ENSG00000090889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374403 ENSG00000090889 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF4A protein_coding protein_coding 33.19099 26.63578 37.36811 3.178239 1.019277 0.4882867 30.248033 25.422781 33.212326 3.1666990 0.6285248 0.3854639 0.91582917 0.9531 0.8892333 -0.06386667 0.005027007 0.005027007 FALSE  
ENST00000485406 ENSG00000090889 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF4A protein_coding processed_transcript 33.19099 26.63578 37.36811 3.178239 1.019277 0.4882867 2.942952 1.212998 4.155785 0.2020296 0.4048655 1.7681670 0.08417083 0.0469 0.1107667 0.06386667 0.005047149 0.005027007 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090889 E001 35.22596 0.0190898102 1.336027e-05 8.619614e-05 X 70290104 70290111 8 + 1.704 1.336 -1.260
ENSG00000090889 E002 65.33234 0.0127271214 5.395357e-04 2.308190e-03 X 70290112 70290150 39 + 1.915 1.705 -0.709
ENSG00000090889 E003 30.52166 0.0109410038 9.856634e-04 3.909859e-03 X 70290151 70290335 185 + 1.600 1.353 -0.849
ENSG00000090889 E004 148.81012 0.0027826195 1.522052e-10 2.603595e-09 X 70290438 70290578 141 + 2.273 2.053 -0.736
ENSG00000090889 E005 138.20248 0.0008677893 2.377338e-11 4.660384e-10 X 70290691 70290805 115 + 2.230 2.039 -0.638
ENSG00000090889 E006 160.04787 0.0041467619 2.100957e-06 1.626762e-05 X 70296998 70297188 191 + 2.286 2.113 -0.579
ENSG00000090889 E007 123.10733 0.0004149833 6.866548e-12 1.469718e-10 X 70299113 70299202 90 + 2.183 1.988 -0.654
ENSG00000090889 E008 215.06677 0.0002182132 4.644032e-19 2.661656e-17 X 70301900 70302066 167 + 2.421 2.232 -0.632
ENSG00000090889 E009 163.50017 0.0002310719 1.429051e-13 3.972552e-12 X 70302304 70302398 95 + 2.298 2.121 -0.591
ENSG00000090889 E010 170.02544 0.0002462881 2.410576e-06 1.842328e-05 X 70329405 70329521 117 + 2.283 2.186 -0.326
ENSG00000090889 E011 213.60848 0.0001695371 2.703616e-10 4.430342e-09 X 70330157 70330332 176 + 2.392 2.271 -0.407
ENSG00000090889 E012 132.55133 0.0002454821 2.973926e-07 2.754749e-06 X 70333628 70333689 62 + 2.189 2.063 -0.422
ENSG00000090889 E013 172.20968 0.0001917865 8.640338e-04 3.487634e-03 X 70341799 70341931 133 + 2.271 2.213 -0.193
ENSG00000090889 E014 136.24662 0.0003031290 1.079677e-02 3.067836e-02 X 70343703 70343761 59 + 2.162 2.116 -0.156
ENSG00000090889 E015 155.65797 0.0002373472 4.863186e-03 1.555016e-02 X 70343877 70343982 106 + 2.223 2.175 -0.160
ENSG00000090889 E016 130.61067 0.0002682539 2.799353e-01 4.197335e-01 X 70352600 70352656 57 + 2.125 2.124 -0.003
ENSG00000090889 E017 251.22827 0.0005340752 6.902296e-05 3.753213e-04 X 70353622 70353807 186 + 2.435 2.368 -0.223
ENSG00000090889 E018 186.02013 0.0002390446 9.386715e-03 2.724798e-02 X 70374151 70374254 104 + 2.292 2.255 -0.122
ENSG00000090889 E019 247.39554 0.0007569298 5.043771e-04 2.176451e-03 X 70375204 70375348 145 + 2.425 2.366 -0.198
ENSG00000090889 E020 243.34581 0.0017866183 7.027644e-03 2.129675e-02 X 70376100 70376210 111 + 2.415 2.360 -0.183
ENSG00000090889 E021 206.96014 0.0003401366 2.294489e-02 5.763053e-02 X 70386618 70386701 84 + 2.333 2.306 -0.089
ENSG00000090889 E022 249.96342 0.0001777146 6.149642e-02 1.291552e-01 X 70387184 70387297 114 + 2.408 2.398 -0.034
ENSG00000090889 E023 307.81462 0.0001597846 3.819906e-01 5.262479e-01 X 70395671 70395826 156 + 2.469 2.520 0.167
ENSG00000090889 E024 238.76915 0.0001850233 2.098928e-02 5.356734e-02 X 70395949 70396049 101 + 2.341 2.426 0.286
ENSG00000090889 E025 267.80502 0.0006091545 1.454221e-03 5.487675e-03 X 70402566 70402695 130 + 2.377 2.485 0.360
ENSG00000090889 E026 317.60592 0.0025989008 1.311265e-01 2.357239e-01 X 70403864 70404034 171 + 2.467 2.541 0.247
ENSG00000090889 E027 242.94676 0.0002871474 3.910837e-02 8.938739e-02 X 70404715 70404822 108 + 2.350 2.431 0.269
ENSG00000090889 E028 232.45809 0.0002042516 2.409634e-05 1.467367e-04 X 70405828 70405905 78 + 2.306 2.438 0.440
ENSG00000090889 E029 284.44091 0.0010606625 4.360547e-04 1.913048e-03 X 70406259 70406354 96 + 2.397 2.519 0.408
ENSG00000090889 E030 422.37269 0.0010135546 1.145054e-05 7.506907e-05 X 70406893 70407075 183 + 2.563 2.692 0.428
ENSG00000090889 E031 283.53183 0.0024355219 1.986351e-08 2.317869e-07 X 70417888 70418004 117 + 2.344 2.551 0.690
ENSG00000090889 E032 305.29423 0.0045263873 3.200008e-06 2.379246e-05 X 70419661 70419783 123 + 2.374 2.584 0.700
ENSG00000090889 E033 818.52905 0.0036575952 4.848792e-17 2.163422e-15 X 70420062 70420886 825 + 2.757 3.035 0.924