ENSG00000090060

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216277 ENSG00000090060 HEK293_OSMI2_2hA HEK293_TMG_2hB PAPOLA protein_coding protein_coding 50.67236 19.04462 77.34615 1.727447 2.669482 2.021375 26.1394636 7.523170 42.1048114 1.1316938 1.33337492 2.4829988 0.48280417 0.3999000 0.546966667 0.14706667 3.001914e-01 9.615389e-07 FALSE TRUE
ENST00000392990 ENSG00000090060 HEK293_OSMI2_2hA HEK293_TMG_2hB PAPOLA protein_coding protein_coding 50.67236 19.04462 77.34615 1.727447 2.669482 2.021375 9.7364481 1.765618 15.8212791 0.6263769 2.63323025 3.1563847 0.15322083 0.0914000 0.202766667 0.11136667 2.021463e-01 9.615389e-07 FALSE TRUE
ENST00000553940 ENSG00000090060 HEK293_OSMI2_2hA HEK293_TMG_2hB PAPOLA protein_coding retained_intron 50.67236 19.04462 77.34615 1.727447 2.669482 2.021375 0.6758777 1.874553 0.1682624 1.3509995 0.06182766 -3.4021480 0.02818333 0.0884000 0.002233333 -0.08616667 2.396344e-01 9.615389e-07   FALSE
ENST00000556459 ENSG00000090060 HEK293_OSMI2_2hA HEK293_TMG_2hB PAPOLA protein_coding protein_coding 50.67236 19.04462 77.34615 1.727447 2.669482 2.021375 4.5593492 4.172149 5.5514051 0.2933813 0.91332325 0.4112049 0.12544583 0.2212333 0.071200000 -0.15003333 9.615389e-07 9.615389e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090060 E001 0.0000000       14 96500742 96501432 691 +      
ENSG00000090060 E002 0.0000000       14 96501433 96501589 157 +      
ENSG00000090060 E003 1.1887151 0.0183419228 1.526090e-01 2.652220e-01 14 96501590 96502375 786 + 0.336 0.000 -16.819
ENSG00000090060 E004 0.5911862 0.0172671820 4.830484e-01 6.211334e-01 14 96502376 96502381 6 + 0.199 0.000 -16.887
ENSG00000090060 E005 2.2948123 0.0069332987 6.096792e-01 7.291232e-01 14 96502382 96502397 16 + 0.461 0.390 -0.380
ENSG00000090060 E006 3.1772743 0.0559435400 6.612183e-01 7.697179e-01 14 96502398 96502400 3 + 0.559 0.502 -0.268
ENSG00000090060 E007 4.3241696 0.0188233777 6.902378e-01 7.919828e-01 14 96502401 96502411 11 + 0.624 0.729 0.445
ENSG00000090060 E008 15.2564365 0.0184548994 1.880777e-01 3.113080e-01 14 96502412 96502440 29 + 1.072 1.266 0.692
ENSG00000090060 E009 55.4908255 0.0138793783 8.425774e-01 9.019037e-01 14 96502441 96502541 101 + 1.641 1.702 0.206
ENSG00000090060 E010 50.8474468 0.0073030780 3.306831e-01 4.742816e-01 14 96502542 96502557 16 + 1.590 1.704 0.386
ENSG00000090060 E011 119.1832654 0.0003819181 2.287202e-01 3.609209e-01 14 96502558 96502600 43 + 1.960 2.056 0.320
ENSG00000090060 E012 0.0000000       14 96502851 96502954 104 +      
ENSG00000090060 E013 0.9630009 0.0785354615 4.019189e-01 5.456237e-01 14 96504289 96504699 411 + 0.199 0.390 1.321
ENSG00000090060 E014 354.8501849 0.0001280490 2.574607e-01 3.945795e-01 14 96520055 96520228 174 + 2.436 2.509 0.245
ENSG00000090060 E015 0.7374030 0.0156342980 9.432138e-01 9.683835e-01 14 96520964 96521005 42 + 0.199 0.237 0.319
ENSG00000090060 E016 208.6850756 0.0013684331 9.645068e-01 9.816260e-01 14 96521006 96521015 10 + 2.211 2.259 0.160
ENSG00000090060 E017 273.7340124 0.0014997030 2.111389e-01 3.398613e-01 14 96521016 96521062 47 + 2.321 2.408 0.290
ENSG00000090060 E018 178.8766991 0.0002485598 1.127467e-02 3.181816e-02 14 96521063 96521072 10 + 2.128 2.257 0.430
ENSG00000090060 E019 299.8396684 0.0009123977 7.327668e-04 3.017246e-03 14 96525310 96525391 82 + 2.348 2.489 0.469
ENSG00000090060 E020 0.9650892 0.0161728074 1.050987e-02 3.000260e-02 14 96525981 96527429 1449 + 0.111 0.591 3.317
ENSG00000090060 E021 195.3735859 0.0004158915 2.080327e-01 3.361236e-01 14 96527430 96527441 12 + 2.176 2.263 0.292
ENSG00000090060 E022 334.5306158 0.0008267717 1.254552e-03 4.825220e-03 14 96527442 96527539 98 + 2.397 2.529 0.439
ENSG00000090060 E023 1.7078925 0.0079618012 9.937805e-01 1.000000e+00 14 96527540 96527952 413 + 0.364 0.390 0.150
ENSG00000090060 E024 271.1038860 0.0007624439 2.347563e-06 1.798523e-05 14 96527953 96528006 54 + 2.294 2.473 0.597
