ENSG00000090905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315183 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding protein_coding 15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 2.4712476 1.25067505 4.5220155 0.40034550 0.30005646 1.845956 0.14662500 0.121300000 0.216733333 0.09543333 1.730058e-01 4.034958e-32 FALSE TRUE
ENST00000450465 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding protein_coding 15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 1.7371363 3.01592221 0.0000000 0.43213239 0.00000000 -8.241231 0.15138333 0.294200000 0.000000000 -0.29420000 4.034958e-32 4.034958e-32 FALSE TRUE
ENST00000464539 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding retained_intron 15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 1.0244752 2.70107450 0.1280717 0.84112946 0.03393416 -4.295375 0.09332083 0.270566667 0.006066667 -0.26450000 2.866828e-08 4.034958e-32 FALSE TRUE
ENST00000567232 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding retained_intron 15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 0.3390556 0.00000000 1.0548462 0.00000000 0.20689350 6.734501 0.01695833 0.000000000 0.050533333 0.05053333 2.273048e-07 4.034958e-32 FALSE FALSE
ENST00000568903 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding retained_intron 15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 0.6703464 0.18419639 1.4937409 0.10717502 0.10814302 2.952968 0.04121250 0.017733333 0.071366667 0.05363333 7.173359e-03 4.034958e-32 FALSE TRUE
MSTRG.12298.13 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding   15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 0.6843699 0.01883878 1.4971815 0.01883878 0.53224873 5.707699 0.03588333 0.001766667 0.071000000 0.06923333 1.080844e-03 4.034958e-32 FALSE TRUE
MSTRG.12298.5 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding   15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 4.0788571 1.79497461 4.5626982 0.43967532 0.61722150 1.341067 0.25770000 0.173500000 0.219233333 0.04573333 7.238093e-01 4.034958e-32 FALSE TRUE
MSTRG.12298.7 ENSG00000090905 HEK293_OSMI2_2hA HEK293_TMG_2hB TNRC6A protein_coding   15.25808 10.19925 20.89288 0.3300974 0.370817 1.033825 1.7725317 0.35751949 3.8385739 0.18561439 0.25934860 3.388431 0.09762083 0.035300000 0.183433333 0.14813333 7.837940e-02 4.034958e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090905 E001 0.0000000       16 24610209 24610484 276 +      
ENSG00000090905 E002 0.0000000       16 24640884 24641009 126 +      
ENSG00000090905 E003 1.2660317 0.0396916427 7.109229e-01 8.079872e-01 16 24729651 24729694 44 + 0.343 0.313 -0.190
ENSG00000090905 E004 1.9938709 0.1594767541 3.006836e-01 4.424220e-01 16 24729695 24729711 17 + 0.506 0.314 -1.060
ENSG00000090905 E005 2.7301280 0.0938875056 5.082334e-01 6.436910e-01 16 24729712 24729712 1 + 0.581 0.491 -0.423
ENSG00000090905 E006 21.2724183 0.0008924592 1.041823e-03 4.103704e-03 16 24729713 24729846 134 + 1.371 1.168 -0.711
ENSG00000090905 E007 18.8693618 0.0009732860 6.541578e-07 5.653660e-06 16 24730253 24730300 48 + 1.359 0.950 -1.466
ENSG00000090905 E008 26.2270326 0.0007039084 5.625220e-08 5.993370e-07 16 24750726 24750813 88 + 1.490 1.119 -1.300
ENSG00000090905 E009 19.6530014 0.0016969409 8.173872e-07 6.917030e-06 16 24758339 24758360 22 + 1.374 0.975 -1.424
ENSG00000090905 E010 52.6672429 0.0188846874 8.671194e-07 7.298434e-06 16 24776933 24777247 315 + 1.781 1.424 -1.217
ENSG00000090905 E011 40.2369830 0.0472947401 9.188141e-04 3.680366e-03 16 24777248 24777358 111 + 1.659 1.351 -1.056
ENSG00000090905 E012 1.1845624 0.0107713434 2.805131e-02 6.811813e-02 16 24778344 24778468 125 + 0.416 0.000 -14.208
ENSG00000090905 E013 598.4254270 0.0108560812 1.819982e-06 1.428767e-05 16 24789232 24791486 2255 + 2.782 2.653 -0.431
ENSG00000090905 E014 114.7874102 0.0022304391 2.691458e-06 2.036052e-05 16 24791487 24791689 203 + 2.063 1.942 -0.407
ENSG00000090905 E015 87.4763024 0.0059215795 6.067020e-05 3.347640e-04 16 24791690 24791817 128 + 1.953 1.808 -0.490
ENSG00000090905 E016 2.6636228 0.0054785541 4.736582e-04 2.059327e-03 16 24793350 24793472 123 + 0.664 0.000 -15.378
ENSG00000090905 E017 36.5272868 0.0006682959 9.917572e-07 8.233728e-06 16 24793473 24793649 177 + 1.608 1.355 -0.869
