ENSG00000090020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263980 ENSG00000090020 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC9A1 protein_coding protein_coding 12.99566 16.46491 10.49808 1.230379 0.5519198 -0.6487713 7.0971420 6.393479 7.666920 0.9119807 0.3132761 0.2616717 0.56817500 0.38800000 0.7378000 0.34980000 0.01419995 0.01419995 FALSE TRUE
ENST00000490329 ENSG00000090020 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC9A1 protein_coding processed_transcript 12.99566 16.46491 10.49808 1.230379 0.5519198 -0.6487713 0.4335468 1.040700 0.000000 0.5209463 0.0000000 -6.7152071 0.02655417 0.06273333 0.0000000 -0.06273333 0.19255766 0.01419995   FALSE
MSTRG.633.1 ENSG00000090020 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC9A1 protein_coding   12.99566 16.46491 10.49808 1.230379 0.5519198 -0.6487713 3.9968845 7.550653 1.585829 0.1123122 0.6175725 -2.2442052 0.28849167 0.46256667 0.1465333 -0.31603333 0.01834866 0.01419995 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000090020 E001 0.3299976 0.0277370123 3.756213e-01   1 27098809 27098814 6 - 0.000 0.177 10.469
ENSG00000090020 E002 0.3299976 0.0277370123 3.756213e-01   1 27098815 27098815 1 - 0.000 0.177 12.479
ENSG00000090020 E003 44.1649550 0.0220256128 2.651097e-04 1.237640e-03 1 27098816 27098886 71 - 1.366 1.723 1.223
ENSG00000090020 E004 91.1378390 0.0215225421 3.718679e-05 2.159695e-04 1 27098887 27099004 118 - 1.673 2.030 1.204
ENSG00000090020 E005 205.5933904 0.0103499473 7.556152e-07 6.444381e-06 1 27099005 27099211 207 - 2.087 2.365 0.928
ENSG00000090020 E006 534.9720230 0.0005862438 5.493410e-21 3.957072e-19 1 27099212 27100344 1133 - 2.581 2.751 0.569
ENSG00000090020 E007 211.9592294 0.0018158588 1.636685e-01 2.799103e-01 1 27100345 27100644 300 - 2.266 2.312 0.155
ENSG00000090020 E008 109.1362354 0.0002803386 8.226567e-01 8.881902e-01 1 27101203 27101275 73 - 2.007 2.016 0.030
ENSG00000090020 E009 106.1335532 0.0005237398 8.073105e-01 8.775882e-01 1 27101725 27101826 102 - 1.992 2.002 0.033
ENSG00000090020 E010 107.1678762 0.0003935543 9.267696e-01 9.579065e-01 1 27102016 27102130 115 - 2.005 2.009 0.014
ENSG00000090020 E011 119.6005772 0.0002660842 9.316388e-02 1.800706e-01 1 27102385 27102558 174 - 2.090 2.035 -0.183
ENSG00000090020 E012 89.1545690 0.0018188643 4.779542e-04 2.075671e-03 1 27102673 27102743 71 - 2.019 1.874 -0.487
ENSG00000090020 E013 0.8576959 0.3295440932 5.143156e-01 6.490338e-01 1 27102744 27102795 52 - 0.355 0.181 -1.289
ENSG00000090020 E014 99.0318073 0.0004797119 1.411711e-06 1.134777e-05 1 27103223 27103312 90 - 2.079 1.905 -0.584
ENSG00000090020 E015 5.7979474 0.0030646709 4.440297e-01 5.856029e-01 1 27103313 27104022 710 - 0.862 0.764 -0.387
ENSG00000090020 E016 5.5773585 0.0136924093 6.865810e-01 7.890821e-01 1 27105451 27105884 434 - 0.837 0.781 -0.218
ENSG00000090020 E017 130.3548587 0.0032749097 4.252812e-03 1.384977e-02 1 27105885 27106087 203 - 2.162 2.047 -0.385
ENSG00000090020 E018 116.7538059 0.0009206169 2.216295e-01 3.523493e-01 1 27107648 27107865 218 - 2.070 2.028 -0.142
ENSG00000090020 E019 134.2226201 0.0069425389 1.054597e-02 3.008302e-02 1 27109527 27109777 251 - 2.179 2.059 -0.403
ENSG00000090020 E020 152.6168479 0.0062301868 6.370945e-04 2.670142e-03 1 27113826 27114232 407 - 2.253 2.101 -0.509
ENSG00000090020 E021 52.3197475 0.0089587033 1.528952e-02 4.114540e-02 1 27114233 27114286 54 - 1.799 1.639 -0.544
ENSG00000090020 E022 139.1046618 0.0088865043 1.062441e-05 7.018245e-05 1 27153983 27154361 379 - 2.256 2.029 -0.761
ENSG00000090020 E023 140.7451877 0.0088348032 6.530144e-07 5.644036e-06 1 27154362 27155125 764 - 2.277 2.020 -0.860
ENSG00000090020 E024 0.1451727 0.0428392993 2.999790e-01   1 27155354 27155404 51 - 0.152 0.000 -12.939
ENSG00000090020 E025 0.1451727 0.0428392993 2.999790e-01   1 27155405 27155416 12 - 0.152 0.000 -12.939
ENSG00000090020 E026 0.0000000       1 27166771 27166981 211 -