ENSG00000090924

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000205135 ENSG00000090924 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG2 protein_coding protein_coding 7.703994 7.793247 7.209589 0.7267046 0.5122194 -0.1121579 0.4687254 1.0268810 0.6238563 0.19539972 0.04247533 -0.7100226 0.06249167 0.13723333 0.08676667 -0.05046667 0.527192741 0.003822032 FALSE  
ENST00000425673 ENSG00000090924 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG2 protein_coding protein_coding 7.703994 7.793247 7.209589 0.7267046 0.5122194 -0.1121579 1.5287483 1.8138981 1.0662512 0.08870820 0.08671480 -0.7610103 0.19890833 0.23476667 0.15086667 -0.08390000 0.121812045 0.003822032 FALSE  
ENST00000458508 ENSG00000090924 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG2 protein_coding protein_coding 7.703994 7.793247 7.209589 0.7267046 0.5122194 -0.1121579 1.5705174 1.9625660 1.3011072 0.20566225 0.11524418 -0.5892879 0.20134583 0.25143333 0.18010000 -0.07133333 0.100199531 0.003822032 FALSE  
ENST00000474449 ENSG00000090924 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG2 protein_coding retained_intron 7.703994 7.793247 7.209589 0.7267046 0.5122194 -0.1121579 0.4730691 0.1803967 0.6629836 0.03637313 0.13690476 1.8215625 0.06447917 0.02276667 0.09176667 0.06900000 0.003822032 0.003822032 FALSE  
ENST00000478523 ENSG00000090924 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG2 protein_coding retained_intron 7.703994 7.793247 7.209589 0.7267046 0.5122194 -0.1121579 0.6931922 0.2994518 0.7252618 0.04648356 0.25117924 1.2485432 0.08958333 0.03896667 0.10616667 0.06720000 0.421913652 0.003822032 FALSE  
ENST00000594307 ENSG00000090924 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG2 protein_coding retained_intron 7.703994 7.793247 7.209589 0.7267046 0.5122194 -0.1121579 0.7839142 0.6287649 0.8207966 0.36638275 0.54470426 0.3792103 0.09875417 0.07776667 0.10480000 0.02703333 0.999241005 0.003822032    
MSTRG.17132.2 ENSG00000090924 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHG2 protein_coding   7.703994 7.793247 7.209589 0.7267046 0.5122194 -0.1121579 1.1750910 1.1576754 1.5738865 0.30463636 0.21600839 0.4398297 0.15666250 0.14380000 0.21640000 0.07260000 0.330676592 0.003822032 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090924 E001 10.8454814 0.0087200644 5.297730e-01 6.624986e-01 19 39412669 39412713 45 + 1.085 1.025 -0.218
ENSG00000090924 E002 38.8534021 0.0005886596 5.953470e-03 1.848508e-02 19 39412714 39413092 379 + 1.667 1.520 -0.501
ENSG00000090924 E003 14.1321592 0.0013553982 4.625818e-01 6.024414e-01 19 39413093 39413123 31 + 1.197 1.138 -0.211
ENSG00000090924 E004 12.8736161 0.0015865705 7.239464e-01 8.176362e-01 19 39413124 39413140 17 + 1.139 1.112 -0.095
ENSG00000090924 E005 12.4975230 0.0132524861 3.763559e-01 5.206889e-01 19 39413141 39413149 9 + 1.163 1.077 -0.311
ENSG00000090924 E006 30.8338685 0.0012694863 6.342742e-02 1.324016e-01 19 39413150 39413308 159 + 1.548 1.436 -0.382
ENSG00000090924 E007 24.1061592 0.0233988048 4.245016e-02 9.553516e-02 19 39413309 39413412 104 + 1.484 1.300 -0.640
ENSG00000090924 E008 0.0000000       19 39413528 39413606 79 +      
ENSG00000090924 E009 0.2966881 0.0273975944 1.086822e-01   19 39413665 39413811 147 + 0.255 0.000 -11.659
ENSG00000090924 E010 1.1061078 0.0121989077 2.287227e-01 3.609219e-01 19 39413812 39413891 80 + 0.146 0.367 1.737
ENSG00000090924 E011 1.8790975 0.1526583547 6.230914e-01 7.397695e-01 19 39413892 39414064 173 + 0.342 0.467 0.688
ENSG00000090924 E012 29.0272332 0.0064409572 5.039666e-02 1.098714e-01 19 39414065 39414195 131 + 1.538 1.402 -0.466
ENSG00000090924 E013 0.2965864 0.2840963933 4.226650e-01   19 39414196 39414232 37 + 0.000 0.181 9.087
ENSG00000090924 E014 8.9997053 0.0058177881 9.264476e-01 9.576834e-01 19 39414989 39414991 3 + 0.972 0.990 0.066
ENSG00000090924 E015 36.8872587 0.0062784781 8.659015e-02 1.699481e-01 19 39414992 39415168 177 + 1.624 1.517 -0.364
