ENSG00000090054

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262554 ENSG00000090054 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTLC1 protein_coding protein_coding 37.96354 13.9373 56.99085 2.295193 0.4967169 2.030997 31.7270741 9.769199 46.953742 1.85112576 1.2485938 2.26375919 0.77273333 0.69620000 0.8239333 0.12773333 0.0759104043 3.421237e-06 FALSE TRUE
ENST00000337841 ENSG00000090054 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTLC1 protein_coding protein_coding 37.96354 13.9373 56.99085 2.295193 0.4967169 2.030997 2.5584560 1.858334 4.160700 0.34096630 0.3628992 1.15853682 0.09346250 0.13413333 0.0729000 -0.06123333 0.0112009092 3.421237e-06 FALSE TRUE
ENST00000692363 ENSG00000090054 HEK293_OSMI2_2hA HEK293_TMG_2hB SPTLC1 protein_coding protein_coding 37.96354 13.9373 56.99085 2.295193 0.4967169 2.030997 0.8153325 1.150181 1.121099 0.08982034 0.1330007 -0.03662463 0.04319167 0.08843333 0.0197000 -0.06873333 0.0001312229 3.421237e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090054 E001 0.1451727 0.0443825138 1.000000e+00   9 92000087 92000246 160 - 0.064 0.000 -8.321
ENSG00000090054 E002 0.2987644 0.0274696051 1.000000e+00   9 92000499 92000712 214 - 0.121 0.000 -11.222
ENSG00000090054 E003 0.1451727 0.0443825138 1.000000e+00   9 92000942 92001301 360 - 0.064 0.000 -10.197
ENSG00000090054 E004 0.0000000       9 92001302 92001406 105 -      
ENSG00000090054 E005 0.5954526 0.0172671820 4.107711e-01 5.543597e-01 9 92028458 92028639 182 - 0.215 0.000 -12.213
ENSG00000090054 E006 0.1472490 0.0449803356 1.000000e+00   9 92028640 92028737 98 - 0.064 0.000 -10.196
ENSG00000090054 E007 0.1472490 0.0449803356 1.000000e+00   9 92028738 92028757 20 - 0.064 0.000 -10.196
ENSG00000090054 E008 0.4396707 0.0318101097 6.144389e-01 7.329186e-01 9 92029180 92029249 70 - 0.170 0.000 -11.794
ENSG00000090054 E009 0.7394793 0.0153787590 1.000000e+00 1.000000e+00 9 92029250 92029346 97 - 0.215 0.220 0.045
ENSG00000090054 E010 0.4782907 0.0217681645 4.258489e-03 1.386563e-02 9 92031143 92031145 3 - 0.000 0.474 14.555
ENSG00000090054 E011 1.1007100 0.0124363092 4.637698e-03 1.492488e-02 9 92031146 92031146 1 - 0.121 0.634 3.366
ENSG00000090054 E012 6.7187532 0.0026198672 2.328145e-09 3.225066e-08 9 92031147 92031157 11 - 0.532 1.275 2.892
ENSG00000090054 E013 6.7187532 0.0026198672 2.328145e-09 3.225066e-08 9 92031158 92031159 2 - 0.532 1.275 2.892
ENSG00000090054 E014 6.8639259 0.0024877695 4.911206e-09 6.419743e-08 9 92031160 92031167 8 - 0.552 1.275 2.799
ENSG00000090054 E015 107.5414313 0.0013781079 2.205211e-32 4.397585e-30 9 92031168 92031271 104 - 1.798 2.291 1.655
ENSG00000090054 E016 374.4995847 0.0055434091 1.472520e-19 8.952649e-18 9 92031272 92031714 443 - 2.379 2.765 1.287
ENSG00000090054 E017 200.2038418 0.0002419711 1.007984e-11 2.097996e-10 9 92031715 92031842 128 - 2.170 2.395 0.749
ENSG00000090054 E018 500.6094778 0.0042340804 4.953823e-01 6.321949e-01 9 92031843 92032353 511 - 2.612 2.665 0.178
ENSG00000090054 E019 330.9674923 0.0002432090 5.767227e-07 5.042849e-06 9 92032354 92032558 205 - 2.464 2.377 -0.291
ENSG00000090054 E020 32.3397689 0.0006267161 1.240972e-02 3.452304e-02 9 92032559 92033795 1237 - 1.398 1.602 0.700
ENSG00000090054 E021 7.4437666 0.0023900707 2.164170e-02 5.493120e-02 9 92033796 92033839 44 - 0.775 1.088 1.179
ENSG00000090054 E022 16.3178705 0.0012002232 3.015698e-02 7.227625e-02 9 92033840 92034066 227 - 1.114 1.345 0.816
ENSG00000090054 E023 24.6230546 0.0080531863 7.677541e-01 8.499195e-01 9 92034067 92034809 743 - 1.326 1.382 0.194
