ENSG00000090539

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000204604 ENSG00000090539 HEK293_OSMI2_2hA HEK293_TMG_2hB CHRD protein_coding protein_coding 0.5903143 0.8122681 0.3374164 0.1736005 0.0278358 -1.242943 0.18159270 0.17734421 0.17715756 0.09042672 0.09260174 -0.001438069 0.32322083 0.21583333 0.48663333 0.2708000 0.7382901 0.032502 FALSE TRUE
ENST00000348986 ENSG00000090539 HEK293_OSMI2_2hA HEK293_TMG_2hB CHRD protein_coding protein_coding 0.5903143 0.8122681 0.3374164 0.1736005 0.0278358 -1.242943 0.06086649 0.21454921 0.00000000 0.11149675 0.00000000 -4.488959755 0.09083750 0.33863333 0.00000000 -0.3386333 0.3338000 0.032502 FALSE TRUE
ENST00000420973 ENSG00000090539 HEK293_OSMI2_2hA HEK293_TMG_2hB CHRD protein_coding nonsense_mediated_decay 0.5903143 0.8122681 0.3374164 0.1736005 0.0278358 -1.242943 0.02548469 0.00000000 0.08375554 0.00000000 0.08375554 3.228904006 0.07364167 0.00000000 0.29690000 0.2969000 0.7662391 0.032502 FALSE TRUE
ENST00000450923 ENSG00000090539 HEK293_OSMI2_2hA HEK293_TMG_2hB CHRD protein_coding protein_coding 0.5903143 0.8122681 0.3374164 0.1736005 0.0278358 -1.242943 0.11712022 0.22746717 0.00000000 0.12876254 0.00000000 -4.569656140 0.16784583 0.25740000 0.00000000 -0.2574000 0.3016467 0.032502 FALSE TRUE
ENST00000460627 ENSG00000090539 HEK293_OSMI2_2hA HEK293_TMG_2hB CHRD protein_coding retained_intron 0.5903143 0.8122681 0.3374164 0.1736005 0.0278358 -1.242943 0.04405535 0.00000000 0.04325325 0.00000000 0.00634780 2.412869693 0.08436667 0.00000000 0.12673333 0.1267333 0.0325020 0.032502 TRUE TRUE
ENST00000461684 ENSG00000090539 HEK293_OSMI2_2hA HEK293_TMG_2hB CHRD protein_coding retained_intron 0.5903143 0.8122681 0.3374164 0.1736005 0.0278358 -1.242943 0.02620824 0.07480739 0.00000000 0.07480739 0.00000000 -3.084189915 0.03496250 0.06460000 0.00000000 -0.0646000 0.8976401 0.032502   FALSE
ENST00000470150 ENSG00000090539 HEK293_OSMI2_2hA HEK293_TMG_2hB CHRD protein_coding retained_intron 0.5903143 0.8122681 0.3374164 0.1736005 0.0278358 -1.242943 0.04681888 0.09309790 0.03324999 0.06133595 0.03324999 -1.253243316 0.08266667 0.09526667 0.08976667 -0.0055000 0.9367687 0.032502 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090539 E001 0.1515154 0.041826969 0.212504815   3 184380073 184380206 134 + 0.177 0.000 -11.276
ENSG00000090539 E002 0.1472490 0.045995047 0.211424381   3 184380207 184380318 112 + 0.177 0.000 -14.056
ENSG00000090539 E003 0.1472490 0.045995047 0.211424381   3 184380319 184380320 2 + 0.177 0.000 -14.056
ENSG00000090539 E004 1.2470035 0.092493323 0.017765892 0.04663500 3 184380321 184380347 27 + 0.604 0.153 -2.838
ENSG00000090539 E005 1.5759569 0.109871784 0.026328215 0.06460464 3 184380348 184380451 104 + 0.655 0.213 -2.473
ENSG00000090539 E006 1.1383625 0.061783480 0.164344720 0.28083357 3 184380452 184380466 15 + 0.479 0.213 -1.670
ENSG00000090539 E007 0.1482932 0.042395762 1.000000000   3 184380623 184380691 69 + 0.000 0.083 11.196
ENSG00000090539 E008 2.1639434 0.016787606 0.974379143 0.98801178 3 184380692 184380795 104 + 0.479 0.461 -0.088
ENSG00000090539 E009 0.0000000       3 184380796 184380991 196 +      
ENSG00000090539 E010 0.0000000       3 184380992 184381018 27 +      
ENSG00000090539 E011 0.0000000       3 184381019 184381075 57 +      
ENSG00000090539 E012 0.0000000       3 184381076 184381079 4 +      
ENSG00000090539 E013 0.0000000       3 184381080 184381130 51 +      
ENSG00000090539 E014 0.4428904 0.216283805 0.605928864 0.72621993 3 184381131 184381160 30 + 0.000 0.156 11.988
ENSG00000090539 E015 0.4428904 0.216283805 0.605928864 0.72621993 3 184381161 184381234 74 + 0.000 0.156 11.988
ENSG00000090539 E016 2.4198439 0.036899160 0.467684033 0.60717454 3 184381235 184381364 130 + 0.399 0.521 0.619
ENSG00000090539 E017 0.0000000       3 184381406 184381495 90 +      
ENSG00000090539 E018 2.4378280 0.007987776 0.880128190 0.92711274 3 184381496 184381624 129 + 0.479 0.492 0.065
ENSG00000090539 E019 0.1515154 0.041826969 0.212504815   3 184381625 184381715 91 + 0.177 0.000 -14.061
ENSG00000090539 E020 1.4759479 0.032035369 0.682339504 0.78579479 3 184381716 184381749 34 + 0.400 0.314 -0.510
