ENSG00000090372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263280 ENSG00000090372 HEK293_OSMI2_2hA HEK293_TMG_2hB STRN4 protein_coding protein_coding 91.80356 134.0698 59.76836 8.077382 1.564672 -1.165397 42.766837 74.949383 26.116861 3.5538179 0.3438134 -1.5205753 0.4406125 0.56023333 0.43776667 -0.1224667 8.036597e-04 6.641779e-12 TRUE TRUE
ENST00000594581 ENSG00000090372 HEK293_OSMI2_2hA HEK293_TMG_2hB STRN4 protein_coding retained_intron 91.80356 134.0698 59.76836 8.077382 1.564672 -1.165397 4.639164 3.403967 3.127652 0.2679776 0.0956702 -0.1217640 0.0561500 0.02533333 0.05233333 0.0270000 1.672994e-08 6.641779e-12 TRUE TRUE
MSTRG.17380.8 ENSG00000090372 HEK293_OSMI2_2hA HEK293_TMG_2hB STRN4 protein_coding   91.80356 134.0698 59.76836 8.077382 1.564672 -1.165397 26.170086 33.908098 17.730331 3.5819619 0.4895682 -0.9350223 0.2982500 0.25173333 0.29673333 0.0450000 2.411384e-01 6.641779e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090372 E001 9.4986794 0.0282665798 2.851406e-01 4.254439e-01 19 46719511 46719512 2 - 0.837 1.000 0.616
ENSG00000090372 E002 756.5911595 0.0024003021 2.586352e-07 2.425026e-06 19 46719513 46719807 295 - 2.684 2.839 0.513
ENSG00000090372 E003 1151.2662972 0.0010202720 1.084160e-11 2.245690e-10 19 46719808 46720070 263 - 2.877 3.018 0.468
ENSG00000090372 E004 1190.4588879 0.0001182025 5.647861e-31 1.015152e-28 19 46720071 46720338 268 - 2.876 3.034 0.527
ENSG00000090372 E005 28.2998222 0.0035619132 5.130477e-01 6.478912e-01 19 46720339 46720408 70 - 1.350 1.405 0.193
ENSG00000090372 E006 36.6542098 0.0005958520 6.921077e-02 1.420643e-01 19 46720409 46720535 127 - 1.399 1.528 0.445
ENSG00000090372 E007 990.0474334 0.0007934427 1.412803e-09 2.037702e-08 19 46720536 46720698 163 - 2.827 2.948 0.402
ENSG00000090372 E008 738.2066032 0.0027469073 7.824425e-02 1.566481e-01 19 46720699 46720771 73 - 2.752 2.809 0.191
ENSG00000090372 E009 71.1933998 0.0040090570 1.492967e-14 4.799560e-13 19 46720772 46721752 981 - 2.050 1.653 -1.337
ENSG00000090372 E010 730.4666029 0.0034541835 8.219665e-01 8.877481e-01 19 46721986 46722072 87 - 2.782 2.795 0.043
ENSG00000090372 E011 24.2026334 0.0201225380 8.342543e-03 2.464786e-02 19 46722073 46722241 169 - 1.505 1.249 -0.890
ENSG00000090372 E012 839.5595453 0.0012363663 1.994920e-01 3.256011e-01 19 46722242 46722337 96 - 2.869 2.846 -0.075
ENSG00000090372 E013 458.8366513 0.0005613505 4.669512e-03 1.501008e-02 19 46722338 46722340 3 - 2.632 2.575 -0.190
ENSG00000090372 E014 567.0983587 0.0001627106 1.408013e-02 3.840493e-02 19 46722810 46722859 50 - 2.710 2.670 -0.133
ENSG00000090372 E015 605.7221043 0.0004640886 4.503000e-01 5.914144e-01 19 46722860 46722922 63 - 2.717 2.707 -0.034
ENSG00000090372 E016 416.1431895 0.0011625923 4.035780e-01 5.473464e-01 19 46722923 46722933 11 - 2.525 2.552 0.090
