ENSG00000091039

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393249 ENSG00000091039 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL8 protein_coding protein_coding 11.14066 1.157458 21.13066 0.2092026 0.5225214 4.178578 1.3832046 0.06274952 2.548866 0.06274952 0.5477282 5.136423 0.19191667 0.0694 0.12150000 0.05210000 5.191297e-01 6.114636e-13 FALSE TRUE
ENST00000393250 ENSG00000091039 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL8 protein_coding protein_coding 11.14066 1.157458 21.13066 0.2092026 0.5225214 4.178578 3.4032837 0.00000000 6.504213 0.00000000 0.0651061 9.347447 0.16646667 0.0000 0.30826667 0.30826667 6.114636e-13 6.114636e-13 FALSE TRUE
ENST00000553139 ENSG00000091039 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL8 protein_coding protein_coding 11.14066 1.157458 21.13066 0.2092026 0.5225214 4.178578 0.4053931 0.00000000 1.394228 0.00000000 0.8884733 7.133633 0.01924583 0.0000 0.06513333 0.06513333 6.607261e-01 6.114636e-13   FALSE
ENST00000611266 ENSG00000091039 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL8 protein_coding protein_coding 11.14066 1.157458 21.13066 0.2092026 0.5225214 4.178578 4.1765269 1.09470857 9.727332 0.25216892 0.5166417 3.139861 0.51057083 0.9306 0.45973333 -0.47086667 1.636090e-02 6.114636e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000091039 E001 0.1472490 0.0450622689 3.757645e-01   12 76351797 76351799 3 - 0.027 0.000 -6.884
ENSG00000091039 E002 413.6016753 0.1018743263 1.239935e-04 6.321196e-04 12 76351800 76353924 2125 - 2.166 2.867 2.337
ENSG00000091039 E003 315.2133355 0.0001952845 2.480174e-02 6.146883e-02 12 76353925 76355835 1911 - 2.104 2.373 0.898
ENSG00000091039 E004 87.7880510 0.0049005677 8.617720e-01 9.148890e-01 12 76355836 76356021 186 - 1.563 1.756 0.656
ENSG00000091039 E005 83.2355042 0.0005339358 3.868971e-01 5.310686e-01 12 76356626 76356728 103 - 1.544 1.657 0.384
ENSG00000091039 E006 82.0871017 0.0560223785 2.224708e-01 3.533344e-01 12 76358706 76358811 106 - 1.544 1.542 -0.007
ENSG00000091039 E007 37.8408613 0.0005479469 5.844435e-02 1.239669e-01 12 76369214 76369218 5 - 1.225 1.151 -0.263
ENSG00000091039 E008 71.7730357 0.0003742110 8.125157e-02 1.615082e-01 12 76369219 76369301 83 - 1.487 1.508 0.073
ENSG00000091039 E009 67.7293278 0.0003845852 1.466448e-01 2.571235e-01 12 76369637 76369712 76 - 1.462 1.508 0.160
ENSG00000091039 E010 41.6472414 0.0004992246 1.029527e-01 1.949667e-01 12 76369713 76369717 5 - 1.263 1.242 -0.076
ENSG00000091039 E011 77.1431789 0.0006476580 5.813317e-02 1.234257e-01 12 76369718 76369822 105 - 1.519 1.530 0.038
ENSG00000091039 E012 0.1472490 0.0450622689 3.757645e-01   12 76371212 76371447 236 - 0.027 0.000 -8.488
ENSG00000091039 E013 76.8169755 0.0021240184 3.055098e-01 4.476216e-01 12 76371448 76371584 137 - 1.514 1.607 0.316
ENSG00000091039 E014 0.2924217 0.0274234837 8.062036e-01   12 76371585 76371862 278 - 0.053 0.000 -9.651
ENSG00000091039 E015 72.2524312 0.0003349383 3.531363e-01 4.973876e-01 12 76373344 76373433 90 - 1.487 1.589 0.348
ENSG00000091039 E016 0.1515154 0.0438957935 3.753779e-01   12 76373434 76373489 56 - 0.027 0.000 -8.499
ENSG00000091039 E017 75.1037154 0.0003639791 1.753551e-01 2.951306e-01 12 76375273 76375370 98 - 1.506 1.570 0.220
ENSG00000091039 E018 81.4118322 0.0007174271 1.156771e-01 2.137892e-01 12 76378452 76378550 99 - 1.540 1.589 0.166
ENSG00000091039 E019 75.1577036 0.0003374349 4.474622e-02 9.974136e-02 12 76384254 76384350 97 - 1.509 1.508 -0.004
