091127 E026 179.1039034 0.0002165688 3.890713e-03 0.012838274 7 105502420 105502564 145 - 2.231 2.155 -0.253
ENSG00000091127 E027 160.7220511 0.0003332465 7.789569e-03 0.023250519 7 105505955 105506056 102 - 2.182 2.107 -0.250
ENSG00000091127 E028 132.6916412 0.0002952999 8.320653e-02 0.164592918 7 105506189 105506273 85 - 2.094 2.045 -0.165
ENSG00000091127 E029 299.6180093 0.0098106149 2.159731e-02 0.054845710 7 105508115 105508520 406 - 2.459 2.352 -0.359
ENSG00000091127 E030 30.5295429 0.0023542980 6.879406e-01 0.790169927 7 105508521 105508544 24 - 1.456 1.437 -0.066
ENSG00000091127 E031 85.5578138 0.0192565447 1.590042e-01 0.273796894 7 105522052 105522271 220 - 1.917 1.815 -0.344