ENSG00000089902

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262241 ENSG00000089902 HEK293_OSMI2_2hA HEK293_TMG_2hB RCOR1 protein_coding protein_coding 12.70924 9.194255 17.46858 0.5434541 0.4891638 0.9252149 8.979882 8.554599 11.926765 0.2956131 0.6811901 0.4789543 0.7597958 0.9339 0.6846333 -0.2492667 1.648129e-01 1.727538e-16 FALSE TRUE
MSTRG.10204.3 ENSG00000089902 HEK293_OSMI2_2hA HEK293_TMG_2hB RCOR1 protein_coding   12.70924 9.194255 17.46858 0.5434541 0.4891638 0.9252149 2.209370 0.000000 4.050399 0.0000000 0.6814148 8.6654778 0.1295958 0.0000 0.2315000 0.2315000 1.727538e-16 1.727538e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089902 E001 22.4459874 0.0103697180 3.463302e-11 6.598734e-10 14 102592649 102593016 368 + 1.526 0.918 -2.162
ENSG00000089902 E002 14.0479819 0.0371325437 1.707283e-06 1.348396e-05 14 102593017 102593043 27 + 1.336 0.688 -2.416
ENSG00000089902 E003 41.4990345 0.0147931172 1.119630e-05 7.354736e-05 14 102593044 102593187 144 + 1.723 1.414 -1.053
ENSG00000089902 E004 48.9625082 0.0027194429 4.058660e-08 4.457656e-07 14 102593266 102593325 60 + 1.778 1.521 -0.875
ENSG00000089902 E005 63.6140790 0.0004527697 9.501150e-12 1.987374e-10 14 102681895 102681978 84 + 1.890 1.634 -0.866
ENSG00000089902 E006 55.6234093 0.0004579941 1.235368e-10 2.147915e-09 14 102701278 102701330 53 + 1.832 1.573 -0.877
ENSG00000089902 E007 90.3490289 0.0044173461 5.375452e-07 4.725584e-06 14 102707351 102707512 162 + 2.021 1.835 -0.626
ENSG00000089902 E008 101.3384200 0.0060390943 1.434243e-03 5.420817e-03 14 102708465 102708583 119 + 2.040 1.941 -0.332
ENSG00000089902 E009 0.0000000       14 102710742 102710934 193 +      
ENSG00000089902 E010 96.2854572 0.0017771310 6.386447e-05 3.503586e-04 14 102710935 102711013 79 + 2.018 1.919 -0.334
ENSG00000089902 E011 127.1699768 0.0050689084 5.757806e-03 1.797566e-02 14 102714423 102714617 195 + 2.125 2.064 -0.205
ENSG00000089902 E012 0.0000000       14 102720926 102721006 81 +      
ENSG00000089902 E013 53.9920744 0.0008976366 3.030403e-02 7.256586e-02 14 102721007 102721021 15 + 1.753 1.712 -0.137
ENSG00000089902 E014 74.2172959 0.0003697540 6.819186e-04 2.832995e-03 14 102721022 102721084 63 + 1.901 1.826 -0.251
ENSG00000089902 E015 68.2363984 0.0003833068 2.712569e-03 9.410836e-03 14 102721320 102721377 58 + 1.858 1.794 -0.215
ENSG00000089902 E016 1.1060972 0.0115755577 5.242550e-01 6.578476e-01 14 102721378 102721551 174 + 0.349 0.269 -0.527
ENSG00000089902 E017 138.7347307 0.0029201638 9.230605e-04 3.695734e-03 14 102722187 102722416 230 + 2.164 2.099 -0.218
ENSG00000089902 E018 0.7353121 0.1649769982 7.084645e-01 8.061054e-01 14 102724864 102724913 50 + 0.174 0.273 0.828
ENSG00000089902 E019 83.1171800 0.0009404869 2.586340e-04 1.211159e-03 14 102726468 102726561 94 + 1.953 1.868 -0.284
ENSG00000089902 E020 1022.7726820 0.0007092778 1.946102e-13 5.310907e-12 14 102726562 102729875 3314 + 2.936 3.087 0.502
ENSG00000089902 E021 342.2464168 0.0151758366 5.055696e-10 7.905790e-09 14 102729876 102730561 686 + 2.305 2.728 1.407