ENSG00000090565

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000412256 ENSG00000090565 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP3 protein_coding protein_coding 41.16107 52.98545 33.97901 3.96893 0.5777284 -0.6408001 1.276246 3.553805 0.000000 0.2286152 0.00000000 -8.4772744 0.02721250 0.06773333 0.0000000 -0.06773333 1.660842e-28 9.06996e-43 FALSE  
ENST00000434585 ENSG00000090565 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP3 protein_coding protein_coding 41.16107 52.98545 33.97901 3.96893 0.5777284 -0.6408001 5.696807 9.082779 3.687323 0.4371680 0.21382856 -1.2982404 0.13630000 0.17296667 0.1085667 -0.06440000 7.348953e-03 9.06996e-43 FALSE  
ENST00000464263 ENSG00000090565 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP3 protein_coding retained_intron 41.16107 52.98545 33.97901 3.96893 0.5777284 -0.6408001 14.704017 18.583969 12.650344 0.6705504 0.39912001 -0.5545182 0.35867500 0.35303333 0.3724333 0.01940000 7.897412e-01 9.06996e-43 FALSE  
ENST00000487899 ENSG00000090565 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP3 protein_coding retained_intron 41.16107 52.98545 33.97901 3.96893 0.5777284 -0.6408001 3.960186 3.587546 3.005043 0.2021689 0.38387697 -0.2548347 0.09799167 0.06870000 0.0882000 0.01950000 5.153319e-01 9.06996e-43 FALSE  
MSTRG.11712.2 ENSG00000090565 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP3 protein_coding   41.16107 52.98545 33.97901 3.96893 0.5777284 -0.6408001 1.295306 0.000000 3.012029 0.0000000 0.22030356 8.2393736 0.03466667 0.00000000 0.0885000 0.08850000 9.069960e-43 9.06996e-43 FALSE  
MSTRG.11712.6 ENSG00000090565 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB11FIP3 protein_coding   41.16107 52.98545 33.97901 3.96893 0.5777284 -0.6408001 8.483660 11.751931 7.069047 1.8124904 0.04613112 -0.7324979 0.20521250 0.21923333 0.2081333 -0.01110000 9.150990e-01 9.06996e-43 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090565 E001 10.0151441 0.0360427661 2.899285e-01 4.306882e-01 16 425649 425755 107 + 1.078 0.958 -0.442
ENSG00000090565 E002 7.1868258 0.0023799314 6.786486e-02 1.398253e-01 16 425756 425767 12 + 1.002 0.802 -0.762
ENSG00000090565 E003 7.4029750 0.0022415563 1.234520e-02 3.436120e-02 16 425768 425781 14 + 1.060 0.786 -1.035
ENSG00000090565 E004 15.1065035 0.0171457660 2.451574e-12 5.643982e-11 16 425782 425999 218 + 1.542 0.818 -2.601
ENSG00000090565 E005 41.4087168 0.0121578861 2.152752e-09 2.998548e-08 16 426000 426360 361 + 1.834 1.409 -1.448
ENSG00000090565 E006 34.2469735 0.0149657406 1.987407e-02 5.122283e-02 16 426361 426378 18 + 1.608 1.439 -0.578
ENSG00000090565 E007 255.4085245 0.0079379266 4.390381e-03 1.423830e-02 16 426379 426720 342 + 2.433 2.328 -0.352
ENSG00000090565 E008 212.4255451 0.0006281165 7.467085e-04 3.066615e-03 16 461404 461497 94 + 2.326 2.255 -0.238
ENSG00000090565 E009 231.7912696 0.0003001280 2.201089e-04 1.049929e-03 16 471295 471389 95 + 2.364 2.292 -0.240
