ENSG00000089775

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394715 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding protein_coding 4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 0.40372502 0.2227675 0.4010607 0.04888088 0.06831342 0.82046176 0.09402083 0.04853333 0.10573333 0.057200000 2.721650e-01 3.19435e-06 FALSE TRUE
ENST00000555220 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding protein_coding 4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 0.21424503 0.1974292 0.1957424 0.01667936 0.01167445 -0.01177999 0.05118750 0.04526667 0.05056667 0.005300000 8.862271e-01 3.19435e-06   FALSE
ENST00000555424 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding protein_coding 4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 0.88808023 1.1267255 0.8109663 0.44398423 0.17605621 -0.46948897 0.19632917 0.22353333 0.21540000 -0.008133333 9.964009e-01 3.19435e-06   FALSE
ENST00000608382 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding protein_coding 4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 0.61412463 0.3511442 0.7146509 0.06987305 0.03767382 1.00471135 0.15299167 0.08283333 0.18256667 0.099733333 1.515313e-01 3.19435e-06 FALSE TRUE
MSTRG.9709.4 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding   4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 0.07611841 0.0000000 0.1789615 0.00000000 0.17896154 4.24002072 0.02220000 0.00000000 0.05726667 0.057266667 8.235358e-01 3.19435e-06   FALSE
MSTRG.9709.5 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding   4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 1.52689326 2.6625366 0.6142552 0.55279840 0.40531112 -2.09800193 0.33709167 0.56253333 0.13483333 -0.427700000 1.197490e-01 3.19435e-06 FALSE FALSE
MSTRG.9709.8 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding   4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 0.16681993 0.0000000 0.6174726 0.00000000 0.20966574 5.97148046 0.03795417 0.00000000 0.14580000 0.145800000 3.194350e-06 3.19435e-06 FALSE FALSE
MSTRG.9709.9 ENSG00000089775 HEK293_OSMI2_2hA HEK293_TMG_2hB ZBTB25 protein_coding   4.353489 4.751053 4.020349 0.8827717 0.4605464 -0.2403759 0.28792624 0.0000000 0.3929471 0.00000000 0.25042528 5.33251846 0.06482083 0.00000000 0.08640000 0.086400000 1.551168e-01 3.19435e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089775 E001 4.3490825 0.003689757 7.725573e-01 8.531893e-01 14 64449106 64449284 179 - 0.733 0.730 -0.013
ENSG00000089775 E002 3.2815802 0.005007392 1.942187e-01 3.190558e-01 14 64449285 64449329 45 - 0.547 0.702 0.678
ENSG00000089775 E003 8.9015848 0.027345503 5.685818e-03 1.778167e-02 14 64449330 64449431 102 - 0.803 1.117 1.174
ENSG00000089775 E004 6.6225323 0.004453963 5.556583e-03 1.743681e-02 14 64449432 64449444 13 - 0.707 1.003 1.147
ENSG00000089775 E005 25.5598684 0.013859426 4.209782e-07 3.780303e-06 14 64449445 64449638 194 - 1.181 1.564 1.330
ENSG00000089775 E006 102.1923559 0.056321371 2.392044e-02 5.963960e-02 14 64478051 64486838 8788 - 2.121 1.889 -0.780
ENSG00000089775 E007 15.1599281 0.001291092 8.987459e-01 9.394226e-01 14 64486839 64487113 275 - 1.240 1.179 -0.215
ENSG00000089775 E008 14.1133790 0.012711481 7.503044e-01 8.370192e-01 14 64487114 64487196 83 - 1.190 1.169 -0.075
ENSG00000089775 E009 28.7304602 0.009747883 5.451508e-01 6.755618e-01 14 64487197 64487764 568 - 1.524 1.428 -0.331
ENSG00000089775 E010 8.2093709 0.010800282 6.339360e-02 1.323474e-01 14 64487765 64487800 36 - 1.091 0.826 -0.991
ENSG00000089775 E011 17.6214381 0.007785016 2.406552e-03 8.481806e-03 14 64487801 64488057 257 - 1.413 1.094 -1.126
ENSG00000089775 E012 36.9467350 0.028969032 1.132391e-02 3.193903e-02 14 64490361 64490540 180 - 1.481 1.648 0.570
ENSG00000089775 E013 1.0371996 0.015361602 7.570880e-03 2.269647e-02 14 64495243 64495431 189 - 0.506 0.000 -11.628
ENSG00000089775 E014 3.4009346 0.004515015 8.415180e-02 1.660536e-01 14 64499441 64499563 123 - 0.781 0.480 -1.322
ENSG00000089775 E015 3.0365809 0.005716075 2.921903e-02 7.042955e-02 14 64502569 64502815 247 - 0.758 0.370 -1.812
ENSG00000089775 E016 4.5070424 0.003632472 5.235722e-01 6.572259e-01 14 64502901 64503127 227 - 0.803 0.672 -0.534
ENSG00000089775 E017 12.5739973 0.005003670 5.314183e-03 1.678794e-02 14 64503661 64503861 201 - 1.006 1.225 0.789
ENSG00000089775 E018 0.8836184 0.019203612 5.121075e-01 6.470360e-01 14 64504487 64505213 727 - 0.212 0.303 0.682