ENSG00000089234

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327551 ENSG00000089234 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAP protein_coding protein_coding 11.56434 10.31409 14.63436 0.2301461 0.4411122 0.5043303 2.3378901 2.3687769 2.0463403 0.54953258 0.2459647 -0.2101409 0.19749167 0.22900000 0.1411000 -0.08790000 0.36865592 0.01029245 FALSE TRUE
ENST00000419234 ENSG00000089234 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAP protein_coding protein_coding 11.56434 10.31409 14.63436 0.2301461 0.4411122 0.5043303 6.8611100 6.3751052 8.8534769 0.23078012 0.2263135 0.4731623 0.60427500 0.61860000 0.6069333 -0.01166667 0.95902769 0.01029245 FALSE TRUE
MSTRG.8030.3 ENSG00000089234 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAP protein_coding   11.56434 10.31409 14.63436 0.2301461 0.4411122 0.5043303 1.1266342 0.9509501 1.8718146 0.42035985 0.3378274 0.9695910 0.08967917 0.09156667 0.1269667 0.03540000 0.66345060 0.01029245 FALSE TRUE
MSTRG.8030.4 ENSG00000089234 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAP protein_coding   11.56434 10.31409 14.63436 0.2301461 0.4411122 0.5043303 0.7690408 0.4519540 0.6809911 0.25482698 0.5430917 0.5809177 0.06282083 0.04480000 0.0452000 0.00040000 0.95817905 0.01029245 FALSE TRUE
MSTRG.8030.5 ENSG00000089234 HEK293_OSMI2_2hA HEK293_TMG_2hB BRAP protein_coding   11.56434 10.31409 14.63436 0.2301461 0.4411122 0.5043303 0.4570589 0.1217595 1.1817369 0.07664945 0.2715977 3.1770868 0.04461250 0.01156667 0.0798000 0.06823333 0.01029245 0.01029245 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000089234 E001 348.5794400 0.0002876125 5.203798e-01 6.543478e-01 12 111642146 111644081 1936 - 2.538 2.549 0.035
ENSG00000089234 E002 141.5020704 0.0004150254 1.722811e-02 4.545131e-02 12 111644082 111644338 257 - 2.118 2.188 0.234
ENSG00000089234 E003 198.6202493 0.0039213339 6.063039e-04 2.556305e-03 12 111644339 111644562 224 - 2.234 2.360 0.419
ENSG00000089234 E004 139.6584235 0.0005289638 5.145123e-06 3.651214e-05 12 111649939 111650042 104 - 2.076 2.213 0.461
ENSG00000089234 E005 109.3016360 0.0002586655 1.012571e-02 2.907243e-02 12 111655566 111655655 90 - 1.999 2.084 0.283
ENSG00000089234 E006 99.9301307 0.0011184937 5.902295e-01 7.131219e-01 12 111658736 111658845 110 - 1.993 2.011 0.063
ENSG00000089234 E007 107.6115467 0.0047082580 3.936635e-01 5.375482e-01 12 111659207 111659345 139 - 2.054 2.012 -0.141
ENSG00000089234 E008 94.0320537 0.0003273187 9.510407e-03 2.756311e-02 12 111660600 111660675 76 - 2.023 1.929 -0.316
ENSG00000089234 E009 113.2431092 0.0003303400 9.655543e-02 1.851956e-01 12 111665639 111665787 149 - 2.085 2.030 -0.185
ENSG00000089234 E010 89.3069022 0.0003441290 3.439305e-01 4.879841e-01 12 111672661 111672774 114 - 1.974 1.938 -0.120
ENSG00000089234 E011 0.3697384 0.0247886751 1.588889e-01 2.736730e-01 12 111672775 111673311 537 - 0.000 0.232 9.993
ENSG00000089234 E012 95.6423761 0.0003410847 7.798252e-02 1.562314e-01 12 111679151 111679340 190 - 2.017 1.954 -0.213
ENSG00000089234 E013 91.3455211 0.0035145671 9.329017e-03 2.710583e-02 12 111681637 111681835 199 - 2.025 1.907 -0.396
ENSG00000089234 E014 84.2325317 0.0056878427 9.758738e-04 3.877359e-03 12 111683146 111683307 162 - 2.012 1.841 -0.575
ENSG00000089234 E015 2.8023736 0.0066583719 5.508486e-01 6.804062e-01 12 111685588 111685710 123 - 0.634 0.540 -0.421
ENSG00000089234 E016 53.7176355 0.0111636492 9.740418e-06 6.494995e-05 12 111685711 111685957 247 - 1.869 1.556 -1.061