ENSG00000090924 E016 19.9476582 0.0042563953 1.874785e-02 4.877804e-02 19 39415169 39415192 24 + 1.411 1.229 -0.635
ENSG00000090924 E017 24.8646414 0.0008090298 2.009500e-02 5.168888e-02 19 39415193 39415260 68 + 1.485 1.331 -0.530
ENSG00000090924 E018 28.6240599 0.0049137220 8.334754e-01 8.956935e-01 19 39415339 39415439 101 + 1.449 1.442 -0.022
ENSG00000090924 E019 26.4335470 0.0234932277 8.621583e-01 9.151248e-01 19 39416348 39416414 67 + 1.416 1.410 -0.022
ENSG00000090924 E020 21.4811116 0.0239127193 6.307895e-01 7.459174e-01 19 39416551 39416597 47 + 1.277 1.347 0.242
ENSG00000090924 E021 34.7695164 0.0378606035 7.673742e-01 8.496198e-01 19 39416850 39417000 151 + 1.511 1.543 0.109
ENSG00000090924 E022 36.4797536 0.0043417617 4.984279e-01 6.348798e-01 19 39417555 39417692 138 + 1.576 1.538 -0.130
ENSG00000090924 E023 4.6231721 0.0048960067 1.721717e-03 6.350866e-03 19 39417845 39417904 60 + 0.953 0.530 -1.739
ENSG00000090924 E024 40.6134189 0.0005196907 5.254732e-01 6.588481e-01 19 39417905 39418071 167 + 1.616 1.588 -0.095
ENSG00000090924 E025 23.1408839 0.0008670229 7.560388e-01 8.412139e-01 19 39418072 39418105 34 + 1.368 1.353 -0.054
ENSG00000090924 E026 37.7951201 0.0020853072 3.108407e-02 7.407032e-02 19 39418734 39418826 93 + 1.636 1.514 -0.416
ENSG00000090924 E027 37.8910828 0.0007053239 2.461370e-03 8.648141e-03 19 39418917 39419003 87 + 1.667 1.503 -0.562
ENSG00000090924 E028 24.6895912 0.0008790190 3.087421e-02 7.367182e-02 19 39420626 39420659 34 + 1.479 1.337 -0.492
ENSG00000090924 E029 31.8419933 0.0009753562 1.115294e-03 4.354591e-03 19 39420751 39420800 50 + 1.616 1.423 -0.661
ENSG00000090924 E030 35.6699294 0.0006541932 8.507905e-04 3.440629e-03 19 39420801 39420852 52 + 1.652 1.465 -0.640
ENSG00000090924 E031 16.4186887 0.0011319859 3.281917e-01 4.716762e-01 19 39420949 39420996 48 + 1.268 1.193 -0.265
ENSG00000090924 E032 2.3531390 0.0152626179 1.222182e-01 2.231057e-01 19 39421035 39421074 40 + 0.662 0.414 -1.173
ENSG00000090924 E033 24.8408095 0.0015044585 2.283695e-01 3.604769e-01 19 39421075 39421113 39 + 1.437 1.358 -0.272
ENSG00000090924 E034 28.7993575 0.0010443477 1.196454e-02 3.344517e-02 19 39421283 39421299 17 + 1.548 1.392 -0.537
ENSG00000090924 E035 4.2499839 0.0103049524 1.949345e-03 7.070062e-03 19 39421666 39422114 449 + 0.933 0.495 -1.835
ENSG00000090924 E036 60.6485256 0.0004898128 2.540601e-03 8.884836e-03 19 39422115 39422288 174 + 1.848 1.718 -0.437
ENSG00000090924 E037 155.4145983 0.0055008105 2.423559e-01 3.769558e-01 19 39422732 39423427 696 + 2.197 2.159 -0.128
ENSG00000090924 E038 63.4336669 0.0054422139 8.734212e-02 1.711065e-01 19 39423428 39423653 226 + 1.713 1.823 0.370
ENSG00000090924 E039 28.3546683 0.0050845899 5.690722e-01 6.956947e-01 19 39423733 39423761 29 + 1.411 1.462 0.177
ENSG00000090924 E040 134.2949054 0.0002675028 7.733200e-02 1.552088e-01 19 39423762 39424310 549 + 2.067 2.130 0.211
ENSG00000090924 E041 56.6174265 0.0008511751 7.532163e-02 1.520340e-01 19 39424311 39424387 77 + 1.678 1.774 0.324
ENSG00000090924 E042 47.3116694 0.0079943544 8.760629e-02 1.715054e-01 19 39424388 39424455 68 + 1.581 1.706 0.427
ENSG00000090924 E043 65.2645956 0.0005148249 1.651332e-01 2.818734e-01 19 39424456 39424562 107 + 1.755 1.825 0.238
ENSG00000090924 E044 87.7619591 0.0007605944 6.655338e-03 2.032882e-02 19 39424563 39424770 208 + 1.848 1.966 0.397
ENSG00000090924 E045 54.9379885 0.0089213251 4.212537e-04 1.855807e-03 19 39424771 39424882 112 + 1.548 1.800 0.856
ENSG00000090924 E046 96.7358922 0.0071502571 5.039255e-09 6.573516e-08 19 39424883 39425237 355 + 1.720 2.064 1.159
ENSG00000090924 E047 58.5633297 0.0081732962 5.554593e-05 3.093955e-04 19 39425238 39425417 180 + 1.558 1.836 0.946
ENSG00000090924 E048 38.6703737 0.0011170436 1.167170e-04 5.988270e-04 19 39425418 39425541 124 + 1.404 1.651 0.848
ENSG00000090924 E049 93.5121601 0.0108952933 8.543310e-01 9.098881e-01 19 39425542 39428415 2874 + 1.954 1.955 0.002