ENSG00000090372 E017 451.0576630 0.0004882817 7.840754e-01 8.614982e-01 19 46722934 46722950 17 - 2.571 2.582 0.033
ENSG00000090372 E018 13.1469995 0.0099619734 5.430750e-04 2.321179e-03 19 46722951 46723113 163 - 1.318 0.962 -1.276
ENSG00000090372 E019 783.8817794 0.0040129386 2.350855e-01 3.684430e-01 19 46723114 46723284 171 - 2.784 2.833 0.161
ENSG00000090372 E020 356.1680361 0.0025305299 1.914966e-01 3.156048e-01 19 46724807 46724827 21 - 2.439 2.490 0.168
ENSG00000090372 E021 653.2652480 0.0001034835 3.521139e-01 4.963646e-01 19 46724828 46724928 101 - 2.726 2.744 0.062
ENSG00000090372 E022 358.8178361 0.0002276799 6.870126e-01 7.894248e-01 19 46725332 46725332 1 - 2.487 2.482 -0.019
ENSG00000090372 E023 609.6306402 0.0001515123 9.292038e-01 9.594959e-01 19 46725333 46725379 47 - 2.709 2.711 0.006
ENSG00000090372 E024 453.9452938 0.0004658358 6.731375e-01 7.789144e-01 19 46725473 46725480 8 - 2.573 2.586 0.043
ENSG00000090372 E025 915.0841188 0.0006474478 3.247764e-01 4.681864e-01 19 46725481 46725632 152 - 2.896 2.884 -0.040
ENSG00000090372 E026 431.9386989 0.0009578523 9.896497e-01 9.975852e-01 19 46725633 46725648 16 - 2.558 2.562 0.015
ENSG00000090372 E027 64.9957169 0.0003627213 1.983141e-30 3.440477e-28 19 46725649 46726265 617 - 2.070 1.565 -1.706
ENSG00000090372 E028 356.1201471 0.0022506948 8.395641e-01 8.997732e-01 19 46727452 46727452 1 - 2.469 2.481 0.040
ENSG00000090372 E029 701.3778308 0.0005070347 1.001181e-01 1.906546e-01 19 46727453 46727546 94 - 2.791 2.765 -0.086
ENSG00000090372 E030 83.7102468 0.0011547388 3.345804e-01 4.783178e-01 19 46727547 46727567 21 - 1.886 1.844 -0.139
ENSG00000090372 E031 21.2095878 0.0012090451 2.512333e-11 4.904214e-10 19 46727568 46727691 124 - 1.596 1.097 -1.742
ENSG00000090372 E032 379.8658376 0.0010786953 3.488821e-01 4.931003e-01 19 46727894 46727906 13 - 2.521 2.501 -0.066
ENSG00000090372 E033 680.0890661 0.0017153532 3.219173e-01 4.651892e-01 19 46727907 46728007 101 - 2.774 2.755 -0.063
ENSG00000090372 E034 12.9458290 0.0560154527 1.114420e-02 3.151239e-02 19 46728008 46728126 119 - 1.338 0.957 -1.365
ENSG00000090372 E035 1.1707430 1.0130066853 4.787780e-01 6.172039e-01 19 46728127 46728299 173 - 0.561 0.189 -2.278
ENSG00000090372 E036 0.8010032 0.1348287483 1.609584e-01 2.763682e-01 19 46728300 46728406 107 - 0.415 0.145 -2.008
ENSG00000090372 E037 619.6716294 0.0018020417 4.332251e-01 5.756331e-01 19 46728618 46728684 67 - 2.732 2.716 -0.051
ENSG00000090372 E038 384.9980081 0.0011975504 7.010953e-02 1.435447e-01 19 46728685 46728686 2 - 2.546 2.503 -0.145
ENSG00000090372 E039 664.6020525 0.0012377620 1.681344e-01 2.857654e-01 19 46728687 46728777 91 - 2.771 2.744 -0.088
ENSG00000090372 E040 321.3358858 0.0021337836 1.578643e-01 2.722771e-01 19 46730732 46730732 1 - 2.466 2.427 -0.132
