ENSG00000089486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000562334 ENSG00000089486 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIP1 protein_coding protein_coding 43.17273 79.141 29.28473 2.299914 0.3622682 -1.433966 5.419804 5.426255 6.447295 2.0726656 1.1723009 0.2483168 0.16003750 0.06743333 0.2194000 0.15196667 0.01570382 0.01520736 FALSE TRUE
ENST00000563332 ENSG00000089486 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIP1 protein_coding protein_coding 43.17273 79.141 29.28473 2.299914 0.3622682 -1.433966 4.247722 7.487784 4.242200 0.5869391 0.2901141 -0.8182548 0.09557083 0.09450000 0.1449000 0.05040000 0.01520736 0.01520736 FALSE TRUE
ENST00000564828 ENSG00000089486 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIP1 protein_coding protein_coding 43.17273 79.141 29.28473 2.299914 0.3622682 -1.433966 10.379483 24.135020 6.302932 1.4901816 0.5438981 -1.9353435 0.20988333 0.30580000 0.2157667 -0.09003333 0.11962328 0.01520736   FALSE
ENST00000567695 ENSG00000089486 HEK293_OSMI2_2hA HEK293_TMG_2hB CDIP1 protein_coding protein_coding 43.17273 79.141 29.28473 2.299914 0.3622682 -1.433966 22.714784 41.361747 12.083055 2.0004300 1.0901278 -1.7744671 0.52438333 0.52300000 0.4128667 -0.11013333 0.20131353 0.01520736 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089486 E001 0.0000000       16 4510669 4510674 6 -      
ENSG00000089486 E002 4.7864945 0.0035299423 4.555883e-01 0.5961036132 16 4510675 4510738 64 - 0.590 0.717 0.545
ENSG00000089486 E003 588.4594748 0.0011465994 4.806074e-02 0.1057351823 16 4510739 4511420 682 - 2.632 2.689 0.187
ENSG00000089486 E004 1084.7734283 0.0004643561 6.608136e-06 0.0000457730 16 4511421 4511805 385 - 2.881 2.960 0.263
ENSG00000089486 E005 630.1219774 0.0022237802 2.696844e-02 0.0659305598 16 4511806 4511932 127 - 2.653 2.724 0.238
ENSG00000089486 E006 1274.8165317 0.0006892272 4.259669e-02 0.0958125944 16 4511933 4512398 466 - 2.982 3.023 0.138
ENSG00000089486 E007 404.7069259 0.0004972078 1.094845e-02 0.0310376494 16 4512399 4512453 55 - 2.552 2.504 -0.162
ENSG00000089486 E008 616.2855711 0.0002242336 1.088054e-02 0.0308820822 16 4512454 4512611 158 - 2.725 2.690 -0.118
ENSG00000089486 E009 374.5746765 0.0002004113 9.053434e-03 0.0264108337 16 4512612 4512683 72 - 2.519 2.470 -0.161
ENSG00000089486 E010 197.9063421 0.0002183610 5.592308e-04 0.0023819552 16 4512791 4512797 7 - 2.277 2.185 -0.308
ENSG00000089486 E011 311.9894481 0.0001868914 3.236747e-05 0.0001909899 16 4512798 4512866 69 - 2.471 2.382 -0.296
ENSG00000089486 E012 227.9664288 0.0004589802 5.252828e-03 0.0166196105 16 4512867 4512915 49 - 2.321 2.250 -0.238
ENSG00000089486 E013 143.3940506 0.0035426564 2.993182e-01 0.4408307318 16 4512916 4512947 32 - 2.094 2.057 -0.124
ENSG00000089486 E014 143.4105840 0.0138369677 8.588487e-01 0.9129340703 16 4512948 4512998 51 - 2.074 2.066 -0.025
ENSG00000089486 E015 94.1085231 0.0021532414 8.700279e-01 0.9203889392 16 4512999 4513013 15 - 1.885 1.885 0.001
ENSG00000089486 E016 98.7623668 0.0076724664 8.545477e-01 0.9100242370 16 4513014 4513064 51 - 1.910 1.906 -0.013
ENSG00000089486 E017 0.2214452 0.0389075037 1.000000e+00   16 4513694 4513695 2 - 0.000 0.073 8.415
ENSG00000089486 E018 124.9275817 0.0002839418 7.322433e-01 0.8237362087 16 4513696 4513815 120 - 2.009 2.004 -0.016
ENSG00000089486 E019 90.0324204 0.0003403501 9.784704e-01 0.9906499041 16 4513816 4513851 36 - 1.858 1.867 0.032
ENSG00000089486 E020 2.7143525 0.0059779006 7.987484e-02 0.1593652395 16 4514045 4514045 1 - 0.198 0.553 2.153
ENSG00000089486 E021 190.4652369 0.0008569418 2.172429e-01 0.3470621969 16 4514046 4514144 99 - 2.150 2.201 0.169
ENSG00000089486 E022 2.0156633 0.0274567249 4.708101e-01 0.6100165062 16 4514145 4514149 5 - 0.520 0.392 -0.655
ENSG00000089486 E023 216.7346749 0.0012781746 2.971946e-01 0.4385007609 16 4514575 4514630 56 - 2.266 2.241 -0.084
ENSG00000089486 E024 211.6393391 0.0012559858 1.887475e-01 0.3121671405 16 4514631 4514664 34 - 2.264 2.230 -0.114
ENSG00000089486 E025 2.0218912 0.0069794336 5.538733e-01 0.6829440966 16 4514665 4515109 445 - 0.333 0.452 0.665
ENSG00000089486 E026 0.2214452 0.0389075037 1.000000e+00   16 4522417 4522525 109 - 0.000 0.073 8.415
ENSG00000089486 E027 4.5286934 0.0037478336 4.206221e-01 0.5638162545 16 4523827 4524302 476 - 0.750 0.634 -0.484
ENSG00000089486 E028 3.1011194 0.0598195241 6.513069e-01 0.7621919578 16 4536440 4536768 329 - 0.590 0.511 -0.368
ENSG00000089486 E029 62.5326657 0.0004135819 3.175948e-04 0.0014511451 16 4538325 4538701 377 - 1.840 1.669 -0.578
ENSG00000089486 E030 152.9383718 0.0032511972 5.196477e-01 0.6537159942 16 4538702 4538828 127 - 2.067 2.104 0.125