ENSG00000090054 E024 194.4088961 0.0004004876 1.474369e-04 7.360654e-04 9 92034810 92034883 74 - 2.235 2.147 -0.294
ENSG00000090054 E025 213.9884375 0.0008932650 1.941126e-04 9.386881e-04 9 92038248 92038365 118 - 2.277 2.188 -0.296
ENSG00000090054 E026 0.4460135 0.0344329464 6.143061e-01 7.328189e-01 9 92038366 92038458 93 - 0.170 0.000 -11.790
ENSG00000090054 E027 149.8344836 0.0026704160 1.143946e-02 3.220836e-02 9 92045999 92046053 55 - 2.120 2.043 -0.258
ENSG00000090054 E028 1.1521939 0.0874158959 6.118091e-01 7.308678e-01 9 92046275 92046334 60 - 0.256 0.368 0.733
ENSG00000090054 E029 183.2634061 0.0002774604 4.149950e-04 1.831839e-03 9 92047172 92047268 97 - 2.208 2.127 -0.270
ENSG00000090054 E030 5.6281195 0.0187231005 8.057831e-01 8.765263e-01 9 92047269 92047612 344 - 0.739 0.799 0.240
ENSG00000090054 E031 172.9968153 0.0026068574 1.136663e-04 5.846319e-04 9 92047613 92047708 96 - 2.191 2.059 -0.442
ENSG00000090054 E032 176.2812203 0.0002189683 1.348178e-04 6.804173e-04 9 92049960 92050067 108 - 2.193 2.100 -0.309
ENSG00000090054 E033 2.0889080 0.0953286928 6.281585e-01 7.437716e-01 9 92050296 92050491 196 - 0.465 0.365 -0.541
ENSG00000090054 E034 172.0329267 0.0005798493 1.758246e-05 1.104242e-04 9 92055405 92055494 90 - 2.186 2.067 -0.399
ENSG00000090054 E035 216.1311423 0.0001680083 1.759230e-06 1.385380e-05 9 92059179 92059308 130 - 2.284 2.175 -0.364
ENSG00000090054 E036 235.0184346 0.0002240809 1.177761e-09 1.722029e-08 9 92067966 92068098 133 - 2.327 2.181 -0.486
ENSG00000090054 E037 2.7864524 0.1281566599 1.016457e-01 1.929983e-01 9 92070124 92070296 173 - 0.415 0.755 1.555
ENSG00000090054 E038 1.1468953 0.0115101967 1.927981e-01 3.172806e-01 9 92070344 92070403 60 - 0.215 0.475 1.632
ENSG00000090054 E039 3.8364302 0.0041543577 1.268972e-02 3.518213e-02 9 92076798 92077035 238 - 0.699 0.220 -2.597
ENSG00000090054 E040 23.3407038 0.0014152717 2.068518e-11 4.088749e-10 9 92079061 92079433 373 - 1.135 1.662 1.828
ENSG00000090054 E041 26.3105561 0.0007483780 4.733827e-07 4.206028e-06 9 92079434 92079566 133 - 1.247 1.636 1.345
ENSG00000090054 E042 0.0000000       9 92079853 92080015 163 -      
ENSG00000090054 E043 200.7938853 0.0013200067 4.584059e-04 2.000176e-03 9 92080016 92080084 69 - 2.249 2.159 -0.301
ENSG00000090054 E044 116.3074298 0.0017481343 4.639068e-04 2.021757e-03 9 92080085 92080088 4 - 2.020 1.893 -0.427
ENSG00000090054 E045 206.1874334 0.0002057454 1.638149e-03 6.083833e-03 9 92080870 92080963 94 - 2.255 2.194 -0.202
ENSG00000090054 E046 0.0000000       9 92102805 92102939 135 -      
ENSG00000090054 E047 0.0000000       9 92103190 92103415 226 -      
ENSG00000090054 E048 0.0000000       9 92103936 92103998 63 -      
ENSG00000090054 E049 0.0000000       9 92103999 92104030 32 -      
ENSG00000090054 E050 30.0529475 0.0224880735 7.091629e-14 2.058039e-12 9 92107176 92108069 894 - 1.119 1.846 2.507
ENSG00000090054 E051 1.4006204 0.0095188765 1.162522e-01 2.146198e-01 9 92108070 92108739 670 - 0.255 0.562 1.723
ENSG00000090054 E052 199.3824429 0.0002123507 2.415726e-04 1.139941e-03 9 92108740 92108834 95 - 2.244 2.164 -0.266
ENSG00000090054 E053 156.9995894 0.0020348604 1.709162e-04 8.390226e-04 9 92112455 92112562 108 - 2.149 2.022 -0.425
ENSG00000090054 E054 4.5660190 0.0123908420 1.285657e-01 2.321624e-01 9 92114922 92115066 145 - 0.726 0.475 -1.124
ENSG00000090054 E055 1.1929815 0.0150413613 1.151953e-01 2.131358e-01 9 92115067 92115313 247 - 0.358 0.000 -13.185
ENSG00000090054 E056 95.1113417 0.0003756305 1.004334e-02 2.886917e-02 9 92115314 92115413 100 - 1.926 1.844 -0.276