ENSG00000090686

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308271 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding protein_coding 34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 2.030438 2.8248378 1.5349309 0.35209768 0.09112572 -0.8757239 0.07454583 0.15563333 0.0327000 -0.12293333 3.352420e-06 2.776708e-06 FALSE TRUE
ENST00000374732 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding protein_coding 34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 2.485763 0.9302807 3.6291650 0.07741717 0.28178723 1.9524440 0.07120000 0.05000000 0.0764000 0.02640000 4.083789e-02 2.776708e-06 FALSE TRUE
ENST00000421625 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding protein_coding 34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 3.390192 1.3415086 5.4452458 0.09719302 0.20907214 2.0130735 0.08905833 0.07303333 0.1156000 0.04256667 8.901087e-02 2.776708e-06 FALSE TRUE
ENST00000487880 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding processed_transcript 34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 2.506064 0.1794763 4.9968463 0.03486253 1.52961337 4.7238131 0.05674583 0.00960000 0.1038333 0.09423333 2.776708e-06 2.776708e-06 FALSE FALSE
ENST00000526044 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding protein_coding 34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 3.832729 1.1688443 4.3358849 1.16884433 0.67760929 1.8822767 0.10253750 0.05416667 0.0908000 0.03663333 2.298193e-01 2.776708e-06 FALSE FALSE
MSTRG.500.10 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding   34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 4.322328 6.5994407 0.9040504 0.48639760 0.90405036 -2.8541826 0.17962500 0.36013333 0.0183000 -0.34183333 1.492337e-02 2.776708e-06 FALSE TRUE
MSTRG.500.4 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding   34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 5.123124 2.1348985 9.6648512 0.51008566 0.82442463 2.1733301 0.13947917 0.11233333 0.2049333 0.09260000 1.133008e-01 2.776708e-06 FALSE TRUE
MSTRG.500.9 ENSG00000090686 HEK293_OSMI2_2hA HEK293_TMG_2hB USP48 protein_coding   34.51794 18.70723 47.3705 1.476872 2.389795 1.339926 7.929939 2.8137418 11.9622281 0.76554470 0.44721571 2.0840116 0.21286250 0.14766667 0.2529000 0.10523333 1.154912e-01 2.776708e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090686 E001 16.6288475 0.0339442509 2.535505e-04 1.189971e-03 1 21678298 21678902 605 - 1.009 1.472 1.640
ENSG00000090686 E002 79.0381453 0.0099200082 1.082314e-09 1.595030e-08 1 21678903 21679185 283 - 1.698 2.099 1.350
ENSG00000090686 E003 7.3706821 0.0033482661 9.646666e-03 2.789576e-02 1 21679186 21679190 5 - 0.756 1.075 1.209
ENSG00000090686 E004 23.2459226 0.0078300111 2.343072e-03 8.285821e-03 1 21679191 21679198 8 - 1.245 1.510 0.919
ENSG00000090686 E005 199.5756628 0.0043562143 2.206717e-10 3.666515e-09 1 21679199 21679366 168 - 2.167 2.438 0.904
ENSG00000090686 E006 179.8259042 0.0068288228 1.500667e-06 1.200172e-05 1 21679367 21679439 73 - 2.135 2.382 0.824
ENSG00000090686 E007 119.0705277 0.0033544287 5.287861e-10 8.247731e-09 1 21680808 21680834 27 - 1.940 2.219 0.935
ENSG00000090686 E008 3.6361981 0.0103736769 4.920178e-01 6.292403e-01 1 21680835 21681252 418 - 0.682 0.584 -0.426
ENSG00000090686 E009 3.4085119 0.0053862881 4.092991e-02 9.275400e-02 1 21685892 21687190 1299 - 0.721 0.383 -1.586
ENSG00000090686 E010 128.5413800 0.0006227925 7.149607e-17 3.133900e-15 1 21687191 21687239 49 - 1.968 2.258 0.969
ENSG00000090686 E011 173.4874119 0.0010808675 1.027764e-21 7.905270e-20 1 21689974 21690099 126 - 2.088 2.397 1.031
ENSG00000090686 E012 212.3303173 0.0002299854 2.726060e-19 1.606357e-17 1 21695066 21695221 156 - 2.212 2.450 0.794
ENSG00000090686 E013 203.8619091 0.0033618631 4.144678e-06 3.003239e-05 1 21701498 21701602 105 - 2.219 2.406 0.624
ENSG00000090686 E014 178.4335510 0.0085406984 3.110421e-03 1.059153e-02 1 21703512 21703618 107 - 2.168 2.341 0.576
ENSG00000090686 E015 202.3178748 0.0002303063 3.202015e-08 3.584966e-07 1 21704262 21704392 131 - 2.228 2.385 0.523
ENSG00000090686 E016 0.1515154 0.0430561321 1.000000e+00   1 21704393 21704615 223 - 0.088 0.000 -9.393