ENSG00000090372 E041 653.8190460 0.0001529507 3.695854e-02 8.538847e-02 19 46730733 46730835 103 - 2.765 2.734 -0.104
ENSG00000090372 E042 499.0588203 0.0001437508 6.715302e-03 2.048252e-02 19 46730836 46730873 38 - 2.659 2.611 -0.157
ENSG00000090372 E043 1.9467631 0.0136241390 5.020772e-01 6.381765e-01 19 46730874 46730931 58 - 0.316 0.445 0.741
ENSG00000090372 E044 1.3412721 0.0926724160 2.134977e-01 3.426537e-01 19 46731468 46731788 321 - 0.497 0.254 -1.430
ENSG00000090372 E045 470.4685028 0.0003193002 4.565524e-01 5.969651e-01 19 46733039 46733074 36 - 2.607 2.595 -0.039
ENSG00000090372 E046 449.9460166 0.0011465742 9.542659e-01 9.753433e-01 19 46733075 46733109 35 - 2.576 2.581 0.019
ENSG00000090372 E047 700.5484587 0.0001757143 7.186762e-01 8.136874e-01 19 46733110 46733199 90 - 2.763 2.772 0.031
ENSG00000090372 E048 539.5847237 0.0001513354 7.304318e-01 8.223918e-01 19 46733200 46733236 37 - 2.650 2.659 0.032
ENSG00000090372 E049 2.8129379 0.3193404855 8.044815e-01 8.756330e-01 19 46733237 46733449 213 - 0.416 0.545 0.642
ENSG00000090372 E050 4.3073631 0.0045131179 1.649123e-01 2.815902e-01 19 46733816 46733875 60 - 0.802 0.600 -0.844
ENSG00000090372 E051 1.0653228 0.0828204466 7.432049e-01 8.319277e-01 19 46736150 46736204 55 - 0.316 0.255 -0.419
ENSG00000090372 E052 1.1342230 0.1433415458 1.336418e-01 2.392060e-01 19 46736205 46736268 64 - 0.496 0.203 -1.837
ENSG00000090372 E053 0.0000000       19 46736269 46736349 81 -      
ENSG00000090372 E054 639.3031762 0.0011729769 5.076885e-01 6.431427e-01 19 46736823 46736901 79 - 2.741 2.731 -0.033
ENSG00000090372 E055 621.3463734 0.0004408034 1.094732e-03 4.286146e-03 19 46738164 46738237 74 - 2.762 2.706 -0.189
ENSG00000090372 E056 516.1075370 0.0002401290 7.583070e-09 9.554970e-08 19 46738785 46738888 104 - 2.714 2.611 -0.345
ENSG00000090372 E057 4.5706269 0.0036758058 5.477936e-02 1.176126e-01 19 46739310 46739386 77 - 0.870 0.599 -1.107
ENSG00000090372 E058 1.5039483 0.0123118879 2.686741e-01 4.071561e-01 19 46739387 46739507 121 - 0.496 0.299 -1.107
ENSG00000090372 E059 4.4358504 0.0113586896 2.490957e-02 6.168683e-02 19 46740164 46740285 122 - 0.900 0.577 -1.324
ENSG00000090372 E060 0.9953799 0.0122130541 2.360949e-01 3.696449e-01 19 46745757 46745830 74 - 0.415 0.203 -1.430
ENSG00000090372 E061 267.9071364 0.0023364507 5.174321e-13 1.328265e-11 19 46746149 46746211 63 - 2.519 2.288 -0.769
ENSG00000090372 E062 161.6054902 0.0077676896 1.519931e-10 2.600436e-09 19 46746212 46746763 552 - 2.360 2.036 -1.082
ENSG00000090372 E063 2.4733170 0.0058662881 2.789271e-01 4.186128e-01 19 46746764 46746801 38 - 0.624 0.445 -0.846
ENSG00000090372 E064 0.3697384 0.0274424043 6.397473e-01 7.530847e-01 19 46746802 46747475 674 - 0.000 0.145 9.070