ENSG00000090857

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000288050 ENSG00000090857 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPR protein_coding protein_coding 15.28588 14.31283 13.20158 0.840302 0.2428116 -0.1165142 1.140902 0.3875286 2.072215 0.1343629 0.4420823 2.3889884 0.07805417 0.02800000 0.1576667 0.12966667 1.958632e-03 8.259131e-05 FALSE TRUE
ENST00000398122 ENSG00000090857 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPR protein_coding protein_coding 15.28588 14.31283 13.20158 0.840302 0.2428116 -0.1165142 1.200595 0.5873930 1.799578 0.5873930 0.2752423 1.5989009 0.08258333 0.04406667 0.1371000 0.09303333 1.547954e-01 8.259131e-05 FALSE TRUE
ENST00000562100 ENSG00000090857 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPR protein_coding processed_transcript 15.28588 14.31283 13.20158 0.840302 0.2428116 -0.1165142 0.696752 0.7383504 0.000000 0.3799947 0.0000000 -6.2256421 0.04441250 0.05470000 0.0000000 -0.05470000 1.686727e-01 8.259131e-05 FALSE TRUE
ENST00000569042 ENSG00000090857 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPR protein_coding protein_coding 15.28588 14.31283 13.20158 0.840302 0.2428116 -0.1165142 4.842020 7.5517030 1.734878 0.5172178 0.4458843 -2.1155849 0.30118750 0.53343333 0.1314000 -0.40203333 8.259131e-05 8.259131e-05 FALSE TRUE
MSTRG.12917.2 ENSG00000090857 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPR protein_coding   15.28588 14.31283 13.20158 0.840302 0.2428116 -0.1165142 3.347978 1.9466097 3.409569 1.3730103 0.5344078 0.8054584 0.22267917 0.12626667 0.2573333 0.13106667 5.671247e-01 8.259131e-05 FALSE TRUE
MSTRG.12917.5 ENSG00000090857 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPR protein_coding   15.28588 14.31283 13.20158 0.840302 0.2428116 -0.1165142 1.190818 1.1902867 1.345166 0.3084885 0.3885825 0.1750910 0.08051250 0.08166667 0.1017333 0.02006667 8.668726e-01 8.259131e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090857 E001 0.2903454 0.3176801705 2.626126e-01   16 70114129 70114295 167 + 0.181 0.000 -34.091
ENSG00000090857 E002 0.2903454 0.3176801705 2.626126e-01   16 70114296 70114300 5 + 0.181 0.000 -34.101
ENSG00000090857 E003 1.1729211 0.1245600306 4.701180e-02 1.038484e-01 16 70114301 70114331 31 + 0.449 0.148 -2.159
ENSG00000090857 E004 1.3964426 0.0125825812 7.910647e-02 1.580853e-01 16 70114332 70114340 9 + 0.449 0.259 -1.152
ENSG00000090857 E005 1.7296624 0.0081333665 1.107257e-01 2.065993e-01 16 70114341 70114342 2 + 0.488 0.347 -0.759
ENSG00000090857 E006 2.9861423 0.0051281303 8.733508e-02 1.710952e-01 16 70114343 70114343 1 + 0.641 0.538 -0.460
ENSG00000090857 E007 10.3470508 0.0668949577 2.097030e-01 3.381965e-01 16 70114344 70114371 28 + 1.045 1.065 0.073
ENSG00000090857 E008 17.8779157 0.0380532367 1.925945e-02 4.989806e-02 16 70114372 70114440 69 + 1.299 1.239 -0.212
ENSG00000090857 E009 4.9048604 0.0036558081 1.811072e-04 8.827595e-04 16 70114821 70114869 49 + 0.889 0.538 -1.460
ENSG00000090857 E010 6.5529488 0.0318318927 8.027586e-03 2.385085e-02 16 70114870 70114930 61 + 0.943 0.743 -0.779
