ENSG00000090273

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321265 ENSG00000090273 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDC protein_coding protein_coding 233.1658 388.7832 175.2499 11.62363 2.774554 -1.149507 146.98864 282.19163 87.50247 19.78748 4.359335 -1.6891658 0.5912708 0.7244667 0.4990667 -0.2254000 0.0004279125 0.0004279125 FALSE TRUE
MSTRG.630.3 ENSG00000090273 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDC protein_coding   233.1658 388.7832 175.2499 11.62363 2.774554 -1.149507 73.15728 87.21902 75.49337 10.77029 2.853507 -0.2082671 0.3505500 0.2256000 0.4309333 0.2053333 0.0009454528 0.0004279125 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090273 E001 3.228325 0.0280231300 1.179694e-02 3.304737e-02 1 26900238 26900400 163 + 0.849 0.436 -1.807
ENSG00000090273 E002 9.878292 0.0018727278 1.868882e-02 4.865184e-02 1 26902282 26902366 85 + 1.153 0.899 -0.935
ENSG00000090273 E003 8.590567 0.0022456808 4.956103e-03 1.580938e-02 1 26911128 26911235 108 + 1.136 0.818 -1.185
ENSG00000090273 E004 82.769116 0.0120125422 1.897096e-02 4.927123e-02 1 26921728 26921742 15 + 1.963 1.799 -0.552
ENSG00000090273 E005 1932.147857 0.0053004027 4.152545e-04 1.832787e-03 1 26921743 26921929 187 + 3.303 3.175 -0.425
ENSG00000090273 E006 10.616700 0.0017105358 6.772909e-03 2.063272e-02 1 26922142 26922492 351 + 1.201 0.919 -1.027
ENSG00000090273 E007 1783.931365 0.0018167303 4.898981e-06 3.494605e-05 1 26924089 26924166 78 + 3.252 3.147 -0.348
ENSG00000090273 E008 78.573808 0.0037339531 1.028597e-01 1.948413e-01 1 26934249 26934419 171 + 1.893 1.806 -0.294
ENSG00000090273 E009 2939.097787 0.0009568652 6.635686e-05 3.624782e-04 1 26941457 26941660 204 + 3.440 3.374 -0.219
ENSG00000090273 E010 2047.855421 0.0002200515 6.829110e-04 2.836434e-03 1 26941753 26941818 66 + 3.264 3.225 -0.130
ENSG00000090273 E011 52.536978 0.0006350631 3.224810e-06 2.396182e-05 1 26942657 26942659 3 + 1.827 1.583 -0.826
ENSG00000090273 E012 2971.999651 0.0001345439 4.079620e-01 5.515549e-01 1 26942660 26942776 117 + 3.392 3.398 0.020
ENSG00000090273 E013 3973.953530 0.0001753773 1.235986e-04 6.303437e-04 1 26942871 26943065 195 + 3.499 3.529 0.100
ENSG00000090273 E014 41.756922 0.0041646670 1.862534e-07 1.795109e-06 1 26945135 26945389 255 + 1.786 1.455 -1.128
ENSG00000090273 E015 2728.592595 0.0006037895 3.720287e-04 1.666109e-03 1 26945390 26945473 84 + 3.322 3.368 0.152
ENSG00000090273 E016 32.044869 0.0053233616 9.165035e-02 1.777109e-01 1 26945474 26945567 94 + 1.539 1.411 -0.440
ENSG00000090273 E017 3283.636087 0.0012154598 5.689583e-05 3.160459e-04 1 26945568 26945686 119 + 3.386 3.452 0.220
ENSG00000090273 E018 33.354294 0.0112745628 1.201251e-03 4.644733e-03 1 26945930 26946129 200 + 1.649 1.387 -0.897
ENSG00000090273 E019 3223.978019 0.0012275199 6.157923e-09 7.904865e-08 1 26946130 26946871 742 + 3.353 3.450 0.323