ENSG00000090924

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-7 / 7
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC

ENST00000205135	ENSG00000090924	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PLEKHG2	protein_coding	protein_coding	7.703994	7.793247	7.209589	0.7267046	0.5122194	-0.1121579	0.4687254	1.0268810	0.6238563	0.19539972	0.04247533	-0.7100226	0.06249167	0.13723333	0.08676667	-0.05046667	0.527192741	0.003822032	FALSE
ENST00000425673	ENSG00000090924	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PLEKHG2	protein_coding	protein_coding	7.703994	7.793247	7.209589	0.7267046	0.5122194	-0.1121579	1.5287483	1.8138981	1.0662512	0.08870820	0.08671480	-0.7610103	0.19890833	0.23476667	0.15086667	-0.08390000	0.121812045	0.003822032	FALSE
ENST00000458508	ENSG00000090924	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PLEKHG2	protein_coding	protein_coding	7.703994	7.793247	7.209589	0.7267046	0.5122194	-0.1121579	1.5705174	1.9625660	1.3011072	0.20566225	0.11524418	-0.5892879	0.20134583	0.25143333	0.18010000	-0.07133333	0.100199531	0.003822032	FALSE
ENST00000474449	ENSG00000090924	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PLEKHG2	protein_coding	retained_intron	7.703994	7.793247	7.209589	0.7267046	0.5122194	-0.1121579	0.4730691	0.1803967	0.6629836	0.03637313	0.13690476	1.8215625	0.06447917	0.02276667	0.09176667	0.06900000	0.003822032	0.003822032	FALSE
ENST00000478523	ENSG00000090924	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PLEKHG2	protein_coding	retained_intron	7.703994	7.793247	7.209589	0.7267046	0.5122194	-0.1121579	0.6931922	0.2994518	0.7252618	0.04648356	0.25117924	1.2485432	0.08958333	0.03896667	0.10616667	0.06720000	0.421913652	0.003822032	FALSE
ENST00000594307	ENSG00000090924	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PLEKHG2	protein_coding	retained_intron	7.703994	7.793247	7.209589	0.7267046	0.5122194	-0.1121579	0.7839142	0.6287649	0.8207966	0.36638275	0.54470426	0.3792103	0.09875417	0.07776667	0.10480000	0.02703333	0.999241005	0.003822032
MSTRG.17132.2	ENSG00000090924	HEK293_OSMI2_2hA	HEK293_TMG_2hB	PLEKHG2	protein_coding		7.703994	7.793247	7.209589	0.7267046	0.5122194	-0.1121579	1.1750910	1.1576754	1.5738865	0.30463636	0.21600839	0.4398297	0.15666250	0.14380000	0.21640000	0.07260000	0.330676592	0.003822032	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 49
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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000090924	E001	10.8454814	0.0087200644	5.297730e-01	6.624986e-01	19	39412669	39412713	45	+	1.085	1.025	-0.218
ENSG00000090924	E002	38.8534021	0.0005886596	5.953470e-03	1.848508e-02	19	39412714	39413092	379	+	1.667	1.520	-0.501
ENSG00000090924	E003	14.1321592	0.0013553982	4.625818e-01	6.024414e-01	19	39413093	39413123	31	+	1.197	1.138	-0.211
ENSG00000090924	E004	12.8736161	0.0015865705	7.239464e-01	8.176362e-01	19	39413124	39413140	17	+	1.139	1.112	-0.095
ENSG00000090924	E005	12.4975230	0.0132524861	3.763559e-01	5.206889e-01	19	39413141	39413149	9	+	1.163	1.077	-0.311
ENSG00000090924	E006	30.8338685	0.0012694863	6.342742e-02	1.324016e-01	19	39413150	39413308	159	+	1.548	1.436	-0.382
ENSG00000090924	E007	24.1061592	0.0233988048	4.245016e-02	9.553516e-02	19	39413309	39413412	104	+	1.484	1.300	-0.640
ENSG00000090924	E008	0.0000000				19	39413528	39413606	79	+
ENSG00000090924	E009	0.2966881	0.0273975944	1.086822e-01		19	39413665	39413811	147	+	0.255	0.000	-11.659
ENSG00000090924	E010	1.1061078	0.0121989077	2.287227e-01	3.609219e-01	19	39413812	39413891	80	+	0.146	0.367	1.737
ENSG00000090924	E011	1.8790975	0.1526583547	6.230914e-01	7.397695e-01	19	39413892	39414064	173	+	0.342	0.467	0.688
ENSG00000090924	E012	29.0272332	0.0064409572	5.039666e-02	1.098714e-01	19	39414065	39414195	131	+	1.538	1.402	-0.466
ENSG00000090924	E013	0.2965864	0.2840963933	4.226650e-01		19	39414196	39414232	37	+	0.000	0.181	9.087
ENSG00000090924	E014	8.9997053	0.0058177881	9.264476e-01	9.576834e-01	19	39414989	39414991	3	+	0.972	0.990	0.066
ENSG00000090924	E015	36.8872587	0.0062784781	8.659015e-02	1.699481e-01	19	39414992	39415168	177	+	1.624	1.517	-0.364