ENSG00000090060 E025 273.9248607 0.0005296076 4.921867e-09 6.432791e-08 14 96531475 96531586 112 + 2.292 2.495 0.678
ENSG00000090060 E026 18.2947803 0.0227353232 1.076913e-05 7.102698e-05 14 96531587 96532248 662 + 1.032 1.545 1.804
ENSG00000090060 E027 258.8777953 0.0001634636 4.459550e-03 1.442804e-02 14 96532331 96532420 90 + 2.289 2.412 0.411
ENSG00000090060 E028 286.1350583 0.0001671003 4.364612e-01 5.785331e-01 14 96532511 96532649 139 + 2.345 2.412 0.225
ENSG00000090060 E029 26.9867812 0.0196131940 2.274165e-02 5.721640e-02 14 96532650 96534222 1573 + 1.286 1.566 0.966
ENSG00000090060 E030 8.5033966 0.0019783665 6.669488e-01 7.743167e-01 14 96534223 96534490 268 + 0.895 0.878 -0.065
ENSG00000090060 E031 175.2600993 0.0002189140 2.089553e-12 4.865531e-11 14 96534491 96534563 73 + 2.181 1.960 -0.743
ENSG00000090060 E032 8.9526548 0.0019437255 4.321103e-01 5.745722e-01 14 96534564 96534889 326 + 0.878 1.019 0.528
ENSG00000090060 E033 4.5907705 0.0041813124 2.125535e-01 3.415637e-01 14 96535525 96535878 354 + 0.693 0.503 -0.850
ENSG00000090060 E034 246.4496647 0.0006565017 7.352674e-15 2.472825e-13 14 96535879 96535999 121 + 2.327 2.106 -0.737
ENSG00000090060 E035 0.4847352 0.2674295299 5.117513e-01 6.467068e-01 14 96536895 96536975 81 + 0.111 0.238 1.319
ENSG00000090060 E036 219.6141152 0.0003518978 7.469422e-15 2.508971e-13 14 96536976 96537060 85 + 2.278 2.053 -0.752
ENSG00000090060 E037 19.4168860 0.0009608992 2.345544e-06 1.797049e-05 14 96537061 96537901 841 + 1.092 1.528 1.526
ENSG00000090060 E038 1.9261181 0.0071545694 2.800890e-01 4.198874e-01 14 96541907 96542181 275 + 0.439 0.237 -1.266
ENSG00000090060 E039 0.9048261 0.4097688135 4.671368e-01 6.066386e-01 14 96542182 96542242 61 + 0.274 0.000 -17.330
ENSG00000090060 E040 185.7146718 0.0001940242 2.220681e-16 9.159620e-15 14 96542243 96542296 54 + 2.210 1.946 -0.887
ENSG00000090060 E041 1.2512830 0.0111518618 6.373542e-01 7.512595e-01 14 96542297 96542728 432 + 0.273 0.390 0.735
ENSG00000090060 E042 1.0976913 0.0535409935 5.132353e-01 6.480634e-01 14 96542729 96542773 45 + 0.237 0.390 1.001
ENSG00000090060 E043 235.0671797 0.0020355555 2.239394e-12 5.190829e-11 14 96542774 96542893 120 + 2.309 2.073 -0.790
ENSG00000090060 E044 224.3462954 0.0024993335 2.253723e-10 3.739368e-09 14 96544149 96544258 110 + 2.287 2.065 -0.741
ENSG00000090060 E045 0.6192988 0.0233942598 7.253650e-01 8.186624e-01 14 96547688 96547796 109 + 0.157 0.237 0.736
ENSG00000090060 E046 249.4418130 0.0001995843 3.281678e-15 1.160545e-13 14 96547797 96547895 99 + 2.331 2.127 -0.682
ENSG00000090060 E047 148.8023259 0.0002092636 4.699078e-09 6.162014e-08 14 96547896 96547918 23 + 2.107 1.916 -0.641
ENSG00000090060 E048 348.4438494 0.0001864052 1.128425e-23 1.078047e-21 14 96552480 96552622 143 + 2.478 2.250 -0.762
ENSG00000090060 E049 3.5566939 0.0044306583 3.819632e-02 8.771977e-02 14 96552623 96553532 910 + 0.638 0.237 -2.204
ENSG00000090060 E050 140.5793285 0.0021265966 1.017156e-09 1.506859e-08 14 96555847 96555849 3 + 2.089 1.837 -0.847
ENSG00000090060 E051 302.6666561 0.0025285997 3.838595e-12 8.552397e-11 14 96555850 96555947 98 + 2.416 2.196 -0.736
ENSG00000090060 E052 0.2987644 0.0275236306 1.000000e+00   14 96555948 96555950 3 + 0.111 0.000 -15.929
ENSG00000090060 E053 485.7295382 0.0009124358 1.767016e-10 2.988892e-09 14 96556175 96556413 239 + 2.606 2.488 -0.395
ENSG00000090060 E054 1.6681517 0.0080349403 9.935281e-01 1.000000e+00 14 96560438 96560648 211 + 0.364 0.390 0.149
ENSG00000090060 E055 184.8933758 0.0004207986 2.187088e-02 5.540898e-02 14 96560649 96560711 63 + 2.174 2.141 -0.109
ENSG00000090060 E056 5.1090321 0.0032580610 1.237345e-01 2.252699e-01 14 96562458 96562818 361 + 0.742 0.503 -1.050
ENSG00000090060 E057 212.9865539 0.0002061338 2.264886e-03 8.045374e-03 14 96562819 96562893 75 + 2.239 2.189 -0.168
ENSG00000090060 E058 2263.1832445 0.0023467651 1.770217e-16 7.381958e-15 14 96564955 96567116 2162 + 3.207 3.410 0.674