ENSG00000090857 E011 2.6047731 0.0079216877 9.181036e-01 9.522379e-01 16 70120131 70120460 330 + 0.488 0.630 0.656
ENSG00000090857 E012 51.8125195 0.0320713539 5.406247e-03 1.703135e-02 16 70120461 70120719 259 + 1.736 1.695 -0.141
ENSG00000090857 E013 51.4413974 0.0136210981 4.594614e-05 2.612274e-04 16 70127260 70127393 134 + 1.748 1.662 -0.292
ENSG00000090857 E014 40.5452802 0.0005899851 1.958792e-09 2.747370e-08 16 70128784 70128865 82 + 1.659 1.538 -0.413
ENSG00000090857 E015 1.5262013 0.0318453036 7.742667e-03 2.313166e-02 16 70128866 70128958 93 + 0.523 0.149 -2.515
ENSG00000090857 E016 54.5893656 0.0268472123 7.091052e-03 2.146587e-02 16 70128959 70129122 164 + 1.748 1.725 -0.077
ENSG00000090857 E017 37.6146680 0.0186083231 4.231764e-03 1.379023e-02 16 70130423 70130544 122 + 1.592 1.569 -0.079
ENSG00000090857 E018 25.5324231 0.0126683797 6.416213e-02 1.336293e-01 16 70131302 70131419 118 + 1.395 1.453 0.199
ENSG00000090857 E019 0.1515154 0.0426331605 4.694872e-01   16 70131933 70131985 53 + 0.100 0.000 -33.106
ENSG00000090857 E020 51.4475197 0.0278683923 5.616902e-02 1.199992e-01 16 70132151 70132300 150 + 1.692 1.742 0.171
ENSG00000090857 E021 54.6911774 0.0171487250 1.099316e-02 3.114619e-02 16 70136194 70136386 193 + 1.729 1.754 0.082
ENSG00000090857 E022 42.8641928 0.0063155341 9.337061e-05 4.907961e-04 16 70138899 70139023 125 + 1.651 1.611 -0.138
ENSG00000090857 E023 71.7917377 0.0027403706 3.010763e-07 2.785194e-06 16 70142234 70142389 156 + 1.868 1.839 -0.100
ENSG00000090857 E024 5.7959028 0.0029937355 1.059985e-01 1.996113e-01 16 70142471 70142552 82 + 0.843 0.827 -0.062
ENSG00000090857 E025 65.7018418 0.0003897170 8.864557e-08 9.087957e-07 16 70142553 70142686 134 + 1.825 1.808 -0.057
ENSG00000090857 E026 42.1009470 0.0031652181 1.846733e-03 6.748284e-03 16 70143510 70143658 149 + 1.612 1.640 0.094
ENSG00000090857 E027 31.3101748 0.0006716900 1.711454e-06 1.351351e-05 16 70144421 70144533 113 + 1.544 1.459 -0.291
ENSG00000090857 E028 0.0000000       16 70145727 70145748 22 +      
ENSG00000090857 E029 0.0000000       16 70145755 70145794 40 +      
ENSG00000090857 E030 0.0000000       16 70145795 70145797 3 +      
ENSG00000090857 E031 0.0000000       16 70145798 70145803 6 +      
ENSG00000090857 E032 0.0000000       16 70145804 70145833 30 +      
ENSG00000090857 E033 0.3729606 0.0302360769 9.743427e-01 9.879885e-01 16 70145834 70146133 300 + 0.100 0.149 0.658
ENSG00000090857 E034 46.0517255 0.0026236185 1.733936e-05 1.090745e-04 16 70146134 70146228 95 + 1.678 1.651 -0.094
ENSG00000090857 E035 0.9587465 0.0363384938 4.647982e-01 6.044950e-01 16 70147541 70147673 133 + 0.181 0.420 1.650
ENSG00000090857 E036 69.9786480 0.0078546785 1.984663e-04 9.572981e-04 16 70148464 70148553 90 + 1.849 1.846 -0.010
ENSG00000090857 E037 0.0000000       16 70148554 70148591 38 +      
ENSG00000090857 E038 89.4327233 0.0053336371 2.072005e-04 9.947925e-04 16 70153391 70153573 183 + 1.938 1.969 0.106
ENSG00000090857 E039 2284.9468084 0.0187487041 8.691764e-07 7.314123e-06 16 70156475 70162537 6063 + 3.191 3.505 1.043