ENSG00000090686 E017 187.9309801 0.0018230653 6.876787e-05 3.741768e-04 1 21705727 21705837 111 - 2.200 2.346 0.486
ENSG00000090686 E018 144.2152959 0.0015257386 4.106875e-02 9.301188e-02 1 21706126 21706187 62 - 2.110 2.196 0.287
ENSG00000090686 E019 182.4158920 0.0011080168 4.114330e-01 5.549960e-01 1 21706467 21706589 123 - 2.229 2.269 0.133
ENSG00000090686 E020 159.5411489 0.0039106920 6.784100e-01 7.828846e-01 1 21706744 21706868 125 - 2.187 2.185 -0.009
ENSG00000090686 E021 0.4449813 0.0214903294 1.000000e+00 1.000000e+00 1 21706869 21706907 39 - 0.161 0.168 0.074
ENSG00000090686 E022 1.1039072 0.1715288954 8.866289e-01 9.314958e-01 1 21715124 21715388 265 - 0.326 0.289 -0.241
ENSG00000090686 E023 123.7570446 0.0020710685 3.297092e-01 4.732468e-01 1 21715389 21715457 69 - 2.085 2.060 -0.083
ENSG00000090686 E024 143.7085393 0.0064216848 6.796369e-01 7.837639e-01 1 21721036 21721163 128 - 2.144 2.137 -0.022
ENSG00000090686 E025 44.3961476 0.0004707229 4.892345e-01 6.266879e-01 1 21721164 21721166 3 - 1.619 1.671 0.176
ENSG00000090686 E026 138.7427456 0.0008051633 6.419483e-01 7.548881e-01 1 21721650 21721764 115 - 2.127 2.125 -0.005
ENSG00000090686 E027 118.5078015 0.0004274880 6.099890e-02 1.283151e-01 1 21723898 21723971 74 - 2.077 2.025 -0.173
ENSG00000090686 E028 148.0022545 0.0002811255 1.962960e-01 3.215899e-01 1 21723972 21724095 124 - 2.163 2.137 -0.086
ENSG00000090686 E029 44.6939927 0.0033827533 7.878192e-08 8.163767e-07 1 21724096 21724911 816 - 1.739 1.392 -1.186
ENSG00000090686 E030 17.5130474 0.0418639845 2.752438e-02 6.706121e-02 1 21724912 21725119 208 - 1.335 1.042 -1.044
ENSG00000090686 E031 13.1574536 0.0101791551 4.437521e-03 1.436486e-02 1 21726491 21726570 80 - 1.223 0.908 -1.146
ENSG00000090686 E032 82.8187593 0.0031374211 2.192175e-02 5.551261e-02 1 21727851 21728569 719 - 1.943 1.846 -0.325
ENSG00000090686 E033 132.7307605 0.0002310879 1.247554e-01 2.267861e-01 1 21728570 21728611 42 - 2.123 2.088 -0.118
ENSG00000090686 E034 189.1386247 0.0004499092 7.279505e-03 2.195044e-02 1 21728612 21728719 108 - 2.286 2.224 -0.206
ENSG00000090686 E035 218.4760573 0.0002923878 1.755160e-04 8.591318e-04 1 21729704 21729829 126 - 2.355 2.271 -0.279
ENSG00000090686 E036 85.8894474 0.0020742425 5.638987e-02 1.204072e-01 1 21729830 21729832 3 - 1.947 1.874 -0.245
ENSG00000090686 E037 0.0000000       1 21732664 21732761 98 -      
ENSG00000090686 E038 0.2944980 0.3654569255 5.824220e-01   1 21732762 21732836 75 - 0.161 0.000 -10.391
ENSG00000090686 E039 3.7268693 0.0041794122 7.629113e-02 1.535655e-01 1 21736430 21736445 16 - 0.739 0.461 -1.245
ENSG00000090686 E040 237.0875711 0.0001588009 5.121392e-08 5.509553e-07 1 21736446 21736625 180 - 2.401 2.280 -0.403
ENSG00000090686 E041 153.7547264 0.0022854723 1.811635e-08 2.128559e-07 1 21747067 21747149 83 - 2.237 2.031 -0.687
ENSG00000090686 E042 164.1482191 0.0074382766 1.616166e-05 1.024040e-04 1 21748138 21748271 134 - 2.265 2.057 -0.696
ENSG00000090686 E043 150.5281656 0.0018112475 2.029176e-05 1.256648e-04 1 21751507 21751615 109 - 2.209 2.065 -0.483
ENSG00000090686 E044 151.5740386 0.0002718216 1.321538e-08 1.592731e-07 1 21752527 21752651 125 - 2.218 2.051 -0.558
ENSG00000090686 E045 86.9284127 0.0072506251 3.496707e-05 2.044444e-04 1 21752992 21753006 15 - 1.998 1.763 -0.789
ENSG00000090686 E046 97.6508958 0.0014819792 4.885309e-10 7.660848e-09 1 21753007 21753034 28 - 2.056 1.795 -0.875
ENSG00000090686 E047 148.0217020 0.0033277515 2.944067e-11 5.677946e-10 1 21753035 21753119 85 - 2.238 1.963 -0.920
ENSG00000090686 E048 178.9045807 0.0002790680 4.045340e-19 2.333671e-17 1 21756546 21756702 157 - 2.315 2.059 -0.858
ENSG00000090686 E049 0.0000000       1 21757461 21757662 202 -      
ENSG00000090686 E050 126.3995191 0.0002404538 1.994809e-14 6.279672e-13 1 21757663 21757783 121 - 2.166 1.908 -0.865
ENSG00000090686 E051 0.5149111 0.0204421344 2.372666e-01 3.710108e-01 1 21781858 21782020 163 - 0.088 0.289 2.077
ENSG00000090686 E052 80.5813603 0.0003677576 5.898765e-09 7.604133e-08 1 21782824 21782891 68 - 1.968 1.724 -0.822
ENSG00000090686 E053 69.0872699 0.0004203841 3.132612e-08 3.511206e-07 1 21782892 21782977 86 - 1.904 1.653 -0.848
ENSG00000090686 E054 56.0627537 0.0049660312 4.631216e-06 3.322490e-05 1 21782978 21783606 629 - 1.821 1.545 -0.939