ENSG00000091039 E020 0.2966881 0.0269643931 8.056547e-01   12 76386030 76386167 138 - 0.053 0.000 -9.657
ENSG00000091039 E021 57.7547933 0.0008655992 1.626901e-01 2.786669e-01 12 76386168 76386266 99 - 1.397 1.436 0.134
ENSG00000091039 E022 47.0874181 0.0137585674 1.931077e-01 3.176714e-01 12 76386579 76386660 82 - 1.312 1.318 0.020
ENSG00000091039 E023 68.8569535 0.0009921486 8.234625e-02 1.632133e-01 12 76389645 76389829 185 - 1.470 1.486 0.053
ENSG00000091039 E024 0.5997190 0.1487055518 1.000000e+00 1.000000e+00 12 76389830 76389984 155 - 0.100 0.000 -10.005
ENSG00000091039 E025 0.2903454 0.3115067684 6.160702e-01   12 76390281 76390419 139 - 0.052 0.000 -8.767
ENSG00000091039 E026 112.8901648 0.0002623240 4.639255e-05 2.634729e-04 12 76390420 76390657 238 - 1.686 1.530 -0.530
ENSG00000091039 E027 92.3407889 0.0004613180 8.504012e-06 5.742095e-05 12 76392581 76392752 172 - 1.605 1.350 -0.876
ENSG00000091039 E028 66.6021656 0.0003915704 8.201277e-04 3.331276e-03 12 76394645 76394729 85 - 1.466 1.281 -0.642
ENSG00000091039 E029 0.2966881 0.0269643931 8.056547e-01   12 76394730 76394737 8 - 0.053 0.000 -9.657
ENSG00000091039 E030 80.8557845 0.0003094317 4.317741e-04 1.896596e-03 12 76397694 76397855 162 - 1.545 1.380 -0.566
ENSG00000091039 E031 42.9929268 0.0027229024 3.036638e-03 1.037348e-02 12 76397856 76397897 42 - 1.283 1.036 -0.881
ENSG00000091039 E032 31.4786633 0.0037522659 7.140281e-03 2.158836e-02 12 76399873 76399880 8 - 1.157 0.880 -1.020
ENSG00000091039 E033 52.1544258 0.0012291209 6.635986e-04 2.765498e-03 12 76399881 76399974 94 - 1.364 1.097 -0.941
ENSG00000091039 E034 29.8121580 0.0021743274 1.028035e-02 2.945792e-02 12 76402689 76402698 10 - 1.134 0.879 -0.941
ENSG00000091039 E035 40.8504466 0.0025319548 1.604393e-03 5.975336e-03 12 76402699 76402723 25 - 1.263 0.965 -1.076
ENSG00000091039 E036 40.8554160 0.0041599177 5.632890e-03 1.763829e-02 12 76402724 76402755 32 - 1.262 1.036 -0.808
ENSG00000091039 E037 33.4787646 0.0011108143 1.091346e-02 3.095465e-02 12 76402756 76402766 11 - 1.181 0.965 -0.786
ENSG00000091039 E038 53.0564184 0.0004486762 1.367235e-03 5.199819e-03 12 76410564 76410634 71 - 1.371 1.151 -0.774
ENSG00000091039 E039 0.1451727 0.0434012795 3.746815e-01   12 76422511 76423266 756 - 0.027 0.000 -8.503
ENSG00000091039 E040 50.5809157 0.0004532473 8.602785e-04 3.474400e-03 12 76450851 76450892 42 - 1.353 1.097 -0.903
ENSG00000091039 E041 42.6895031 0.0005021136 7.116379e-04 2.940279e-03 12 76450893 76450900 8 - 1.284 0.965 -1.149
ENSG00000091039 E042 58.5605228 0.0004113380 2.205412e-05 1.353665e-04 12 76450901 76450979 79 - 1.416 1.036 -1.345
ENSG00000091039 E043 24.0143341 0.0008785005 3.217412e-03 1.090704e-02 12 76450980 76450988 9 - 1.053 0.632 -1.649
ENSG00000091039 E044 9.7558942 0.0033292795 1.052958e-02 3.004438e-02 12 76459859 76459895 37 - 0.720 0.000 -14.237
ENSG00000091039 E045 0.0000000       12 76486035 76486108 74 -      
ENSG00000091039 E046 38.2026627 0.0041309970 9.171580e-04 3.674975e-03 12 76487510 76487549 40 - 1.240 0.879 -1.316
ENSG00000091039 E047 35.8092112 0.0071555828 7.333219e-03 2.208464e-02 12 76487550 76487618 69 - 1.211 0.964 -0.894
ENSG00000091039 E048 0.0000000       12 76534234 76534281 48 -      
ENSG00000091039 E049 0.1451727 0.0434012795 3.746815e-01   12 76537004 76537041 38 - 0.027 0.000 -8.503
ENSG00000091039 E050 0.1472490 0.0450622689 3.757645e-01   12 76537957 76537986 30 - 0.027 0.000 -8.488
ENSG00000091039 E051 49.4414007 0.0061579907 1.294749e-02 3.578977e-02 12 76559397 76559809 413 - 1.340 1.198 -0.496