ENSG00000090924	E016	19.9476582	0.0042563953	1.874785e-02	4.877804e-02	19	39415169	39415192	24	+	1.411	1.229	-0.635
ENSG00000090924	E017	24.8646414	0.0008090298	2.009500e-02	5.168888e-02	19	39415193	39415260	68	+	1.485	1.331	-0.530
ENSG00000090924	E018	28.6240599	0.0049137220	8.334754e-01	8.956935e-01	19	39415339	39415439	101	+	1.449	1.442	-0.022
ENSG00000090924	E019	26.4335470	0.0234932277	8.621583e-01	9.151248e-01	19	39416348	39416414	67	+	1.416	1.410	-0.022
ENSG00000090924	E020	21.4811116	0.0239127193	6.307895e-01	7.459174e-01	19	39416551	39416597	47	+	1.277	1.347	0.242
ENSG00000090924	E021	34.7695164	0.0378606035	7.673742e-01	8.496198e-01	19	39416850	39417000	151	+	1.511	1.543	0.109
ENSG00000090924	E022	36.4797536	0.0043417617	4.984279e-01	6.348798e-01	19	39417555	39417692	138	+	1.576	1.538	-0.130
ENSG00000090924	E023	4.6231721	0.0048960067	1.721717e-03	6.350866e-03	19	39417845	39417904	60	+	0.953	0.530	-1.739
ENSG00000090924	E024	40.6134189	0.0005196907	5.254732e-01	6.588481e-01	19	39417905	39418071	167	+	1.616	1.588	-0.095
ENSG00000090924	E025	23.1408839	0.0008670229	7.560388e-01	8.412139e-01	19	39418072	39418105	34	+	1.368	1.353	-0.054
ENSG00000090924	E026	37.7951201	0.0020853072	3.108407e-02	7.407032e-02	19	39418734	39418826	93	+	1.636	1.514	-0.416
ENSG00000090924	E027	37.8910828	0.0007053239	2.461370e-03	8.648141e-03	19	39418917	39419003	87	+	1.667	1.503	-0.562
ENSG00000090924	E028	24.6895912	0.0008790190	3.087421e-02	7.367182e-02	19	39420626	39420659	34	+	1.479	1.337	-0.492
ENSG00000090924	E029	31.8419933	0.0009753562	1.115294e-03	4.354591e-03	19	39420751	39420800	50	+	1.616	1.423	-0.661
ENSG00000090924	E030	35.6699294	0.0006541932	8.507905e-04	3.440629e-03	19	39420801	39420852	52	+	1.652	1.465	-0.640
ENSG00000090924	E031	16.4186887	0.0011319859	3.281917e-01	4.716762e-01	19	39420949	39420996	48	+	1.268	1.193	-0.265
ENSG00000090924	E032	2.3531390	0.0152626179	1.222182e-01	2.231057e-01	19	39421035	39421074	40	+	0.662	0.414	-1.173
ENSG00000090924	E033	24.8408095	0.0015044585	2.283695e-01	3.604769e-01	19	39421075	39421113	39	+	1.437	1.358	-0.272
ENSG00000090924	E034	28.7993575	0.0010443477	1.196454e-02	3.344517e-02	19	39421283	39421299	17	+	1.548	1.392	-0.537
ENSG00000090924	E035	4.2499839	0.0103049524	1.949345e-03	7.070062e-03	19	39421666	39422114	449	+	0.933	0.495	-1.835
ENSG00000090924	E036	60.6485256	0.0004898128	2.540601e-03	8.884836e-03	19	39422115	39422288	174	+	1.848	1.718	-0.437
ENSG00000090924	E037	155.4145983	0.0055008105	2.423559e-01	3.769558e-01	19	39422732	39423427	696	+	2.197	2.159	-0.128
ENSG00000090924	E038	63.4336669	0.0054422139	8.734212e-02	1.711065e-01	19	39423428	39423653	226	+	1.713	1.823	0.370
ENSG00000090924	E039	28.3546683	0.0050845899	5.690722e-01	6.956947e-01	19	39423733	39423761	29	+	1.411	1.462	0.177
ENSG00000090924	E040	134.2949054	0.0002675028	7.733200e-02	1.552088e-01	19	39423762	39424310	549	+	2.067	2.130	0.211
ENSG00000090924	E041	56.6174265	0.0008511751	7.532163e-02	1.520340e-01	19	39424311	39424387	77	+	1.678	1.774	0.324
ENSG00000090924	E042	47.3116694	0.0079943544	8.760629e-02	1.715054e-01	19	39424388	39424455	68	+	1.581	1.706	0.427
ENSG00000090924	E043	65.2645956	0.0005148249	1.651332e-01	2.818734e-01	19	39424456	39424562	107	+	1.755	1.825	0.238
ENSG00000090924	E044	87.7619591	0.0007605944	6.655338e-03	2.032882e-02	19	39424563	39424770	208	+	1.848	1.966	0.397
ENSG00000090924	E045	54.9379885	0.0089213251	4.212537e-04	1.855807e-03	19	39424771	39424882	112	+	1.548	1.800	0.856
ENSG00000090924	E046	96.7358922	0.0071502571	5.039255e-09	6.573516e-08	19	39424883	39425237	355	+	1.720	2.064	1.159
ENSG00000090924	E047	58.5633297	0.0081732962	5.554593e-05	3.093955e-04	19	39425238	39425417	180	+	1.558	1.836	0.946
ENSG00000090924	E048	38.6703737	0.0011170436	1.167170e-04	5.988270e-04	19	39425418	39425541	124	+	1.404	1.651	0.848
ENSG00000090924	E049	93.5121601	0.0108952933	8.543310e-01	9.098881e-01	19	39425542	39428415	2874	+	1.954	1.955	0.002

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000090924

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3