ENSG00000090565 E010 0.3289534 0.0285988593 5.536400e-01   16 474850 474868 19 + 0.169 0.087 -1.099
ENSG00000090565 E011 0.3289534 0.0285988593 5.536400e-01   16 474869 474923 55 + 0.169 0.087 -1.099
ENSG00000090565 E012 0.4031496 0.0243483327 5.236846e-01 6.573104e-01 16 474924 475045 122 + 0.000 0.160 11.176
ENSG00000090565 E013 0.2214452 0.0374076893 1.000000e+00   16 475046 475098 53 + 0.000 0.087 9.994
ENSG00000090565 E014 262.9792641 0.0018415383 9.151056e-03 2.665949e-02 16 482525 482656 132 + 2.408 2.354 -0.180
ENSG00000090565 E015 159.0600489 0.0002549672 5.366283e-01 6.683582e-01 16 482657 482736 80 + 2.149 2.152 0.010
ENSG00000090565 E016 167.6709110 0.0002897020 3.373182e-01 4.811861e-01 16 488851 488941 91 + 2.181 2.174 -0.023
ENSG00000090565 E017 152.8172326 0.0003679835 6.081846e-01 7.280008e-01 16 488942 489000 59 + 2.131 2.137 0.019
ENSG00000090565 E018 2.8871654 0.1579246043 8.963578e-02 1.745675e-01 16 489001 489101 101 + 0.762 0.416 -1.575
ENSG00000090565 E019 132.8381452 0.0017498007 3.405416e-02 7.986455e-02 16 491134 491268 135 + 2.117 2.060 -0.194
ENSG00000090565 E020 155.8157575 0.0002299492 2.138678e-02 5.440628e-02 16 496824 496859 36 + 2.179 2.131 -0.162
ENSG00000090565 E021 8.2521777 0.0038078884 8.058525e-03 2.392814e-02 16 496860 497158 299 + 1.111 0.831 -1.044
ENSG00000090565 E022 21.3316093 0.0043938198 5.182065e-01 6.524748e-01 16 497292 497448 157 + 1.322 1.290 -0.114
ENSG00000090565 E023 10.2993108 0.0232188842 3.756136e-01 5.200304e-01 16 502750 503003 254 + 1.078 0.992 -0.315
ENSG00000090565 E024 181.8994945 0.0002187522 2.534774e-02 6.258867e-02 16 503004 503097 94 + 2.240 2.199 -0.139
ENSG00000090565 E025 216.2777027 0.0001972576 6.659085e-01 7.734787e-01 16 505524 505627 104 + 2.277 2.288 0.036
ENSG00000090565 E026 0.6643356 0.7020633748 5.989973e-01 7.204984e-01 16 510453 510562 110 + 0.000 0.239 10.414
ENSG00000090565 E027 1.1426264 0.0117330284 7.136034e-02 1.455905e-01 16 510563 510659 97 + 0.000 0.368 12.986
ENSG00000090565 E028 288.8083302 0.0001855905 5.968536e-01 7.187214e-01 16 510660 510800 141 + 2.385 2.419 0.116
ENSG00000090565 E029 243.8456004 0.0002438145 3.979496e-01 5.416898e-01 16 518943 519024 82 + 2.338 2.339 0.004
ENSG00000090565 E030 26.1113725 0.0007861291 1.385487e-04 6.972223e-04 16 519025 519093 69 + 1.111 1.453 1.200
ENSG00000090565 E031 4.0169069 0.0040555966 7.546149e-02 1.522572e-01 16 519094 519108 15 + 0.827 0.590 -0.985
ENSG00000090565 E032 311.8751444 0.0003698218 9.515501e-01 9.736759e-01 16 519754 519891 138 + 2.429 2.451 0.071
ENSG00000090565 E033 240.3482618 0.0030040857 3.817299e-02 8.768317e-02 16 520122 520277 156 + 2.259 2.358 0.333
ENSG00000090565 E034 300.0166288 0.0001980837 5.371545e-02 1.157574e-01 16 520459 520599 141 + 2.376 2.443 0.224
ENSG00000090565 E035 1488.1453362 0.0023667160 6.824178e-10 1.044197e-08 16 520726 527407 6682 + 3.011 3.162 0.502