ENSG00000090061

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389879 ENSG00000090061 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNK protein_coding protein_coding 46.83276 48.53809 46.42527 2.744348 0.8115815 -0.06419336 23.306194 32.27535383 17.09854 0.65476671 0.7744915 -0.9161633 0.49579583 0.6681000000 0.3679667 -0.3001333 4.024562e-10 5.734967e-17 FALSE TRUE
ENST00000555049 ENSG00000090061 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNK protein_coding protein_coding 46.83276 48.53809 46.42527 2.744348 0.8115815 -0.06419336 2.214257 0.03902148 4.61617 0.03902148 0.7247735 6.5602602 0.04756667 0.0008333333 0.1000333 0.0992000 5.734967e-17 5.734967e-17 FALSE TRUE
ENST00000557441 ENSG00000090061 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNK protein_coding protein_coding 46.83276 48.53809 46.42527 2.744348 0.8115815 -0.06419336 17.030281 14.31692180 18.19616 2.30434482 0.7961231 0.3456982 0.36237083 0.2916666667 0.3916667 0.1000000 9.695731e-02 5.734967e-17 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090061 E001 2.5400125 0.0066449504 9.668344e-01 9.832097e-01 14 99480991 99481164 174 + 0.512 0.549 0.175
ENSG00000090061 E002 0.7331366 0.0197907970 7.550499e-02 1.523165e-01 14 99481169 99481242 74 + 0.398 0.108 -2.412
ENSG00000090061 E003 5.7559293 0.0028808524 7.805054e-01 8.589526e-01 14 99481338 99481408 71 + 0.821 0.822 0.004
ENSG00000090061 E004 4.9852168 0.0033503718 7.575311e-01 8.423316e-01 14 99481409 99481411 3 + 0.769 0.763 -0.024
ENSG00000090061 E005 18.0227744 0.0234299034 2.034668e-01 3.305506e-01 14 99481412 99481423 12 + 1.321 1.222 -0.346
ENSG00000090061 E006 18.1408786 0.0228256813 1.771579e-01 2.975305e-01 14 99481424 99481424 1 + 1.328 1.221 -0.375
ENSG00000090061 E007 127.3886868 0.0004337177 1.945463e-06 1.517279e-05 14 99481425 99481449 25 + 2.158 2.047 -0.372
ENSG00000090061 E008 181.7893553 0.0013304394 3.038214e-04 1.394840e-03 14 99481450 99481479 30 + 2.289 2.220 -0.231
ENSG00000090061 E009 54.5621603 0.0020667192 9.653594e-01 9.822093e-01 14 99481480 99481614 135 + 1.707 1.747 0.136
ENSG00000090061 E010 7.8513200 0.0099663832 5.528066e-02 1.184781e-01 14 99491946 99492320 375 + 1.047 0.858 -0.708
ENSG00000090061 E011 520.6629792 0.0025546633 9.925376e-06 6.602605e-05 14 99492626 99492874 249 + 2.749 2.674 -0.249
ENSG00000090061 E012 1.6671195 0.0099648755 3.329807e-02 7.838536e-02 14 99492875 99493103 229 + 0.602 0.266 -1.827
ENSG00000090061 E013 339.8260627 0.0003483184 1.748889e-07 1.695442e-06 14 99493514 99493595 82 + 2.558 2.494 -0.213
ENSG00000090061 E014 3.4782368 0.0052176551 1.323846e-01 2.374045e-01 14 99493970 99495497 1528 + 0.741 0.549 -0.825
ENSG00000090061 E015 207.7686493 0.0001779506 1.505082e-03 5.652470e-03 14 99495498 99495504 7 + 2.329 2.293 -0.121
ENSG00000090061 E016 411.8080697 0.0001371180 1.343910e-07 1.332076e-06 14 99495505 99495629 125 + 2.633 2.583 -0.166
ENSG00000090061 E017 417.2334940 0.0001470952 6.808007e-07 5.859333e-06 14 99500766 99500871 106 + 2.634 2.590 -0.148
ENSG00000090061 E018 13.2012965 0.0016747256 4.768766e-18 2.421411e-16 14 99500872 99501355 484 + 1.464 0.642 -3.055
ENSG00000090061 E019 330.4382766 0.0001961625 1.028279e-03 4.056395e-03 14 99501356 99501413 58 + 2.521 2.498 -0.076
ENSG00000090061 E020 11.3632191 0.0014476963 5.393757e-15 1.846460e-13 14 99501414 99502206 793 + 1.392 0.613 -2.928
ENSG00000090061 E021 461.4916925 0.0001612758 2.430176e-01 3.777369e-01 14 99502207 99502376 170 + 2.638 2.661 0.078
ENSG00000090061 E022 432.4527974 0.0001314897 2.536493e-01 3.902117e-01 14 99502719 99502984 266 + 2.584 2.648 0.210
ENSG00000090061 E023 5.6360700 0.0156763801 3.741250e-03 1.241406e-02 14 99502985 99503610 626 + 1.000 0.642 -1.412
ENSG00000090061 E024 157.8718221 0.0002836311 2.781955e-02 6.765941e-02 14 99503611 99503644 34 + 2.117 2.225 0.362
ENSG00000090061 E025 196.4692097 0.0002274227 2.367161e-01 3.703824e-01 14 99507076 99507147 72 + 2.235 2.309 0.248
ENSG00000090061 E026 1462.9338242 0.0028508598 3.265639e-21 2.397928e-19 14 99510157 99512440 2284 + 2.982 3.233 0.837
ENSG00000090061 E027 0.4031496 0.0250561177 3.225329e-01 4.658297e-01 14 99534664 99535044 381 + 0.000 0.195 9.984