ENSG00000090539 E021 2.8775979 0.006473985 0.940353731 0.96655233 3 184381750 184381815 66 + 0.546 0.521 -0.117
ENSG00000090539 E022 0.0000000       3 184381816 184381890 75 +      
ENSG00000090539 E023 2.9516949 0.005746056 0.664173418 0.77203130 3 184381933 184381968 36 + 0.604 0.521 -0.382
ENSG00000090539 E024 4.2416720 0.004422584 0.454520005 0.59515383 3 184381969 184382020 52 + 0.743 0.619 -0.518
ENSG00000090539 E025 0.1451727 0.043882651 0.211859943   3 184382021 184382034 14 + 0.177 0.000 -14.058
ENSG00000090539 E026 0.1451727 0.043882651 0.211859943   3 184382035 184382042 8 + 0.177 0.000 -14.058
ENSG00000090539 E027 0.9578041 0.013021383 0.007517765 0.02255901 3 184382043 184382144 102 + 0.546 0.083 -3.578
ENSG00000090539 E028 0.4396707 0.071879693 0.016883539 0.04467603 3 184382145 184382173 29 + 0.399 0.000 -15.265
ENSG00000090539 E029 1.1802934 0.011812984 0.144404524 0.25402061 3 184382174 184382388 215 + 0.479 0.213 -1.671
ENSG00000090539 E030 6.5036709 0.028161926 0.917751564 0.95200813 3 184382389 184382530 142 + 0.815 0.815 -0.002
ENSG00000090539 E031 0.1515154 0.041826969 0.212504815   3 184382531 184382633 103 + 0.177 0.000 -14.061
ENSG00000090539 E032 5.6359471 0.003220097 0.911868548 0.94808606 3 184382634 184382747 114 + 0.780 0.751 -0.118
ENSG00000090539 E033 2.3959977 0.006451638 0.883341025 0.92938159 3 184382748 184382774 27 + 0.479 0.492 0.064
ENSG00000090539 E034 0.5244761 0.086043589 0.218885642 0.34905956 3 184382775 184382855 81 + 0.303 0.083 -2.251
ENSG00000090539 E035 2.9569924 0.005449023 0.934226623 0.96254714 3 184382856 184382884 29 + 0.546 0.547 0.006
ENSG00000090539 E036 3.8363589 0.004557949 0.371563745 0.51602232 3 184382885 184382930 46 + 0.743 0.596 -0.620
ENSG00000090539 E037 2.6550213 0.006469150 0.546780190 0.67688581 3 184382931 184382938 8 + 0.604 0.492 -0.521
ENSG00000090539 E038 0.8210624 0.028647847 0.653795785 0.76417839 3 184382939 184383015 77 + 0.303 0.212 -0.675
ENSG00000090539 E039 5.6745420 0.003100105 0.784166337 0.86154519 3 184383016 184383163 148 + 0.743 0.767 0.098
ENSG00000090539 E040 0.0000000       3 184383164 184383311 148 +      
ENSG00000090539 E041 4.7501241 0.010975085 0.425576477 0.56852065 3 184383312 184383418 107 + 0.604 0.719 0.487
ENSG00000090539 E042 4.8705070 0.023430296 0.719511207 0.81432172 3 184383523 184383642 120 + 0.743 0.684 -0.242
ENSG00000090539 E043 5.9795620 0.002924881 0.887664704 0.93219630 3 184384537 184384693 157 + 0.815 0.782 -0.132
ENSG00000090539 E044 0.1482932 0.042395762 1.000000000   3 184384788 184385017 230 + 0.000 0.083 11.196
ENSG00000090539 E045 8.3526283 0.002827185 0.247316416 0.38278570 3 184385018 184385238 221 + 0.815 0.944 0.493
ENSG00000090539 E046 4.1788994 0.040301202 0.380095152 0.52436109 3 184386046 184386159 114 + 0.546 0.699 0.668
ENSG00000090539 E047 0.3666179 0.027132092 0.541181933 0.67221326 3 184386160 184386491 332 + 0.177 0.083 -1.255
ENSG00000090539 E048 3.7298407 0.248731162 0.816350921 0.88379974 3 184386492 184386755 264 + 0.546 0.638 0.412
ENSG00000090539 E049 0.0000000       3 184386756 184386844 89 +      
ENSG00000090539 E050 6.1300031 0.003296782 0.199672831 0.32582170 3 184386845 184386938 94 + 0.655 0.825 0.692
ENSG00000090539 E051 4.8818707 0.004069008 0.289249162 0.42992689 3 184387051 184387107 57 + 0.604 0.751 0.617
ENSG00000090539 E052 2.3979723 0.007029966 0.162965900 0.27901097 3 184387374 184387401 28 + 0.302 0.547 1.326
ENSG00000090539 E053 2.5044483 0.034933531 0.139873903 0.24785285 3 184387402 184387477 76 + 0.302 0.570 1.433
ENSG00000090539 E054 4.4315037 0.037224975 0.038778199 0.08877305 3 184387931 184388033 103 + 0.400 0.764 1.669
ENSG00000090539 E055 5.3872445 0.007109010 0.504959438 0.64082107 3 184388587 184388741 155 + 0.701 0.781 0.325
ENSG00000090539 E056 6.7805626 0.002608581 0.511674997 0.64663682 3 184388893 184388995 103 + 0.780 0.852 0.279
ENSG00000090539 E057 2.7679142 0.005790175 0.543511205 0.67410320 3 184389367 184389369 3 + 0.604 0.492 -0.519
ENSG00000090539 E058 12.9055855 0.001703013 0.967981293 0.98398395 3 184389370 184389829 460 + 1.082 1.070 -0.043
ENSG00000090539 E059 0.0000000       3 184389830 184390736 907 +