ENSG00000090661

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251363 ENSG00000090661 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS4 protein_coding protein_coding 12.3425 18.97716 9.708312 1.166073 0.1460699 -0.9662468 1.8682829 2.285017 1.0594765 0.6226609 0.05854581 -1.1016001 0.15508333 0.12146667 0.109300000 -0.012166667 0.99039375 0.02318342 FALSE  
ENST00000558877 ENSG00000090661 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS4 protein_coding protein_coding 12.3425 18.97716 9.708312 1.166073 0.1460699 -0.9662468 0.2320721 0.000000 0.5976538 0.0000000 0.32112677 5.9251778 0.02455000 0.00000000 0.062366667 0.062366667 0.12217721 0.02318342 FALSE  
ENST00000559450 ENSG00000090661 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS4 protein_coding protein_coding 12.3425 18.97716 9.708312 1.166073 0.1460699 -0.9662468 5.2810386 8.466640 5.1268595 0.3025581 0.42825025 -0.7226059 0.43182500 0.44773333 0.527200000 0.079466667 0.37655880 0.02318342 FALSE  
MSTRG.16341.12 ENSG00000090661 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS4 protein_coding   12.3425 18.97716 9.708312 1.166073 0.1460699 -0.9662468 0.7305667 1.629091 0.0772981 0.2368464 0.07729810 -4.2308023 0.05675000 0.08543333 0.008033333 -0.077400000 0.02318342 0.02318342 FALSE  
MSTRG.16341.7 ENSG00000090661 HEK293_OSMI2_2hA HEK293_TMG_2hB CERS4 protein_coding   12.3425 18.97716 9.708312 1.166073 0.1460699 -0.9662468 0.8594508 1.450004 0.7020637 0.3032645 0.38003520 -1.0358938 0.06479167 0.07496667 0.072533333 -0.002433333 0.86312152 0.02318342 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090661 E001 0.0000000       19 8206736 8206799 64 +      
ENSG00000090661 E002 0.0000000       19 8209303 8209312 10 +      
ENSG00000090661 E003 0.0000000       19 8209313 8209325 13 +      
ENSG00000090661 E004 0.1472490 0.0423473447 0.2240799370   19 8209326 8209339 14 + 0.171 0.000 -10.985
ENSG00000090661 E005 1.0308543 0.0142333739 0.3504373834 0.494608429 19 8209340 8209355 16 + 0.388 0.220 -1.125
ENSG00000090661 E006 1.2522995 0.0620678015 0.5490031756 0.678781699 19 8209356 8209356 1 + 0.388 0.276 -0.698
ENSG00000090661 E007 4.2945613 0.0185632464 0.5061736729 0.641846052 19 8209357 8209369 13 + 0.589 0.698 0.467
ENSG00000090661 E008 4.2945613 0.0185632464 0.5061736729 0.641846052 19 8209370 8209370 1 + 0.589 0.698 0.467
ENSG00000090661 E009 4.4460767 0.0059558118 0.7140566013 0.810373579 19 8209371 8209375 5 + 0.640 0.697 0.239
ENSG00000090661 E010 7.0290643 0.0024320055 0.8501935986 0.907086698 19 8209376 8209382 7 + 0.831 0.856 0.097
ENSG00000090661 E011 15.8800417 0.0222577976 0.7418879997 0.830929823 19 8209383 8209430 48 + 1.130 1.181 0.180
ENSG00000090661 E012 26.7892843 0.0034041632 0.8653536696 0.917264645 19 8209431 8209494 64 + 1.373 1.388 0.053
ENSG00000090661 E013 0.0000000       19 8209634 8209948 315 +      
ENSG00000090661 E014 0.3697384 0.0274424043 0.5090083513 0.644366594 19 8210683 8210705 23 + 0.000 0.159 11.930
ENSG00000090661 E015 32.6987322 0.0007944223 0.0424607947 0.095552298 19 8210706 8210862 157 + 1.364 1.506 0.490
ENSG00000090661 E016 0.6653823 0.0170541414 0.0766246665 0.154094446 19 8214366 8214481 116 + 0.388 0.087 -2.710
ENSG00000090661 E017 0.1817044 0.0397999070 1.0000000000   19 8214482 8214529 48 + 0.000 0.086 10.880
ENSG00000090661 E018 0.1817044 0.0397999070 1.0000000000   19 8225027 8225089 63 + 0.000 0.086 10.880
ENSG00000090661 E019 0.3268771 0.0286790506 0.5685446116   19 8240486 8240563 78 + 0.171 0.086 -1.126
ENSG00000090661 E020 9.8898084 0.0812550066 0.3542053378 0.498474477 19 8241341 8241457 117 + 0.859 1.023 0.615
ENSG00000090661 E021 2.4785904 0.0069889079 0.0249911398 0.061854883 19 8250526 8251043 518 + 0.727 0.366 -1.711
ENSG00000090661 E022 7.4544789 0.0033156844 0.6317327025 0.746699526 19 8251044 8251075 32 + 0.915 0.856 -0.225
ENSG00000090661 E023 35.7647226 0.0052718043 0.1777781931 0.298339493 19 8251076 8251109 34 + 1.575 1.483 -0.312
ENSG00000090661 E024 88.9901872 0.0067979480 0.6336682878 0.748321954 19 8251110 8251249 140 + 1.913 1.894 -0.065
ENSG00000090661 E025 123.0686976 0.0002492192 0.9148883828 0.950099544 19 8254499 8254616 118 + 2.036 2.041 0.015
ENSG00000090661 E026 127.0455936 0.0002997404 0.1863994422 0.309228750 19 8255607 8255725 119 + 2.084 2.041 -0.143
ENSG00000090661 E027 92.8616588 0.0004107723 0.0350495957 0.081744706 19 8255822 8255879 58 + 1.977 1.896 -0.270
ENSG00000090661 E028 3.7319592 0.0044013258 0.3525586824 0.496816294 19 8255880 8256235 356 + 0.727 0.587 -0.596
ENSG00000090661 E029 102.0708699 0.0007220839 0.0644111691 0.134056608 19 8256236 8256286 51 + 2.013 1.944 -0.229
ENSG00000090661 E030 127.0871692 0.0002781771 0.5389378833 0.670268525 19 8256618 8256710 93 + 2.070 2.050 -0.065
ENSG00000090661 E031 127.1870352 0.0021682362 0.9296754543 0.959706977 19 8256949 8257077 129 + 2.059 2.057 -0.006
ENSG00000090661 E032 1.5521212 0.0092343452 0.4190219775 0.562278344 19 8257078 8257161 84 + 0.466 0.323 -0.804
ENSG00000090661 E033 104.0499904 0.0003189082 0.7192146026 0.814116912 19 8257879 8257985 107 + 1.959 1.973 0.048
ENSG00000090661 E034 6.0786497 0.0028356963 0.7198734082 0.814599817 19 8260997 8261333 337 + 0.764 0.813 0.196
ENSG00000090661 E035 1.4414185 0.1497934317 0.4958653962 0.632606798 19 8261627 8261687 61 + 0.467 0.320 -0.822
ENSG00000090661 E036 126.7768678 0.0002856406 0.2076505997 0.335658010 19 8261688 8261844 157 + 2.023 2.066 0.145
ENSG00000090661 E037 164.5573503 0.0014640217 0.0004196356 0.001849582 19 8261930 8262421 492 + 2.077 2.198 0.407