ENSG00000090905 E018 106.8172115 0.0036216544 1.481536e-04 7.390594e-04 16 24794544 24794719 176 + 2.027 1.929 -0.329
ENSG00000090905 E019 3.8026934 0.0979784286 5.511055e-03 1.731632e-02 16 24795644 24795906 263 + 0.766 0.185 -3.185
ENSG00000090905 E020 47.5673653 0.0004865742 3.475637e-03 1.165438e-02 16 24795907 24795939 33 + 1.677 1.591 -0.292
ENSG00000090905 E021 11.5723958 0.0047786553 1.692852e-02 4.477629e-02 16 24795940 24796368 429 + 1.122 0.924 -0.728
ENSG00000090905 E022 2.3690230 0.0059865844 8.064051e-02 1.605547e-01 16 24797486 24797489 4 + 0.581 0.313 -1.413
ENSG00000090905 E023 86.5643012 0.0010047144 1.788620e-02 4.689362e-02 16 24797490 24797570 81 + 1.913 1.890 -0.077
ENSG00000090905 E024 70.5584033 0.0093004683 2.636658e-02 6.468034e-02 16 24797915 24797966 52 + 1.838 1.772 -0.222
ENSG00000090905 E025 0.6653823 0.0172671820 7.908862e-01 8.662752e-01 16 24797967 24798127 161 + 0.205 0.184 -0.188
ENSG00000090905 E026 0.1817044 0.0390175007 2.228517e-01   16 24803922 24804176 255 + 0.000 0.184 13.725
ENSG00000090905 E027 86.4735346 0.0003476256 4.087572e-02 9.266223e-02 16 24804177 24804319 143 + 1.907 1.901 -0.017
ENSG00000090905 E028 0.4396707 0.0265918961 2.893606e-01 4.300439e-01 16 24804334 24804699 366 + 0.205 0.000 -12.793
ENSG00000090905 E029 0.2924217 0.0272161775 5.110315e-01   16 24804700 24804704 5 + 0.147 0.000 -12.208
ENSG00000090905 E030 2.5421826 0.0411619792 1.602444e-02 4.279015e-02 16 24804705 24804851 147 + 0.624 0.184 -2.603
ENSG00000090905 E031 0.8856962 0.0163835180 9.197525e-01 9.533010e-01 16 24804852 24805013 162 + 0.256 0.313 0.393
ENSG00000090905 E032 71.0282994 0.0023786880 7.526813e-01 8.388033e-01 16 24805014 24805151 138 + 1.792 1.887 0.320
ENSG00000090905 E033 0.7416694 0.0236451905 5.775420e-01 7.027844e-01 16 24805152 24805604 453 + 0.256 0.184 -0.607
ENSG00000090905 E034 52.3070616 0.0004181091 9.229662e-01 9.554140e-01 16 24805605 24805673 69 + 1.664 1.747 0.282
ENSG00000090905 E035 57.3119321 0.0004347463 3.785324e-01 5.228304e-01 16 24805674 24805733 60 + 1.721 1.756 0.118
ENSG00000090905 E036 59.3521000 0.0006210440 6.683170e-01 7.753551e-01 16 24806206 24806283 78 + 1.729 1.787 0.195
ENSG00000090905 E037 70.9705081 0.0017233348 2.321132e-02 5.818325e-02 16 24806574 24806668 95 + 1.834 1.802 -0.109
ENSG00000090905 E038 65.4143300 0.0004061122 2.129163e-04 1.019341e-03 16 24806669 24806718 50 + 1.818 1.718 -0.340
ENSG00000090905 E039 74.0277918 0.0026543487 6.261744e-03 1.929865e-02 16 24806719 24806784 66 + 1.861 1.802 -0.200
ENSG00000090905 E040 95.6593513 0.0003645551 7.750768e-02 1.554593e-01 16 24809350 24809481 132 + 1.950 1.960 0.035
ENSG00000090905 E041 0.1515154 0.0432387309 1.000000e+00   16 24809482 24809509 28 + 0.079 0.000 -11.209
ENSG00000090905 E042 100.5935109 0.0015256009 9.052644e-01 9.436792e-01 16 24815147 24815305 159 + 1.950 2.026 0.254
ENSG00000090905 E043 2.0767136 0.0787684741 5.712570e-01 6.975822e-01 16 24815306 24815354 49 + 0.479 0.414 -0.334
ENSG00000090905 E044 4.0674734 0.0064514157 6.293268e-01 7.447176e-01 16 24815355 24815475 121 + 0.624 0.760 0.566
ENSG00000090905 E045 2.0357000 0.0102145461 9.650142e-01 9.819689e-01 16 24815476 24816347 872 + 0.448 0.493 0.225
ENSG00000090905 E046 5.1265316 0.0037276951 4.365069e-01 5.785797e-01 16 24816585 24816815 231 + 0.765 0.718 -0.188
ENSG00000090905 E047 100.0038140 0.0003482793 6.500035e-01 7.611117e-01 16 24816816 24816956 141 + 1.936 2.032 0.323
ENSG00000090905 E048 89.8732450 0.0029231263 4.403955e-01 5.820742e-01 16 24818593 24818678 86 + 1.909 1.952 0.144
ENSG00000090905 E049 59.3086228 0.0075322554 7.594186e-02 1.530153e-01 16 24818679 24818700 22 + 1.758 1.720 -0.130
ENSG00000090905 E050 140.5999190 0.0002795413 4.398396e-01 5.815748e-01 16 24820139 24820360 222 + 2.081 2.185 0.347
ENSG00000090905 E051 2.9771585 0.0697393217 7.002763e-01 7.997905e-01 16 24821790 24822076 287 + 0.582 0.560 -0.096
ENSG00000090905 E052 76.3240598 0.0004225379 7.799873e-03 2.327541e-02 16 24822077 24822147 71 + 1.782 1.973 0.641
ENSG00000090905 E053 104.6149530 0.0027780899 8.476894e-04 3.429552e-03 16 24822874 24823013 140 + 1.904 2.128 0.750
ENSG00000090905 E054 860.4826093 0.0162364249 2.158859e-12 5.013353e-11 16 24823432 24826227 2796 + 2.723 3.144 1.399
ENSG00000090905 E055 1.5939410 0.1325547386 5.287876e-01 6.616682e-01 16 24827501 24827632 132 + 0.416 0.315 -0.592