ENSG00000089639

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000203556 ENSG00000089639 HEK293_OSMI2_2hA HEK293_TMG_2hB GMIP protein_coding protein_coding 3.328263 4.917681 1.815162 0.5317959 0.2628605 -1.432885 2.0221270 3.0293110 1.17522934 0.13804628 0.09799127 -1.3585781 0.61272917 0.62610000 0.68123333 0.05513333 0.83743990 0.01264368 FALSE TRUE
ENST00000586269 ENSG00000089639 HEK293_OSMI2_2hA HEK293_TMG_2hB GMIP protein_coding processed_transcript 3.328263 4.917681 1.815162 0.5317959 0.2628605 -1.432885 0.2068670 0.5268031 0.00000000 0.31568046 0.00000000 -5.7463211 0.05981250 0.09996667 0.00000000 -0.09996667 0.01264368 0.01264368 FALSE FALSE
ENST00000587238 ENSG00000089639 HEK293_OSMI2_2hA HEK293_TMG_2hB GMIP protein_coding protein_coding 3.328263 4.917681 1.815162 0.5317959 0.2628605 -1.432885 0.3239999 0.5740793 0.09972758 0.09564230 0.06590603 -2.4122381 0.08450833 0.11523333 0.04733333 -0.06790000 0.26998713 0.01264368 FALSE TRUE
ENST00000588171 ENSG00000089639 HEK293_OSMI2_2hA HEK293_TMG_2hB GMIP protein_coding nonsense_mediated_decay 3.328263 4.917681 1.815162 0.5317959 0.2628605 -1.432885 0.2535576 0.3328899 0.25292246 0.16902983 0.25292246 -0.3831082 0.08643333 0.06153333 0.10836667 0.04683333 0.85173617 0.01264368 FALSE FALSE
ENST00000591047 ENSG00000089639 HEK293_OSMI2_2hA HEK293_TMG_2hB GMIP protein_coding nonsense_mediated_decay 3.328263 4.917681 1.815162 0.5317959 0.2628605 -1.432885 0.2474444 0.1469407 0.08552123 0.08656311 0.08552123 -0.7163264 0.07026667 0.03473333 0.05776667 0.02303333 0.91769763 0.01264368 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089639 E001 46.6916528 0.0022406775 0.114610256 0.21226690 19 19629476 19629842 367 - 1.522 1.622 0.342
ENSG00000089639 E002 64.5991624 0.0004660548 0.011033400 0.03124291 19 19629843 19630336 494 - 1.625 1.758 0.450
ENSG00000089639 E003 22.6956530 0.0139268123 0.414933387 0.55834163 19 19630471 19630537 67 - 1.233 1.320 0.302
ENSG00000089639 E004 33.1033430 0.0011454200 0.131796624 0.23661867 19 19633803 19634110 308 - 1.366 1.476 0.380
ENSG00000089639 E005 15.9744910 0.0050949940 0.873981823 0.92300674 19 19634111 19634190 80 - 1.140 1.156 0.060
ENSG00000089639 E006 23.9188837 0.0062086763 0.456278273 0.59672610 19 19634507 19634703 197 - 1.261 1.327 0.231
ENSG00000089639 E007 25.5096874 0.0008956403 0.532835305 0.66514707 19 19634792 19634929 138 - 1.299 1.349 0.175
ENSG00000089639 E008 21.9206741 0.0009167568 0.660834118 0.76943732 19 19635025 19635091 67 - 1.248 1.285 0.133
ENSG00000089639 E009 12.8549328 0.0014185160 0.763780888 0.84702340 19 19635092 19635094 3 - 1.084 1.053 -0.112
ENSG00000089639 E010 28.2060944 0.0009077467 0.847494431 0.90530668 19 19635095 19635213 119 - 1.366 1.381 0.052
ENSG00000089639 E011 30.5395347 0.0009238112 0.675882544 0.78101277 19 19635415 19635569 155 - 1.387 1.418 0.107
ENSG00000089639 E012 1.9209292 0.0103960190 0.160889598 0.27627762 19 19635570 19635643 74 - 0.578 0.331 -1.280
ENSG00000089639 E013 13.0023269 0.0014254931 0.019147197 0.04965883 19 19635644 19635721 78 - 1.234 1.006 -0.819
ENSG00000089639 E014 21.3803296 0.0008734728 0.358053268 0.50244847 19 19636707 19636787 81 - 1.205 1.285 0.284
ENSG00000089639 E015 10.4224270 0.0017030132 0.536926233 0.66858856 19 19636788 19636796 9 - 0.915 0.990 0.278
ENSG00000089639 E016 17.2320618 0.0010652784 0.910079688 0.94684453 19 19636917 19637029 113 - 1.173 1.184 0.039
ENSG00000089639 E017 13.2571292 0.0253137083 0.852499962 0.90859950 19 19637365 19637561 197 - 1.064 1.082 0.066
ENSG00000089639 E018 8.8205803 0.0319190922 0.355713119 0.50006147 19 19637920 19638057 138 - 1.020 0.885 -0.505
ENSG00000089639 E019 4.1748878 0.0822258279 0.832458845 0.89501781 19 19638159 19638167 9 - 0.691 0.630 -0.258
ENSG00000089639 E020 5.9024594 0.0042873938 0.109243939 0.20443864 19 19638168 19638195 28 - 0.915 0.699 -0.852
ENSG00000089639 E021 7.3310761 0.0023870826 0.431343776 0.57389815 19 19638196 19638205 10 - 0.915 0.815 -0.387
ENSG00000089639 E022 16.5092624 0.0015910544 0.156523396 0.27047657 19 19638206 19638329 124 - 1.261 1.133 -0.455
ENSG00000089639 E023 24.4240532 0.0012905600 0.003352732 0.01130006 19 19638402 19638482 81 - 1.484 1.268 -0.750
ENSG00000089639 E024 29.3036044 0.0007214382 0.054146242 0.11650682 19 19640085 19640192 108 - 1.499 1.367 -0.457
ENSG00000089639 E025 17.3697339 0.0011054608 0.774046307 0.85429593 19 19640296 19640327 32 - 1.205 1.179 -0.091
ENSG00000089639 E026 16.9144339 0.0014061264 0.606573932 0.72667585 19 19640328 19640360 33 - 1.140 1.189 0.178
ENSG00000089639 E027 23.9783233 0.0056810420 0.458381166 0.59871167 19 19640446 19640571 126 - 1.366 1.306 -0.211
ENSG00000089639 E028 12.5990730 0.0013915300 0.281063581 0.42092914 19 19641810 19641867 58 - 1.140 1.030 -0.397
ENSG00000089639 E029 16.4947380 0.0011175203 0.297327878 0.43864962 19 19641976 19642051 76 - 1.234 1.139 -0.337
ENSG00000089639 E030 7.4049565 0.0024170074 0.737250359 0.82747738 19 19642535 19642536 2 - 0.817 0.862 0.176
ENSG00000089639 E031 13.9023098 0.0013620070 0.718572125 0.81362787 19 19642537 19642619 83 - 1.063 1.101 0.137
ENSG00000089639 E032 0.4428904 0.4495227901 0.838272560 0.89888224 19 19643100 19643227 128 - 0.000 0.146 8.503
ENSG00000089639 E033 8.0609879 0.0022107987 0.928109225 0.95873258 19 19643511 19643657 147 - 0.885 0.874 -0.042