ENSG00000090989

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346134 ENSG00000090989 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC1 protein_coding protein_coding 8.713692 3.45829 12.95178 0.3950753 0.4181269 1.901967 1.5269204 0.0000000 3.14992558 0.00000000 0.17074023 8.303747 0.13787917 0.0000000 0.2442000 0.2442000 4.805944e-17 4.805944e-17 FALSE TRUE
ENST00000349598 ENSG00000090989 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC1 protein_coding protein_coding 8.713692 3.45829 12.95178 0.3950753 0.4181269 1.901967 0.8946781 1.2911564 0.00000000 0.22343906 0.00000000 -7.023651 0.12103750 0.3911667 0.0000000 -0.3911667 1.896654e-13 4.805944e-17 FALSE TRUE
ENST00000381295 ENSG00000090989 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC1 protein_coding protein_coding 8.713692 3.45829 12.95178 0.3950753 0.4181269 1.901967 1.9528325 0.9860804 2.15441294 0.04237583 0.52645930 1.119642 0.21450000 0.2968333 0.1692333 -0.1276000 3.398523e-01 4.805944e-17 FALSE TRUE
ENST00000506936 ENSG00000090989 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC1 protein_coding retained_intron 8.713692 3.45829 12.95178 0.3950753 0.4181269 1.901967 0.3948136 0.9646767 0.04687438 0.62288612 0.04687438 -4.099073 0.09527917 0.2490000 0.0034000 -0.2456000 1.699017e-01 4.805944e-17   FALSE
MSTRG.24911.2 ENSG00000090989 HEK293_OSMI2_2hA HEK293_TMG_2hB EXOC1 protein_coding   8.713692 3.45829 12.95178 0.3950753 0.4181269 1.901967 3.4534171 0.0000000 6.62604108 0.00000000 1.02370623 9.374179 0.37391667 0.0000000 0.5078333 0.5078333 2.833436e-16 4.805944e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090989 E001 0.0000000       4 55853648 55853660 13 +      
ENSG00000090989 E002 1.2242146 0.0106897227 6.254735e-01 7.415845e-01 4 55853661 55853674 14 + 0.274 0.389 0.720
ENSG00000090989 E003 5.4483672 0.0108737981 2.662740e-01 4.044482e-01 4 55853675 55853738 64 + 0.755 0.590 -0.695
ENSG00000090989 E004 19.3015439 0.0009676369 9.882305e-02 1.886777e-01 4 55853739 55853797 59 + 1.237 1.100 -0.488
ENSG00000090989 E005 30.6517297 0.0006334626 9.605402e-03 2.779251e-02 4 55853798 55853953 156 + 1.434 1.247 -0.654
ENSG00000090989 E006 22.5351586 0.0011140755 1.338686e-01 2.395304e-01 4 55858314 55858338 25 + 1.298 1.190 -0.383
ENSG00000090989 E007 36.3431002 0.0006048847 2.064727e-03 7.425759e-03 4 55858339 55858447 109 + 1.509 1.297 -0.735
ENSG00000090989 E008 35.7477876 0.0006887833 3.025855e-03 1.034242e-02 4 55860411 55860541 131 + 1.501 1.297 -0.707
ENSG00000090989 E009 45.9419746 0.0020958493 1.470448e-02 3.982387e-02 4 55864227 55864386 160 + 1.596 1.455 -0.483
ENSG00000090989 E010 71.7992524 0.0015399722 1.030384e-02 2.951497e-02 4 55868336 55868523 188 + 1.780 1.669 -0.376
ENSG00000090989 E011 0.4482035 0.0268750620 7.073442e-01 8.052897e-01 4 55868524 55868753 230 + 0.158 0.000 -9.702
ENSG00000090989 E012 71.6249860 0.0015100728 1.785638e-01 2.993529e-01 4 55870678 55870905 228 + 1.765 1.726 -0.131
ENSG00000090989 E013 43.1422865 0.0005587043 8.988046e-02 1.749451e-01 4 55871101 55871233 133 + 1.559 1.477 -0.284
ENSG00000090989 E014 49.8415998 0.0007842058 8.887843e-01 9.328652e-01 4 55871849 55871958 110 + 1.600 1.626 0.090
ENSG00000090989 E015 59.9058259 0.0003930836 8.739211e-02 1.711869e-01 4 55877917 55878066 150 + 1.698 1.633 -0.219
ENSG00000090989 E016 0.9609376 0.1679070753 4.279663e-01 5.707796e-01 4 55882727 55883767 1041 + 0.200 0.390 1.309
ENSG00000090989 E017 0.5138669 0.0202728038 5.004801e-01 6.367274e-01 4 55883768 55883822 55 + 0.111 0.237 1.309
ENSG00000090989 E018 56.4808495 0.0004118854 4.690588e-01 6.083631e-01 4 55883823 55883928 106 + 1.662 1.655 -0.025
ENSG00000090989 E019 1.6326522 0.0102489451 7.291953e-02 1.481960e-01 4 55888810 55888887 78 + 0.417 0.000 -11.576
ENSG00000090989 E020 21.1578173 0.0142767186 6.854424e-01 7.881703e-01 4 55888888 55888932 45 + 1.255 1.245 -0.034
ENSG00000090989 E021 76.8030809 0.0003331575 8.649892e-02 1.698078e-01 4 55890223 55890386 164 + 1.801 1.748 -0.177
ENSG00000090989 E022 57.5596633 0.0004311830 1.980409e-01 3.237710e-01 4 55891315 55891422 108 + 1.674 1.633 -0.139
ENSG00000090989 E023 1.2899771 0.0123325556 2.209273e-02 5.586942e-02 4 55892615 55892634 20 + 0.158 0.591 2.725
ENSG00000090989 E024 49.6980480 0.0005214680 6.398340e-01 7.531615e-01 4 55892635 55892711 77 + 1.592 1.655 0.215
ENSG00000090989 E025 71.9408261 0.0093807923 5.952801e-01 7.173972e-01 4 55893552 55893780 229 + 1.748 1.819 0.240
ENSG00000090989 E026 68.5554380 0.0005802877 7.018893e-01 8.008506e-01 4 55896717 55896900 184 + 1.739 1.754 0.050
ENSG00000090989 E027 77.4346767 0.0003436667 6.690472e-01 7.759540e-01 4 55899685 55899884 200 + 1.783 1.839 0.189
ENSG00000090989 E028 1.1813402 0.0107197051 6.789053e-01 7.832588e-01 4 55900559 55900692 134 + 0.306 0.236 -0.502
ENSG00000090989 E029 0.4418608 0.0241706578 7.083224e-01 8.060159e-01 4 55902127 55902343 217 + 0.158 0.000 -9.701
ENSG00000090989 E030 82.8994347 0.0004029704 1.387296e-03 5.265225e-03 4 55902344 55902538 195 + 1.784 1.961 0.596
ENSG00000090989 E031 139.5046291 0.0145477825 4.048329e-08 4.447598e-07 4 55904343 55905086 744 + 1.948 2.317 1.235