ENSG00000089737

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330836 ENSG00000089737 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX24 protein_coding protein_coding 135.2987 145.0551 140.278 16.3582 0.3674018 -0.04830876 22.74214 22.39696 21.619440 2.299030 1.7361927 -0.05095067 0.17027500 0.1554667 0.15416667 -0.00130000 1.000000e+00 8.758845e-08 FALSE TRUE
ENST00000544005 ENSG00000089737 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX24 protein_coding protein_coding 135.2987 145.0551 140.278 16.3582 0.3674018 -0.04830876 11.32917 24.05047 4.629414 2.110483 1.3203236 -2.37465044 0.08112083 0.1668667 0.03296667 -0.13390000 6.547017e-06 8.758845e-08 FALSE TRUE
ENST00000555054 ENSG00000089737 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX24 protein_coding protein_coding 135.2987 145.0551 140.278 16.3582 0.3674018 -0.04830876 51.86268 52.17209 52.684746 6.069894 0.6863106 0.01410430 0.38487500 0.3594000 0.37556667 0.01616667 6.154508e-01 8.758845e-08 FALSE TRUE
ENST00000555324 ENSG00000089737 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX24 protein_coding retained_intron 135.2987 145.0551 140.278 16.3582 0.3674018 -0.04830876 42.87758 38.25925 56.813504 5.184221 0.2035384 0.57030235 0.31397917 0.2655000 0.40500000 0.13950000 3.639553e-03 8.758845e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089737 E001 62.2717723 6.240585e-04 1.056274e-06 8.722310e-06 14 94048287 94050919 2633 - 1.639 1.871 0.784
ENSG00000089737 E002 2.9655408 1.707725e-01 8.343448e-01 8.962794e-01 14 94050920 94050921 2 - 0.644 0.548 -0.426
ENSG00000089737 E003 5.6954998 8.979976e-02 3.248588e-01 4.682722e-01 14 94050922 94050922 1 - 0.712 0.880 0.665
ENSG00000089737 E004 22.5992477 9.026190e-04 1.042142e-01 1.969108e-01 14 94050923 94050937 15 - 1.297 1.415 0.408
ENSG00000089737 E005 44.7670938 9.188749e-03 2.410126e-04 1.137610e-03 14 94050938 94050964 27 - 1.472 1.744 0.927
ENSG00000089737 E006 620.5086207 7.936906e-03 9.213019e-05 4.850161e-04 14 94050965 94051187 223 - 2.669 2.840 0.568
ENSG00000089737 E007 636.4342241 3.884573e-03 1.670328e-07 1.625847e-06 14 94051188 94051259 72 - 2.684 2.850 0.552
ENSG00000089737 E008 1105.9802035 1.538796e-03 6.657049e-12 1.427134e-10 14 94051260 94051462 203 - 2.945 3.082 0.455
ENSG00000089737 E009 0.3686942 3.933147e-02 8.443540e-01 9.031337e-01 14 94051748 94051824 77 - 0.139 0.108 -0.418
ENSG00000089737 E010 962.3037302 1.790956e-04 1.756739e-22 1.480466e-20 14 94052998 94053127 130 - 2.898 3.020 0.405
ENSG00000089737 E011 3.8298007 4.234692e-03 2.251428e-01 3.566006e-01 14 94053128 94053378 251 - 0.561 0.740 0.770
ENSG00000089737 E012 1164.7826953 1.057372e-04 4.623555e-20 2.956189e-18 14 94054996 94055184 189 - 2.997 3.095 0.328
ENSG00000089737 E013 75.3396653 3.303716e-04 4.041663e-12 8.968969e-11 14 94055185 94056015 831 - 2.027 1.742 -0.959
ENSG00000089737 E014 114.9872559 4.056312e-04 4.258201e-46 2.089905e-43 14 94056016 94057821 1806 - 2.290 1.796 -1.656
ENSG00000089737 E015 669.1863451 3.708473e-04 1.006093e-09 1.491520e-08 14 94057822 94057897 76 - 2.758 2.854 0.320
ENSG00000089737 E016 1756.7569756 6.952553e-05 7.184072e-04 2.964885e-03 14 94060098 94060613 516 - 3.222 3.247 0.084
ENSG00000089737 E017 658.9162208 2.405190e-04 2.843365e-01 4.245651e-01 14 94060913 94061066 154 - 2.804 2.815 0.037
ENSG00000089737 E018 1752.4116963 3.388553e-04 1.437144e-12 3.429433e-11 14 94062097 94062621 525 - 3.286 3.199 -0.290
ENSG00000089737 E019 2.8755256 1.323159e-02 1.381668e-01 2.455330e-01 14 94078966 94079024 59 - 0.711 0.472 -1.074
ENSG00000089737 E020 575.0528371 1.288453e-03 5.697805e-07 4.986981e-06 14 94079025 94079069 45 - 2.821 2.700 -0.404
ENSG00000089737 E021 824.3419763 7.862749e-04 3.465201e-07 3.165093e-06 14 94079070 94079234 165 - 2.965 2.867 -0.326
ENSG00000089737 E022 1418.5341155 8.131718e-04 2.868775e-13 7.644970e-12 14 94079235 94079621 387 - 3.213 3.091 -0.406
ENSG00000089737 E023 735.1547701 2.401850e-03 3.119690e-11 5.989217e-10 14 94079622 94079747 126 - 2.962 2.774 -0.626
ENSG00000089737 E024 401.4226330 7.290656e-03 7.075309e-07 6.068710e-06 14 94081119 94081202 84 - 2.724 2.485 -0.795